Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons

Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex

(2022) Evelien Van Schoor et al.   ACTA NEUROPATHOLOGICA

Pyroptosis executive protein GSDMD as a biomarker for diagnosis and identification of Alzheimer’s disease

(2021) Heping Shen et al.   Brain and Behavior

Senescent Microglia: The Key to the Ageing Brain?

(2021) Eleanor K. Greenwood et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults

(2021) Jolien M. Schaeverbeke et al.   Alzheimers Research & Therapy

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology

(2021) Yanling Hu et al.   Cell Reports

Molecular and structural aspects of gasdermin family pores and insights into gasdermin-elicited programmed cell death

(2021) Ayesha Zahid et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

(2020) Annerieke Sierksma et al.   EMBO Molecular Medicine

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

(2020) Lea L. Friker et al.   Cell Reports

New mechanism of nerve injury in Alzheimer’s disease: β‐amyloid‐induced neuronal pyroptosis

(2020) Chenyang Han et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

(2020) Xinwen Zhang et al.   Science Advances

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

(2019) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

(2019) Vera I. Wiersma et al.   ACTA NEUROPATHOLOGICA

Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein

(2019) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

The neuroprotection of progesterone against Aβ-induced NLRP3-Caspase-1 inflammasome activation via enhancing autophagy in astrocytes

(2019) Yang Hong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Cell’s Fate: An Overview of the Molecular Biology and Genetics of Apoptosis

(2019) Giovanna C. Cavalcante et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

(2019) Marta J. Koper et al.   ACTA NEUROPATHOLOGICA

Capillary cerebral amyloid angiopathy in Alzheimer’s disease: association with allocortical/hippocampal microinfarcts and cognitive decline

(2018) Moritz Hecht et al.   ACTA NEUROPATHOLOGICA

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

(2018) Nathalia M. de Vasconcelos et al.   CELL DEATH AND DIFFERENTIATION

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Fe3+ Facilitates Endocytic Internalization of Extracellular Aβ1–42 and Enhances Aβ1–42-Induced Caspase-3/Caspase-4 Activation and Neuronal Cell Death

(2018) Tomoyuki Nishizaki   MOLECULAR NEUROBIOLOGY

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Necroptosis activation in Alzheimer's disease

(2017) Antonella Caccamo et al.   NATURE NEUROSCIENCE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

(2017) Limin Song et al.   Frontiers in Cellular Neuroscience

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

The human-specificCASP4gene product contributes to Alzheimer-related synaptic and behavioural deficits

(2016) Yuji Kajiwara et al.   HUMAN MOLECULAR GENETICS

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Distinction of Neurons, Glia and Endothelial Cells in the Cerebral Cortex: An Algorithm Based on Cytological Features

(2016) Miguel Á. García-Cabezas et al.   Frontiers in Neuroanatomy

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model

(2015) Adib Zendedel et al.   MOLECULAR NEUROBIOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis

(2014) Christoph Köhler et al.   NEUROBIOLOGY OF DISEASE

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress response

(2011) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice

(2011) Harshvardhan Rolyan et al.   BRAIN

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY