AMPK inhibition induces MCL1 mRNA destabilization via the p38 MAPK/miR-22/HuR axis in chronic myeloid leukemia cells

AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

(2022) Adrien Grenier et al.   Cell Reports

Asciminib: new therapeutic option in chronic phase CML with treatment failure.

(2022) David T Yeung et al.   BLOOD

Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring

(2022) Elias Jabbour et al.   AMERICAN JOURNAL OF HEMATOLOGY

BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells

(2022) Jing-Ting Chiou et al.   CHEMICO-BIOLOGICAL INTERACTIONS

New insights into activation and function of the AMPK

(2022) Gregory R. Steinberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation

(2021) Yi Ren et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMPK signaling and its targeting in cancer progression and treatment

(2021) Che-Chia Hsu et al.   SEMINARS IN CANCER BIOLOGY

Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells

(2021) Alena Malyukova et al.   Cell Death & Disease

Compound C induces autophagy and apoptosis in parental and hydroquinone-selected malignant leukemia cells through the ROS/p38 MAPK/AMPK/TET2/FOXP3 axis

(2020) Jing-Ting Chiou et al.   CELL BIOLOGY AND TOXICOLOGY

Response and Resistance to BCR-ABL1-Targeted Therapies

(2020) Theodore P. Braun et al.   CANCER CELL

Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression

(2020) Liang-Jun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK activation primes cytoplasmic translocation and autophagic degradation of the BCR‐ABL protein in CML cells

(2020) Daisuke Koyama et al.   CANCER SCIENCE

SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation

(2019) Jiao Ma et al.   BRITISH JOURNAL OF HAEMATOLOGY

Autophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155-treated human leukemia cells

(2019) Jing-Ting Chiou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ABT-263-induced MCL1 upregulation depends on autophagy-mediated 4EBP1 downregulation in human leukemia cells

(2018) Yuan-Chin Lee et al.   CANCER LETTERS

Compound C induces protective autophagy in human cholangiocarcinoma cells via Akt/mTOR-independent pathway

(2018) Xiaofang Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer

(2018) Yanqing Liu et al.   Molecular Cancer

mTOR Pathways in Cancer and Autophagy

(2018) Mathieu Paquette et al.   Cancers

Alternating Magnetic Field (AMF) Enhances Cytotoxicity of Compound C

(2018) Taisuke Akimoto et al.   CANCER SCIENCE

Genomic amplification of BCR-ABL1 fusion gene and its impact on the disease progression mechanism in patients with chronic myelogenous leukemia

(2018) Ramachandran Krishna Chandran et al.   GENE

The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection

(2017) Florian Ebner et al.   JOURNAL OF CLINICAL INVESTIGATION

Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production

(2016) Kyuhwa Seo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia

(2016) Aimin Qiao et al.   Oncotarget

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow

(2015) Yusuke Saito et al.   Cell Stem Cell

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic myeloid leukaemia

(2015) Jane F Apperley   LANCET

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

(2014) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Differential effects of AMPK agonists on cell growth and metabolism

(2014) E E Vincent et al.   ONCOGENE

Targeting BCL2 for the Treatment of Lymphoid Malignancies

(2014) Mary Ann Anderson et al.   SEMINARS IN HEMATOLOGY

Implication of transcriptional repression in compound C-induced apoptosis in cancer cells

(2013) R Y Dai et al.   Cell Death & Disease

AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells

(2012) B Accordi et al.   LEUKEMIA

Gallic acid downregulates matrix metalloproteinase-2 (MMP-2) and MMP-9 in human leukemia cells with expressed Bcr/Abl

(2012) Ying-Jung Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

(2011) Noriko Handa et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Adaphostin promotes caffeine-evoked autocrine Fas-mediated death pathway activation in Bcr/Abl-positive leukaemia cells

(2011) Wen-Hsin Liu et al.   BIOCHEMICAL JOURNAL

Antileukemic effects of AMPK activators on BCR-ABL-expressing cells

(2011) E. Vakana et al.   BLOOD

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance

(2011) N. Filippova et al.   MOLECULAR CANCER RESEARCH

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway

(2010) Ljubica Vucicevic et al.   Autophagy

Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1

(2010) Ji Hoon Jang et al.   EXPERIMENTAL CELL RESEARCH

Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines

(2010) Anna Virgili et al.   Molecular Cytogenetics

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells

(2009) Junfei Jin et al.   JOURNAL OF LIPID RESEARCH

Regulation of H2O2-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes

(2008) Behnam Saberi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The complexity of mitogen-activated protein kinases (MAPKs) made simple

(2008) M. Krishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES