Rac regulates PtdInsP3 signaling and the chemotactic compass through a redox-mediated feedback loop

Sbds is required for Rac2-mediated monocyte migration and signaling downstream of RANK during osteoclastogenesis

(2010) R. Leung et al.   BLOOD

Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis

(2010) Hidenori Hattori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Granulomatous Disease

(2009) Steven M. Holland   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Human Neutrophils Coordinate Chemotaxis by Differential Activation of Rac1 and Rac2

(2009) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation

(2009) B. Sarraj et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: Phospholipids determine net membrane surface charge resulting in differential localization of active Rac1 and Rac2

(2009) Marco A. O. Magalhaes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Chemotaxis: finding the way forward with Dictyostelium

(2009) Jason S. King et al.   TRENDS IN CELL BIOLOGY

The Signaling Mechanisms Underlying Cell Polarity and Chemotaxis

(2009) F. Wang   Cold Spring Harbor Perspectives in Biology

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP

(2008) B. Heit et al.   JOURNAL OF CELL SCIENCE

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

(2008) Bryan Heit et al.   NATURE IMMUNOLOGY

Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration

(2008) Takanari Inoue et al.   PLoS One

Feedback Loops Shape Cellular Signals in Space and Time

(2008) O. Brandman et al.   SCIENCE

p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration

(2008) Rachael E. Eckert et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY