Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

HRP2–DPF3a–BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription

(2020) Xu Zhu et al.   NUCLEIC ACIDS RESEARCH

Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein–Protein Interaction

(2019) Angelo Aguilar et al.   JOURNAL OF MEDICINAL CHEMISTRY

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

(2019) Gary LeRoy et al.   Science Advances

How to effectively treat acute leukemia patients bearing MLL -rearrangements ?

(2018) Dieter Steinhilber et al.   BIOCHEMICAL PHARMACOLOGY

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation

(2018) Subhalakshmi Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of key genes and signaling pathways involved in Helicobacter pylori -associated gastric cancer based on The Cancer Genome Atlas database and RNA sequencing data

(2018) Yi Hu et al.   HELICOBACTER

QuantSeq 3′ mRNA sequencing for RNA quantification

(2018) Pamela Moll et al.   NATURE METHODS

iTRAQ-based quantitative proteomic analysis reveals the distinct early embryo myofiber type characteristics involved in landrace and miniature pig

(2016) Xumeng Zhang et al.   BMC GENOMICS

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

(2016) Dmitry Borkin et al.   JOURNAL OF MEDICINAL CHEMISTRY

The molecular mechanics of mixed lineage leukemia

(2016) R K Slany   ONCOGENE

HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma

(2015) Kun Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

(2015) Dmitry Borkin et al.   CANCER CELL

Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination

(2015) Annika Baude et al.   NUCLEIC ACIDS RESEARCH

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

(2015) Petr Tesina et al.   Nature Communications

Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice

(2015) Hao Wang et al.   PLoS One

Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia

(2014) K.  ermakova et al.   CANCER RESEARCH

Infants with acute myeloid leukemia treated according to the Associazione Italiana di Ematologia e Oncologia Pediatrica 2002/01 protocol have an outcome comparable to that of older children

(2014) R. Masetti et al.   HAEMATOLOGICA

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75)

(2013) H Méreau et al.   LEUKEMIA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

NMR Analyses of the Interaction between the FYVE Domain of Early Endosome Antigen 1 (EEA1) and Phosphoinositide Embedded in a Lipid Bilayer

(2012) Mariko Yokogawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

(2012) Jing Huang et al.   NATURE

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

(2012) Jolanta Grembecka et al.   Nature Chemical Biology

LEDGF (p75) promotes DNA-end resection and homologous recombination

(2012) Mads Daugaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression of the Stress Response Oncoprotein LEDGF/p75 in Human Cancer: A Study of 21 Tumor Types

(2012) Anamika Basu et al.   PLoS One

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

(2012) Rik Schrijvers et al.   PLoS Pathogens

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia

(2011) B. V. Balgobind et al.   HAEMATOLOGICA

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

(2011) Hong Wu et al.   PLoS One

Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells

(2011) Anamika Basu et al.   PROSTATE

Gonadotropin-Regulated Lymphangiogenesis in Ovarian Cancer Is Mediated by LEDGF-Induced Expression of VEGF-C

(2009) S. Sapoznik et al.   CANCER RESEARCH

Transcriptional Co-activator LEDGF Interacts with Cdc7-Activator of S-phase Kinase (ASK) and Stimulates Its Enzymatic Activity

(2009) Siobhan Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ

(2009) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL