The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder

PROTAC targeted protein degraders: the past is prologue

(2022) Miklós Békés et al.   NATURE REVIEWS DRUG DISCOVERY

Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state

(2022) Ilana M. Nodelman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

(2022) Yong Wei et al.   NUCLEIC ACIDS RESEARCH

Comparative Analysis of Structural Features in SLiMs from Eukaryotes, Bacteria, and Viruses with Importance for Host-Pathogen Interactions

(2022) Heidy Elkhaligy et al.   Pathogens

TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells

(2022) Ziling Liu et al.   Communications Biology

Structure of a backtracked hexasomal intermediate of nucleosome transcription

(2022) Lucas Farnung et al.   MOLECULAR CELL

Structural basis of nucleosome retention during transcription elongation

(2022) Martin Filipovski et al.   SCIENCE

Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT

(2022) Haruhiko Ehara et al.   SCIENCE

InterPro in 2022

(2022) Typhaine Paysan-Lafosse et al.   NUCLEIC ACIDS RESEARCH

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein

(2021) Mariano Genera et al.   Scientific Reports

Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

(2021) Siska Van Belle et al.   Cells

Characterization of functional disordered regions within chromatin associated proteins

(2021) Catherine A. Musselman et al.   iScience

Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22

(2021) Bradley Benjamin et al.   PLoS Genetics

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

(2021) Jasmine Cubuk et al.   Nature Communications

Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes

(2021) Yanfeng He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A ubiquitous disordered protein interaction module orchestrates transcription elongation

(2021) Katerina Cermakova et al.   SCIENCE

Molecular mechanism of SHP2 activation by PD-1 stimulation

(2020) M. Marasco et al.   Science Advances

Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer

(2020) Andreas Marx et al.   DISEASE MARKERS

Cryo-EM structure of SWI/SNF complex bound to a nucleosome

(2020) Yan Han et al.   NATURE

HRP2–DPF3a–BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription

(2020) Xu Zhu et al.   NUCLEIC ACIDS RESEARCH

A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

(2020) Nazar Mashtalir et al.   CELL

The conserved elongation factor Spn1 is required for normal transcription, histone modifications, and splicing in Saccharomyces cerevisiae

(2020) Natalia I Reim et al.   NUCLEIC ACIDS RESEARCH

Molecular Mechanism of LEDGF/p75 Dimerization

(2020) Vanda Lux et al.   STRUCTURE

WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin

(2020) Helga B. Landsverk et al.   Cell Reports

Structural insight into nucleosome transcription by RNA polymerase II with elongation factors

(2019) Haruhiko Ehara et al.   SCIENCE

Resources to Discover and Use Short Linear Motifs in Viral Proteins

(2019) Peter Hraber et al.   TRENDS IN BIOTECHNOLOGY

Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP 4 as YAP inhibitor

(2019) Rebecca E Vargas et al.   EMBO JOURNAL

ELM—the eukaryotic linear motif resource in 2020

(2019) Manjeet Kumar et al.   NUCLEIC ACIDS RESEARCH

Structure of the RSC complex bound to the nucleosome

(2019) Youpi Ye et al.   SCIENCE

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

(2019) Gary LeRoy et al.   Science Advances

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism

(2019) Michael A. Cortazar et al.   MOLECULAR CELL

Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding

(2019) Haibo Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement

(2019) Avinash B Patel et al.   eLife

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation

(2018) Subhalakshmi Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation

(2018) Katerina Cermakova et al.   MOLECULES

A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II

(2018) Pabitra K. Parua et al.   NATURE

Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

(2018) Seychelle M. Vos et al.   NATURE

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

(2018) Dharmendra Dingar et al.   Nature Communications

Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination

(2018) Tea Kecman et al.   Cell Reports

Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7

(2017) Zoé Lens et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the MeCP2–TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders

(2017) Valdeko Kruusvee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the DNA-PK holoenzyme

(2017) Humayun Sharif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex

(2017) Youwei Xu et al.   Nature Communications

Repo-Man/PP1 regulates heterochromatin formation in interphase

(2017) Inês J. de Castro et al.   Nature Communications

Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners

(2017) Jakub Gemperle et al.   Scientific Reports

Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex

(2017) Hung Yi Kristal Kaan et al.   Scientific Reports

The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease

(2016) M. Madan Babu   BIOCHEMICAL SOCIETY TRANSACTIONS

JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma

(2016) T. S. Y. Chan et al.   CANCER RESEARCH

HEAT repeats – versatile arrays of amphiphilic helices working in crowded environments?

(2016) Shige H. Yoshimura et al.   JOURNAL OF CELL SCIENCE

Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia

(2016) Katerina Cermakova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

(2016) Neil Justin et al.   Nature Communications

HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma

(2015) Kun Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses

(2015) Juston C. Weems et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

(2015) Petr Tesina et al.   Nature Communications

Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia

(2014) K.  ermakova et al.   CANCER RESEARCH

Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex

(2014) Kuang-Lei Tsai et al.   CELL

A Million Peptide Motifs for the Molecular Biologist

(2014) Peter Tompa et al.   MOLECULAR CELL

A PP1–PP2A phosphatase relay controls mitotic progression

(2014) Agnes Grallert et al.   NATURE

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75)

(2013) H Méreau et al.   LEUKEMIA

Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain

(2013) Rick van Nuland et al.   Epigenetics & Chromatin

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

(2012) Rik Schrijvers et al.   Retrovirology

Transcriptional Elongation Factor Elongin A Regulates Retinoic Acid-Induced Gene Expression during Neuronal Differentiation

(2012) Takashi Yasukawa et al.   Cell Reports

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

(2011) Hidehisa Takahashi et al.   CELL

The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26

(2010) Marie-Laure Diebold et al.   EMBO JOURNAL

Identification and Characterization of a Novel Human PP1 Phosphatase Complex

(2010) Jeong-Heon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Biological Importance of the Spn1-Spt6 Interaction, and Its Regulatory Role in Nucleosome Binding

(2010) Seth M. McDonald et al.   MOLECULAR CELL

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation

(2009) Judy Qiju Wu et al.   NATURE CELL BIOLOGY

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1

(2008) Takashi Yasukawa et al.   EMBO JOURNAL

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

(2008) S. M. Yoh et al.   GENES & DEVELOPMENT