CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice

The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish

(2022) Marialuisa Aragona et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6

(2022) Devon Jeltema et al.   JOURNAL OF IMMUNOLOGY

Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases

(2022) Christophe Paget et al.   Cells

IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression

(2022) Man-Man Zhang et al.   Cell and Bioscience

Histamine H3R antagonist counteracts the impaired hippocampal neurogenesis in Lipopolysaccharide-induced neuroinflammation

(2022) Jiangong Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

(2021) Yuanjie Li et al.   Journal of Neuroinflammation

Cellular Senescence in Brain Aging

(2021) Ewa Sikora et al.   Frontiers in Aging Neuroscience

Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease

(2021) Yinyin Tan et al.   Cell and Bioscience

Temporal and Spatial Dynamics of Inflammasome Activation After Ischemic Stroke

(2021) Danli Lu et al.   Frontiers in Neurology

IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis

(2021) Jinqiang Zhang et al.   Science Advances

Microglial morphology in Alzheimer’s disease and after Aβ immunotherapy

(2021) Diana K. Franco-Bocanegra et al.   Scientific Reports

Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update

(2021) Qingying Yu et al.   Frontiers in Pharmacology

Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype

(2021) Natalie Prowse et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Inhibition of the NLRP3 inflammasome with MCC950 prevents chronic social isolation-induced depression-like behavior in male mice

(2021) Wei Li et al.   NEUROSCIENCE LETTERS

Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration

(2021) Meenakshi Ambati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches

(2021) Gozal Bahlakeh et al.   Cell and Bioscience

Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models

(2021) Andrea Nieto-Quero et al.   Neurobiology of Stress

Cathelicidin‐related antimicrobial peptide protects against ischaemia reperfusion‐induced acute kidney injury in mice

(2020) Li‐Long Pan et al.   BRITISH JOURNAL OF PHARMACOLOGY

P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes

(2020) Danwen Wang et al.   Cell and Bioscience

Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder

(2020) Haihua Tian et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Sleeve Gastroplasty Combined with the NLRP3 Inflammasome Inhibitor CY-09 Reduces Body Weight, Improves Insulin Resistance and Alleviates Hepatic Steatosis in Mouse Model

(2020) Kangyue Sun et al.   OBESITY SURGERY

Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?

(2020) Carolina Pellegrini et al.   PROGRESS IN NEUROBIOLOGY

LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression

(2020) Jialei Zhu et al.   BIOSCIENCE REPORTS

BDNF reverses aging-related microglial activation

(2020) Shih-Ying Wu et al.   Journal of Neuroinflammation

Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole

(2020) Kai Shen et al.   Current Molecular Pharmacology

Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression

(2020) Weifen Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Maternal immune activation-induced PPARγ-dependent dysfunction of microglia associated with neurogenic impairment and aberrant postnatal behaviors in offspring

(2019) Qiuying Zhao et al.   NEUROBIOLOGY OF DISEASE

The Role of Inflammation in Depression and Fatigue

(2019) Chieh-Hsin Lee et al.   Frontiers in Immunology

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

The Association of Major Depressive Disorder with Activation of NLRP3 Inflammasome, Lipid Peroxidation, and Total Antioxidant Capacity

(2019) Abdolghader Taene et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Changes in the global burden of depression from 1990 to 2017: Findings from the Global Burden of Disease study

(2019) Qingqing Liu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Control of the inflammasome by the ubiquitin system

(2019) Gloria Lopez‐Castejon   FEBS Journal

Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice

(2018) Ze-Qun Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

Sucrose preference test for measurement of stress-induced anhedonia in mice

(2018) Meng-Ying Liu et al.   Nature Protocols

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway

(2018) Lang Zhang et al.   BRAIN RESEARCH BULLETIN

Immune cells and CNS physiology: Microglia and beyond

(2018) Geoffrey T. Norris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

(2018) Lijuan Zhang et al.   Frontiers in Cellular Neuroscience

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

(2017) Wei Zhu et al.   NEUROSCIENCE

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder

(2017) Elísabet Alcocer-Gómez et al.   PHARMACOLOGICAL RESEARCH

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

(2016) Ji-chun Zhang et al.   Current Neuropharmacology

The Indispensable Roles of Microglia and Astrocytes during Brain Development

(2016) Kitty Reemst et al.   Frontiers in Human Neuroscience

NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis

(2016) Shigehiro Itani et al.   Scientific Reports

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

(2015) Dora Brites et al.   Frontiers in Cellular Neuroscience

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Inflammatory Factors Contribute to Depression and Its Comorbid Conditions

(2012) H. Anisman et al.   Science Signaling

BDNF-restricted knockout mice as an animal model for aggression

(2011) W. Ito et al.   GENES BRAIN AND BEHAVIOR

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY