Intracellular signalling during neutrophil recruitment

Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies

(2015) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis

(2015) Xuehua Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

(2015) Monika Pruenster et al.   Nature Communications

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Social networking of human neutrophils within the immune system

(2014) P. Scapini et al.   BLOOD

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis

(2014) Chinmay R. Surve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

(2014) Miklós Kovács et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase

(2014) Kyoung-Jin Chung et al.   MOLECULAR BIOLOGY OF THE CELL

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease

(2014) J. Charles Jennette et al.   Nature Reviews Rheumatology

New players in haemostasis and thrombosis

(2014) Julia Geddings et al.   THROMBOSIS AND HAEMOSTASIS

Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling

(2013) J. M. Herter et al.   BLOOD

Coordinated and unique functions of the E-selectin ligand ESL-1 during inflammatory and hematopoietic recruitment in mice

(2013) V. Sreeramkumar et al.   BLOOD

Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response

(2013) S. M. Jakob et al.   BLOOD

The Subcellular Localization of the Receptor for Platelet-Activating Factor in Neutrophils Affects Signaling and Activation Characteristics

(2013) Emil Andréasson et al.   Clinical & Developmental Immunology

Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking

(2013) Dong Soo Kang et al.   CURRENT OPINION IN CELL BIOLOGY

Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis

(2013) Jose A. Gomez-Puerta et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

(2013) Attila Mócsai   JOURNAL OF EXPERIMENTAL MEDICINE

Integrin Regulation during Leukocyte Recruitment

(2013) J. Herter et al.   JOURNAL OF IMMUNOLOGY

Control of Myeloid Cell Trafficking in Resolution

(2013) Lucy V. Norling et al.   Journal of Innate Immunity

Molecular players in neutrophil chemotaxis-focus on PI3K and small GTPases

(2013) Laure Gambardella et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils—A Key Component of Ischemia-Reperfusion Injury

(2013) Zoe Victoria Schofield et al.   SHOCK

Pathophysiological role of neutrophils in acute myocardial infarction

(2013) Federico Carbone et al.   THROMBOSIS AND HAEMOSTASIS

Neutrophil Chemotaxis within a Competing Gradient of Chemoattractants

(2012) Donghyuk Kim et al.   ANALYTICAL CHEMISTRY

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules

(2012) S. Kumar et al.   BLOOD

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Network Crosstalk Dynamically Changes during Neutrophil Polarization

(2012) Chin-Jen Ku et al.   CELL

LTB4 Is a Signal-Relay Molecule during Neutrophil Chemotaxis

(2012) Philippe V. Afonso et al.   DEVELOPMENTAL CELL

Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

(2012) Michiko K. Oyoshi et al.   IMMUNITY

The role of neutrophils in autoimmune diseases

(2012) Tamás Németh et al.   IMMUNOLOGY LETTERS

TAK1 contributes to the enhanced responsiveness of LTB4-treated neutrophils to Toll-like receptor ligands

(2012) E. Gaudreault et al.   INTERNATIONAL IMMUNOLOGY

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury

(2012) Helena Block et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphoinositide 3-OH Kinase Regulates Integrin-Dependent Processes in Neutrophils by Signaling through Its Effector ARAP3

(2012) L. Gambardella et al.   JOURNAL OF IMMUNOLOGY

Leukocyte Function Antigen-1, Kindlin-3, and Calcium Flux Orchestrate Neutrophil Recruitment during Inflammation

(2012) N. Dixit et al.   JOURNAL OF IMMUNOLOGY

The Mammalian Actin-Binding Protein 1 Is Critical for Spreading and Intraluminal Crawling of Neutrophils under Flow Conditions

(2012) I. Hepper et al.   JOURNAL OF IMMUNOLOGY

Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion

(2012) Subhanjan Mondal et al.   MOLECULAR BIOLOGY OF THE CELL

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

(2012) Ralph Thomas Böttcher et al.   NATURE CELL BIOLOGY

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and Fc R signaling

(2012) C. D. Sadik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil arrest by LFA-1 activation

(2012) Craig T. Lefort et al.   Frontiers in Immunology

Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest

(2012) Neha Dixit et al.   Frontiers in Immunology

Rac regulates PtdInsP3 signaling and the chemotactic compass through a redox-mediated feedback loop

(2011) J. W. P. Kuiper et al.   BLOOD

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions

(2011) C. Costa et al.   BLOOD

The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils

(2011) L. Gambardella et al.   BLOOD

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling

(2011) Anika Stadtmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deletion of Syk in Neutrophils Prevents Immune Complex Arthritis

(2011) Emily R. Elliott et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Cleavage of Annexin A1 by ADAM10 during Secondary Necrosis Generates a Monocytic "Find-Me" Signal

(2011) K. E. Blume et al.   JOURNAL OF IMMUNOLOGY

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

PI3K  Plays a Critical Role in Neutrophil Activation by Immune Complexes

(2011) S. Kulkarni et al.   Science Signaling

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

(2010) Y. Kuwano et al.   BLOOD

Mechanisms of force generation and force transmission during interstitial leukocyte migration

(2010) Jörg Renkawitz et al.   EMBO REPORTS

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

(2010) Richard C. Chou et al.   IMMUNITY

Neutrophil Functions and Autoimmune Arthritis in the Absence of p190RhoGAP: Generation and Analysis of a Novel Null Mutation in Mice

(2010) T. Nemeth et al.   JOURNAL OF IMMUNOLOGY

Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis

(2010) C. Carbo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

(2010) Sussan Nourshargh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions

(2009) E. Manevich-Mendelson et al.   BLOOD

A fundamental role of mAbp1 in neutrophils: impact on  2 integrin-mediated phagocytosis and adhesion in vivo

(2009) J. Schymeinsky et al.   BLOOD

Integrins in immunity

(2009) R. Evans et al.   JOURNAL OF CELL SCIENCE

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vav1 Is Essential for Mechanotactic Crawling and Migration of Neutrophils out of the Inflamed Microvasculature

(2009) M. Phillipson et al.   JOURNAL OF IMMUNOLOGY

Human Neutrophils Coordinate Chemotaxis by Differential Activation of Rac1 and Rac2

(2009) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

Adaptive force transmission in amoeboid cell migration

(2009) Jörg Renkawitz et al.   NATURE CELL BIOLOGY

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

(2009) A. Nishikimi et al.   SCIENCE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Vav/Phospholipase Cγ2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis

(2008) Viviana Cremasco et al.   ARTHRITIS AND RHEUMATISM

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

(2008) Braedon McDonald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE