Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update

Gout

(2021) Nicola Dalbeth et al.   LANCET

MiR‐29c‐3p inhibits microglial NLRP3 inflammasome activation by targeting NFAT5 in Parkinson's disease

(2020) Ruili Wang et al.   GENES TO CELLS

Global mapping of interventions to improve quality of life of patients with depression during 1990–2018

(2020) Bach Xuan Tran et al.   QUALITY OF LIFE RESEARCH

MicroRNA-135b alleviates MPP+-mediated Parkinson’s disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis

(2019) Rong Zeng et al.   JOURNAL OF CLINICAL NEUROSCIENCE

MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model

(2019) Qiang Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease

(2019) Jianzhong Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson’s disease models

(2019) Xinyu Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

(2018) Yu Gao et al.   Current Alzheimer Research

Corrigendum to “Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke” [Free Radic. Biol. Med. 104 (2017) 333–345]

(2018) Yuan-Yuan Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Yangzheng Sanjie Decoction-containing serum mediated by microRNA-7 on cell proliferation and apoptosis in gastric cancer

(2018) Wanqun Chen et al.   Oncology Letters

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages

(2018) Eduardo P. Amaral et al.   Frontiers in Immunology

ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection

(2018) Seungyeop Lee et al.   Frontiers in Immunology

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

(2017) Xinchun Ye et al.   EXPERIMENTAL NEUROLOGY

Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses

(2017) Young-Su Yi   IMMUNOLOGY

Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion

(2017) Xiujian Xu et al.   INFLAMMATION RESEARCH

Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro

(2017) Biqiong Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats

(2017) Chang Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

(2017) Qi He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ginsenoside Rg1 protects against neuronal degeneration induced by chronic dexamethasone treatment by inhibiting NLRP-1 inflammasomes in mice

(2017) Yaodong Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Role of NLRP3 Inflammasomes in Atherosclerosis

(2017) Tadayoshi Karasawa et al.   Journal of Atherosclerosis and Thrombosis

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation

(2017) Gregory M. Orlowski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage

(2017) Biqiong Zhang et al.   Journal of Neuroinflammation

Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia

(2017) Zheng Fan et al.   Journal of Neuroinflammation

Inflammasome antagonism by human parainfluenza virus type 3 C protein

(2017) Niraj K. Shil et al.   JOURNAL OF VIROLOGY

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway

(2017) Juan Peng et al.   MOLECULAR IMMUNOLOGY

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3

(2017) Dongsheng Li et al.   Human Cell

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

(2017) Shenglong Cao et al.   Scientific Reports

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome

(2017) Laura R. Hoyt et al.   Redox Biology

Immunology of Major Depression

(2017) Norbert Müller   NEUROIMMUNOMODULATION

Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain

(2016) Ruipeng Li et al.   BEHAVIOURAL BRAIN RESEARCH

Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation

(2016) Xiuting Liu et al.   BIOCHEMICAL PHARMACOLOGY

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice

(2016) Yongjun Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

The anti-inflammatory effects of baicalin through suppression of NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

(2016) Chun Ye et al.   Innate Immunity

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

(2016) Jing Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression

(2016) Ren-Hong Du et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH

(2016) Sheng-Tao Yao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

(2016) Yushu Dong et al.   JOURNAL OF PINEAL RESEARCH

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Integrating neuroimmune systems in the neurobiology of depression

(2016) Eric S. Wohleb et al.   NATURE REVIEWS NEUROSCIENCE

Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation

(2016) Takahiko Imai et al.   NEUROBIOLOGY OF DISEASE

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke

(2016) Yunnan Lu et al.   NEUROIMMUNOMODULATION

Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

(2016) Nanhong Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice

(2016) Takuma Kuroki et al.   STROKE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

The Immune System and the Role of Inflammation in Perinatal Depression

(2016) Philippe Leff-Gelman et al.   Neuroscience Bulletin

The inflammasome: an emerging therapeutic oncotarget for cancer prevention

(2016) Wang Zhiyu et al.   Oncotarget

Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice

(2015) Xue-Yang Deng et al.   BEHAVIOURAL BRAIN RESEARCH

A new pharmacological effect of levornidazole: Inhibition of NLRP3 inflammasome activation

(2015) Xingqi Wang et al.   BIOCHEMICAL PHARMACOLOGY

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

(2015) Sunny Malhotra et al.   BRAIN

Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth

(2015) Margaret Tartter et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

(2015) Marina A Lynch   BRAIN RESEARCH

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2

(2015) Venugopal Rajanbabu et al.   CELLULAR IMMUNOLOGY

Hyperbaric oxygen preconditioning attenuates hemorrhagic transformation through increasing PPARγ in hyperglycemic MCAO rats

(2015) Hetao Bian et al.   EXPERIMENTAL NEUROLOGY

Role of Inflammasomes in Intestinal Inflammation and Crohnʼs Disease

(2015) Anthony Opipari et al.   INFLAMMATORY BOWEL DISEASES

NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation

(2015) Y. Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

(2015) Nils Schallner et al.   JOURNAL OF CLINICAL INVESTIGATION

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

Recombinant adenovirus encoding NLRP3 RNAi attenuate inflammation and brain injury after intracerebral hemorrhage

(2015) Bangqing Yuan et al.   JOURNAL OF NEUROIMMUNOLOGY

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies

(2015) Gislaine Z. Réus et al.   JOURNAL OF PSYCHIATRIC RESEARCH

IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations

(2015) Hyun-Jung Park et al.   MEDIATORS OF INFLAMMATION

MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage

(2015) Zhao Yang et al.   MOLECULAR IMMUNOLOGY

Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage

(2015) Jianru Li et al.   MOLECULAR NEUROBIOLOGY

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

(2015) Elísabet Alcocer-Gómez et al.   MOLECULAR NEUROBIOLOGY

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome

(2015) Anwen Shao et al.   MOLECULAR NEUROBIOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency

(2015) Martin Bogale Ystgaard et al.   Neonatology

NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

(2015) Liuji Chen et al.   NEUROBIOLOGY OF AGING

Toll-like receptor-4-mediated autophagy contributes to microglial activation and inflammatory injury in mouse models of intracerebral haemorrhage

(2015) Zhao Yang et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

(2015) Susan L. Patterson   NEUROPHARMACOLOGY

Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

(2015) B. Liu et al.   NEUROSCIENCE

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

l-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters

(2015) Jinsong Xue et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

(2015) Xue-Yang Deng et al.   PHYSIOLOGY & BEHAVIOR

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Vascular Normalization Induced by Sinomenine Hydrochloride Results in Suppressed Mammary Tumor Growth and Metastasis

(2015) Huimin Zhang et al.   Scientific Reports

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Toll-like receptor 2/4 heterodimer mediates inflammatory injury in intracerebral hemorrhage

(2014) Yan-Chun Wang et al.   ANNALS OF NEUROLOGY

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Expression of Toll-Like Receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder

(2014) Szabolcs Kéri et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 Inflammasome: A New Target in Major Depressive Disorder

(2014) Elísabet Alcocer-Gómez et al.   CNS Neuroscience & Therapeutics

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

(2014) R. Allam et al.   EMBO REPORTS

Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice

(2014) Kunjbihari Sulakhiya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intermittent fasting attenuates inflammasome activity in ischemic stroke

(2014) David Yang-Wei Fann et al.   EXPERIMENTAL NEUROLOGY

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

(2014) Nan Zhang et al.   MEDIATORS OF INFLAMMATION

Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases

(2014) Alexander J.S. Choi et al.   MOLECULES AND CELLS

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Aminoguanidine treatment ameliorates inflammatory responses and memory impairment induced by amyloid-beta 25–35 injection in rats

(2014) Alfonso Díaz et al.   NEUROPEPTIDES

Erratum: Intra-Hippocampal Transplantation of Neural Precursor Cells with Transgenic Over-Expression of IL-1 Receptor Antagonist Rescues Memory and Neurogenesis Impairments in an Alzheimer’s Disease Model

(2014) Ofra Ben Menachem-Zidon et al.   NEUROPSYCHOPHARMACOLOGY

The role of the neuroendocrine and immune systems in the pathogenesis of depression

(2014) Ewa Ogłodek et al.   Pharmacological Reports

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

(2014) George M. Slavich et al.   PSYCHOLOGICAL BULLETIN

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Hypoglycemic and anti-depressant effects of Zuogui Jiangtang Jieyu formulation in a model of unpredictable chronic mild stress in rats with diabetes mellitus

(2014) YU-HONG WANG et al.   Experimental and Therapeutic Medicine

Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

(2014) Wanwan Huai et al.   Nature Communications

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder

(2014) JiaJun Liu et al.   Frontiers in Neuroscience

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage

(2013) Qingyi Ma et al.   ANNALS OF NEUROLOGY

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Love and death: microglia, NLRP3 and the Alzheimer's brain

(2013) Tobias Goldmann et al.   CELL RESEARCH

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans

(2013) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prognosis of Intracerebral Hemorrhage after Conservative Treatment

(2013) Mohamed Al-Khaled et al.   Journal of Stroke & Cerebrovascular Diseases

Delayed neurological deterioration after subarachnoid haemorrhage

(2013) R. Loch Macdonald   Nature Reviews Neurology

Progress in translational research on intracerebral hemorrhage: Is there an end in sight?

(2013) Guohua Xi et al.   PROGRESS IN NEUROBIOLOGY

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

(2013) Yu Zhou et al.   PROGRESS IN NEUROBIOLOGY

Rift Valley fever virus infection induces activation of the NLRP3 inflammasome

(2013) Megan E. Ermler et al.   VIROLOGY

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease

(2013) B Parajuli et al.   Cell Death & Disease

The role of immune genes in the association between depression and inflammation: A review of recent clinical studies

(2012) Chiara Bufalino et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

(2012) Kate Schroder et al.   IMMUNOBIOLOGY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

(2009) Jessica Chu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology

(2008) Antero Salminen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY