SP600125 suppresses Keap1 expression and results in NRF2-mediated prevention of diabetic nephropathy

Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

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C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21

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Synergistic effects of c-Jun and SP1 in the promotion of TGFβ1-mediated diabetic nephropathy progression

(2016) Pan Gao et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC

(2016) Wenpeng Dong et al.   JOURNAL OF ENDOCRINOLOGY

Specific MAPK inhibitors prevent hyperglycemia-induced renal diseases in type 1 diabetic mouse model

(2016) Zhe Hong et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

(2015) Yangwei Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2

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Metallothionein deletion exacerbates intermittent hypoxia-induced renal injury in mice

(2015) Hao Wu et al.   TOXICOLOGY LETTERS

Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate Restores Nrf2 Activity and Ameliorates Crescentic Glomerulonephritis

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Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways

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Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose-Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

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Hydrogen Sulfide Alleviates Diabetic Nephropathy in a Streptozotocin-induced Diabetic Rat Model

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Inhibition of JNK by compound C66 prevents pathological changes of the aorta in STZ-induced diabetes

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Andrographolide suppresses high glucose-induced fibronectin expression in mesangial cells via inhibiting the AP-1 pathway

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Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

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Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

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Targeting JNK by a New Curcumin Analog to Inhibit NF-kB-Mediated Expression of Cell Adhesion Molecules Attenuates Renal Macrophage Infiltration and Injury in Diabetic Mice

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Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells

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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

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Inhibition of Phosphorylation of JNK Suppresses Aβ-Induced ER Stress and Upregulates Prosurvival Mitochondrial Proteins in Rat Hippocampus

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Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention of Diabetic Nephropathy by Sulforaphane: Possible Role of Nrf2 Upregulation and Activation

(2012) Wenpeng Cui et al.   Oxidative Medicine and Cellular Longevity

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

(2011) Hongting Zheng et al.   DIABETES

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

(2010) T. Jiang et al.   DIABETES

Inactivation of GSK-3  by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

(2009) Y. Wang et al.   DIABETES

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(2008) Suma Dronavalli et al.   Nature clinical practice. Endocrinology & metabolism