Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

(2021) Guoyi Tang et al.   Acta Pharmaceutica Sinica B

Chronic kidney disease

(2021) Kamyar Kalantar-Zadeh et al.   LANCET

Hydralazine attenuates renal inflammation in diabetic rats with ischemia/reperfusion acute kidney injury

(2021) Jyh-Gang Leu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MicroRNA‑199a‑3p suppresses high glucose‑induced apoptosis and inflammation by regulating the IKKβ/NF‑κB signaling pathway in renal tubular epithelial cells

(2020) Ruimin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Thrombomodulin ameliorates transforming growth factor-β1–mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway

(2020) Atsuro Takeshita et al.   KIDNEY INTERNATIONAL

Nrf-2 mediated heme oxygenase-1 activation contributes to the anti-inflammatory and renal protective effects of Ginkgo biloba extract in diabetic nephropathy

(2020) Ting-Ting Chang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway

(2019) Xingfang Guo et al.   Frontiers in Neurology

The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

(2019) Javad Habibi et al.   Cardiovascular Diabetology

Hydralazine improves ischemia-induced neovasculogenesis via xanthine-oxidase inhibition in chronic renal insufficiency

(2019) Ting-Ting Chang et al.   PHARMACOLOGICAL RESEARCH

Drug-induced lupus: Traditional and new concepts

(2018) Augusto Vaglio et al.   AUTOIMMUNITY REVIEWS

Drug repurposing in kidney disease

(2018) Usha Panchapakesan et al.   KIDNEY INTERNATIONAL

Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression

(2017) Björn Tampe et al.   KIDNEY INTERNATIONAL

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

(2017) Esmaeil Dehghan et al.   Nature Communications

Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure

(2016) Tomohiro Tanno et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy

(2016) W. Scheele et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diabetic kidney disease: a clinical update from Kidney Disease: Improving Global Outcomes

(2015) Mark E. Molitch et al.   KIDNEY INTERNATIONAL

Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease

(2015) Björn Tampe et al.   EBioMedicine

Allopurinol treatment improves renal function in patients with type 2 diabetes and asymptomatic hyperuricemia: 3-year randomized parallel-controlled study

(2014) Peng Liu et al.   CLINICAL ENDOCRINOLOGY

Protective effects of aliskiren and valsartan in mice with diabetic nephropathy

(2014) Weidong Wang et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation

(2014) Szu-Yuan Li et al.   KIDNEY INTERNATIONAL

Involvement of Apoptosis Inhibitor of Macrophages in a Rat Hypertension Model with Nephrosclerosis: Possible Mechanisms of Action of Olmesartan and Azelnidipine

(2013) Tadashi Uramatsu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inflammation and Mechanical Stretch Promote Aortic Stiffening in Hypertension Through Activation of p38 Mitogen-Activated Protein Kinase

(2013) Jing Wu et al.   CIRCULATION RESEARCH

Superoxide dismutase mimetic, tempol, aggravates renal injury in advanced-stage stroke-prone spontaneously hypertensive rats

(2013) Ikuko Sugama et al.   JOURNAL OF HYPERTENSION

Proteome wide reduction in AGE modification in streptozotocin induced diabetic mice by hydralazine mediated transglycation

(2013) Suresh K. Kesavan et al.   Scientific Reports

Direct renin inhibition – a promising strategy for renal protection?

(2013) Bolesław Rutkowski   MEDICAL SCIENCE MONITOR

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

Acute renal and hepatic failure associated with allopurinol treatment

(2011) R.M. Fagugli et al.   CLINICAL NEPHROLOGY

Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk

(2010) M. Goicoechea et al.   Clinical Journal of the American Society of Nephrology

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

(2010) X. X. Wang et al.   DIABETES

Ca2+ channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats

(2010) Takao Nishizawa et al.   JOURNAL OF HYPERTENSION

Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats

(2009) Jin Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY