Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex

Inflammasome in ALS Skeletal Muscle: NLRP3 as a Potential Biomarker

(2021) Leticia Moreno-García et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis

(2021) Poulomi Banerjee et al.   JOURNAL OF PATHOLOGY

Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases

(2020) Yadi Guan et al.   Frontiers in Integrative Neuroscience

Necrosome‐positive granulovacuolar degeneration is associated with TDP‐43 pathological lesions in the hippocampus of ALS/FTLD cases

(2020) E. Van Schoor et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

(2020) Xinwen Zhang et al.   Science Advances

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

(2019) Marlijn van der Poel et al.   Nature Communications

Heterogeneity of microglia and their differential roles in white matter pathology

(2019) Janice Lee et al.   CNS Neuroscience & Therapeutics

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

(2019) Vandana Deora et al.   GLIA

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

(2019) Marta J. Koper et al.   ACTA NEUROPATHOLOGICA

α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome

(2019) Xiaohong Wang et al.   Experimental and Therapeutic Medicine

Pathomechanisms of TDP-43 in neurodegeneration

(2018) Ju Gao et al.   JOURNAL OF NEUROCHEMISTRY

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Contribution of the inflammasome to inflammaging

(2018) Nancy H. Mejias et al.   Journal of Inflammation-London

Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia

(2017) María M. Leal-Lasarte et al.   FASEB JOURNAL

NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model

(2017) Agnese Gugliandolo et al.   INFLAMMATION

Epidemiology of amyotrophic lateral sclerosis in Southern Germany

(2017) Angela Rosenbohm et al.   JOURNAL OF NEUROLOGY

Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis

(2017) Ilaria Bellezza et al.   MOLECULAR NEUROBIOLOGY

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

(2017) Limin Song et al.   Frontiers in Cellular Neuroscience

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms

(2016) Hazim Kadhim et al.   MEDICAL HYPOTHESES

Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders

(2016) Wen Zhang et al.   NATURE NEUROSCIENCE

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

(2016) Keren Zhou et al.   Journal of Immunology Research

Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS

(2016) Junghee Lee et al.   Experimental Neurobiology

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

(2015) Weihua Zhao et al.   EXPERIMENTAL NEUROLOGY

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders

(2015) Francisco Espejo-Porras et al.   Journal of Neuroimmune Pharmacology

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

(2015) Emma L. Scotter et al.   Neurotherapeutics

TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation

(2015) Jingyan Zhu et al.   PLoS One

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis

(2014) Paola Italiani et al.   Journal of Neuroinflammation

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice

(2014) Sarah Herdewyn et al.   Molecular Neurodegeneration

The phenotypic variability of amyotrophic lateral sclerosis

(2014) Bart Swinnen et al.   Nature Reviews Neurology

Sleep promotes branch-specific formation of dendritic spines after learning

(2014) G. Yang et al.   SCIENCE

C57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS

(2013) Theo Hatzipetros et al.   BRAIN RESEARCH

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Frequency of C9orf72 repeat expansions in amyotrophic lateral sclerosis: a Belgian cohort study

(2013) Sarah Debray et al.   NEUROBIOLOGY OF AGING

Caspase-1: is IL-1 just the tip of the ICEberg?

(2012) A Denes et al.   Cell Death & Disease

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Classification of primary progressive aphasia and its variants

(2011) M. L. Gorno-Tempini et al.   NEUROLOGY

Mutant superoxide dismutase 1-induced IL-1  accelerates ALS pathogenesis

(2010) F. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Awaji diagnostic algorithm increases sensitivity of El Escorial criteria for ALS diagnosis

(2008) Mamede De Carvalho et al.   Amyotrophic Lateral Sclerosis

Electrodiagnostic criteria for diagnosis of ALS

(2008) Mamede de Carvalho et al.   CLINICAL NEUROPHYSIOLOGY