Compound C induces autophagy and apoptosis in parental and hydroquinone-selected malignant leukemia cells through the ROS/p38 MAPK/AMPK/TET2/FOXP3 axis

Compound C induces protective autophagy in human cholangiocarcinoma cells via Akt/mTOR-independent pathway

(2018) Xiaofang Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of β-catenin signaling

(2018) Jiaqi Li et al.   TOXICOLOGY IN VITRO

mTOR Pathways in Cancer and Autophagy

(2018) Mathieu Paquette et al.   Cancers

mTOR Cross-Talk in Cancer and Potential for Combination Therapy

(2018) Fabiana Conciatori et al.   Cancers

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

(2018) Di Wu et al.   NATURE

The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells

(2018) Ying-Jung Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AMPK contributes to autophagosome maturation and lysosomal fusion

(2018) Minsu Jang et al.   Scientific Reports

AMPK: An Epigenetic Landscape Modulator

(2018) Brendan Gongol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Benzene induces haematotoxicity by promoting deacetylation and autophagy

(2018) Shanhu Qian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death

(2017) Longmei Xu et al.   TOXICOLOGY IN VITRO

PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

(2017) Xi Zhang et al.   Stem Cell Reports

Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells

(2016) Ying-Jung Chen et al.   ARCHIVES OF TOXICOLOGY

The impact of endurance exercise on global and AMPK gene-specific DNA methylation

(2016) Tanya S. King-Himmelreich et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population-based study

(2016) Jenny N. Poynter et al.   INTERNATIONAL JOURNAL OF CANCER

5-azacytidine affects TET2 and histone transcription and reshapes morphology of human skin fibroblasts

(2016) Elena F. M. Manzoni et al.   Scientific Reports

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow

(2015) Yusuke Saito et al.   Cell Stem Cell

Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

(2015) Ruili Yang et al.   IMMUNITY

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia

(2015) Pierre Sujobert et al.   Cell Reports

The possible role of liver kinase B1 in hydroquinone-induced toxicity of murine fetal liver and bone marrow hematopoietic stem cells

(2014) Zhen Li et al.   ENVIRONMENTAL TOXICOLOGY

Direct Binding of Arsenic Trioxide to AMPK and Generation of Inhibitory Effects on Acute Myeloid Leukemia Precursors

(2014) E. M. Beauchamp et al.   MOLECULAR CANCER THERAPEUTICS

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

(2014) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

AMPK: A Contextual Oncogene or Tumor Suppressor?

(2013) J. Liang et al.   CANCER RESEARCH

p38 MAPK/PP2Acα/TTP pathway on the connection of TNF-α and caspases activation on hydroquinone-induced apoptosis

(2013) Wen-Hsin Liu et al.   CARCINOGENESIS

Hydroquinone Increases 5-Hydroxymethylcytosine Formation through Ten Eleven Translocation 1 (TET1) 5-Methylcytosine Dioxygenase

(2013) Jonathan B. Coulter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells

(2012) B Accordi et al.   LEUKEMIA

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of benzene and its metabolites on global DNA methylation in human normal hepatic l02 cells

(2011) Junjie Hu et al.   ENVIRONMENTAL TOXICOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Advances in Understanding Benzene Health Effects and Susceptibility

(2010) Martyn T. Smith   Annual Review of Public Health

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway

(2010) Ljubica Vucicevic et al.   Autophagy

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Akt Cys-310-targeted Inhibition by Hydroxylated Benzene Derivatives Is Tightly Linked to Their Immunosuppressive Effects

(2010) Ji Yeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway

(2010) Wen-Hsin Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide

(2010) Z Ji et al.   LEUKEMIA

In VivoStructure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors

(2009) Jijun Hao et al.   ACS Chemical Biology

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells

(2009) Junfei Jin et al.   JOURNAL OF LIPID RESEARCH

Hydroquinone, a major component in cigarette smoke, reduces IFN-γ production in antigen-primed lymphocytes

(2008) Jin Myung Choi et al.   ARCHIVES OF PHARMACAL RESEARCH