BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells

Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL

(2021) Marco Haselager et al.   CELL DEATH AND DIFFERENTIATION

The application of BH3 mimetics in myeloid leukemias

(2021) Narissa Parry et al.   Cell Death & Disease

It's time to die: BH3 mimetics in solid tumors

(2021) Sarah Kehr et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NOXA‐mediated degradation of MCL1 and BCL2L1 causes apoptosis of daunorubicin‐treated human acute myeloid leukemia cells

(2021) Jing‐Ting Chiou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting MCL-1 in cancer: current status and perspectives

(2021) Haolan Wang et al.   Journal of Hematology & Oncology

Selectivity of mRNA degradation by autophagy in yeast

(2021) Shiho Makino et al.   Nature Communications

Inhibition of Sp1-mediated survivin and MCL1 expression cooperates with SLC35F2 and myeloperoxidase to modulate YM155 cytotoxicity to human leukemia cells

(2021) Jing-Ting Chiou et al.   BIOCHEMICAL PHARMACOLOGY

BCL2 inhibitors and MCL1 inhibitors for hematological malignancies

(2021) Andrew W. Roberts et al.   BLOOD

Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis

(2021) Jing-Ting Chiou et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Transcript-Level Dysregulation of BCL2 Family Genes in Acute Myeloblastic Leukemia

(2021) Luiza Handschuh et al.   Cancers

Targeting MCL-1 in hematologic malignancies: Rationale and progress

(2020) AndrewH. Wei et al.   BLOOD REVIEWS

Compound C induces autophagy and apoptosis in parental and hydroquinone-selected malignant leukemia cells through the ROS/p38 MAPK/AMPK/TET2/FOXP3 axis

(2020) Jing-Ting Chiou et al.   CELL BIOLOGY AND TOXICOLOGY

NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer

(2020) Gertrud Knoll et al.   Cell Death & Disease

Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer

(2020) Simona D’Aguanno et al.   Cells

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells

(2020) Ali Alhoshani et al.   OncoTargets and Therapy

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

(2019) Mariana Villalobos-Ortiz et al.   CELL DEATH AND DIFFERENTIATION

Autophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155-treated human leukemia cells

(2019) Jing-Ting Chiou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ABT-263-induced MCL1 upregulation depends on autophagy-mediated 4EBP1 downregulation in human leukemia cells

(2018) Yuan-Chin Lee et al.   CANCER LETTERS

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose

(2018) Federico Lucantoni et al.   Oncotarget

The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells

(2018) Ying-Jung Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

(2018) Ryan S. Soderquist et al.   Nature Communications

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

(2018) Delphine Merino et al.   CANCER CELL

Role of Noxa in proliferation, apoptosis, and autophagy in human adenoid cystic carcinoma

(2018) Lizhong Liang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation

(2017) Chia-Hui Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

(2017) Karthigayan Shanmugasundaram et al.   Nature Communications

Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells

(2016) Ying-Jung Chen et al.   ARCHIVES OF TOXICOLOGY

Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling

(2016) Victor Peperzak et al.   CELL DEATH AND DIFFERENTIATION

Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models

(2016) E. A. Punnoose et al.   MOLECULAR CANCER THERAPEUTICS

Venetoclax (ABT-199) Might Act as a Perpetrator in Pharmacokinetic Drug–Drug Interactions

(2016) Johanna Weiss et al.   Pharmaceutics

BH3-only proteins: a 20-year stock-take

(2015) Marcel Doerflinger et al.   FEBS Journal

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

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MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies

(2015) G S Choudhary et al.   Cell Death & Disease

NOX4 regulates autophagy during energy deprivation

(2014) Sebastiano Sciarretta et al.   Autophagy

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak

(2014) L. M. Lindqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting BCL2 for the Treatment of Lymphoid Malignancies

(2014) Mary Ann Anderson et al.   SEMINARS IN HEMATOLOGY

The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA

(2013) Ryan Soderquist et al.   APOPTOSIS

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Structure-guided design of a selective BCL-XL inhibitor

(2013) Guillaume Lessene et al.   Nature Chemical Biology

Transcription Factors Sp1 and p73 Control the Expression of the Proapoptotic Protein NOXA in the Response of Testicular Embryonal Carcinoma Cells to Cisplatin

(2012) Lara Grande et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment

(2011) C. M. McHale et al.   CARCINOGENESIS

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Bcl2 family proteins in carcinogenesis and the treatment of cancer

(2009) Anna Frenzel et al.   APOPTOSIS

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE