The role of HMGB1/RAGE/TLR4 signaling pathways in cigarette smoke‐induced inflammation in chronic obstructive pulmonary disease

Role and mechanism of miR-181a-5p in mice with chronic obstructive pulmonary disease by regulating HMGB1 and the NF-κB pathway

(2022) Manyan Zhang et al.   CELLS TISSUES ORGANS

Endothelial Microparticles Derived from Primary Pulmonary Microvascular Endothelial Cells Mediate Lung Inflammation in Chronic Obstructive Pulmonary Disease by Transferring microRNA-126

(2022) Yiming Ma et al.   Journal of Inflammation Research

Ginsenoside Rb3 alleviates smoke‐induced lung injury via the H19/miR‐29b‐3p/HGMB1/TLR4 signalling pathway

(2021) Yan Tan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Expression of Toll-Like Receptor 4 mRNA in PBMCs Is Upregulated in Smokers and Decreases Upon Smoking Cessation

(2021) Hsin-Yu Yeh et al.   Frontiers in Immunology

RAGE-mediated functional DNA methylated modification contributes to cigarette smoke-induced airway inflammation in mice

(2021) Ping Li et al.   BIOSCIENCE REPORTS

Circ-HACE1 Aggravates Cigarette Smoke Extract-Induced Injury in Human Bronchial Epithelial Cells via Regulating Toll-Like Receptor 4 by Sponging miR-485-3p

(2021) Fujun Zhou et al.   International Journal of Chronic Obstructive Pulmonary Disease

Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines

(2020) Rongjun Wan et al.   Aging-US

HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells

(2020) Yuki Kodera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Gly82Ser mutation in AGER contributes to pathogenesis of pulmonary fibrosis in combined pulmonary fibrosis and emphysema (CPFE) in Japanese patients

(2020) Takumi Kinjo et al.   Scientific Reports

Cyclic Peptide Extracts Derived From Pseudostellaria heterophylla Ameliorates COPD via Regulation of the TLR4/MyD88 Pathway Proteins

(2020) Feng Lu et al.   Frontiers in Pharmacology

The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2020) Karolina Sidletskaya et al.   International Journal of Chronic Obstructive Pulmonary Disease

RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD

(2020) Venkata Sita Rama Raju Allam et al.   ALLERGY

Role of Atypical Chemokines and Chemokine Receptors Pathways In the Pathogenesis of Copd

(2020) Francesco Nucera et al.   CURRENT MEDICINAL CHEMISTRY

Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

(2020) Bo Ding et al.   Journal of Neuroinflammation

BMSC-derived exosomes alleviate smoke inhalation lung injury through blockade of the HMGB1/NF-κB pathway

(2020) Bin Xu et al.   LIFE SCIENCES

RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke

(2019) Karl A. Sanders et al.   Scientific Reports

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

(2019) Hongtao Niu et al.   Aging-US

One functional variant in the 3′‐untranslated region of TLR4 is associated with the elevated risk of ventilator‐associated pneumonia in the patients with chronic obstructive pulmonary disease

(2019) Xiaoyun Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Role of HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases

(2019) Mao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin-mediated disulfide bond formation is required for nucleocytoplasmic translocation and secretion of HMGB1 in response to inflammatory stimuli

(2019) Man Sup Kwak et al.   Redox Biology

Cigarette smoke‐induced HMGB1 translocation and release contribute to migration and NF‐κB activation through inducing autophagy in lung macrophages

(2019) Yanqing Le et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glycyrrhizin mitigates radiation‐induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway

(2019) Lei Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Functional variations of the TLR4 gene in association with chronic obstructive pulmonary disease and pulmonary tuberculosis

(2019) Zhongqi Li et al.   BMC Pulmonary Medicine

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice

(2019) Krishna Prahlad Maremanda et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PM2.5 Induced the Expression of Fibrogenic Mediators via HMGB1-RAGE Signaling in Human Airway Epithelial Cells

(2018) Weifeng Zou et al.   Canadian Respiratory Journal

MiR-27-3p regulates TLR2/4-dependent mouse alveolar macrophage activation by targetting PPARγ

(2018) Dan Wang et al.   CLINICAL SCIENCE

Genetic polymorphisms of IL17A , TLR4 and P2RX7 and associations with the risk of chronic obstructive pulmonary disease

(2018) Yaoyao Dai et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Inhibition of RAGE Attenuates Cigarette Smoke-Induced Lung Epithelial Cell Damage via RAGE-Mediated Nrf2/DAMP Signaling

(2018) Hanbyeol Lee et al.   Frontiers in Pharmacology

Role of inflammatory cells in airway remodeling in COPD

(2018) Yujie Wang et al.   International Journal of Chronic Obstructive Pulmonary Disease

Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression

(2017) Antonino Di Stefano et al.   EUROPEAN RESPIRATORY JOURNAL

Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling

(2017) Hanbyeol Lee et al.   FASEB JOURNAL

HMGB1 mediates Aspergillus fumigatus -induced inflammatory response in alveolar macrophages of COPD mice via activating MyD88/NF-κB and syk/PI3K signalings

(2017) Pengpeng Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

(2017) Sarang Tartey et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

HMGB1 translocation and release mediate cigarette smoke–induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway

(2017) Yao Cheng et al.   MOLECULAR BIOLOGY OF THE CELL

Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice

(2017) Xiao-Xi Lv et al.   Oncotarget

Emerging pharmaceutical therapies for COPD

(2017) Sowmya Lakshmi et al.   International Journal of Chronic Obstructive Pulmonary Disease

Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD

(2017) Wen Shen et al.   International Journal of Chronic Obstructive Pulmonary Disease

Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox

(2017) Mathew Suji Eapen et al.   Expert Review of Respiratory Medicine

RAGE inhibition reduces acute lung injury in mice

(2017) Raiko Blondonnet et al.   Scientific Reports

A systemic defect in Toll-like receptor 4 signaling increases lipopolysaccharide-induced suppression of IL-2-dependent T-cell proliferation in COPD

(2016) Jürgen Knobloch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

(2016) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Emerging role of HMGB1 in lung diseases: friend or foe

(2016) Junying Ding et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Translocation of Endogenous Danger Signal HMGB1 From Nucleus to Membrane Microvesicles in Macrophages

(2016) Yan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro

(2016) Suzanne Miller et al.   PLoS One

Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Biomarker of Emphysema and the RAGE Axis in the Lung

(2015) John G. Yonchuk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette Smoke–Induced Damage-Associated Molecular Pattern Release from Necrotic Neutrophils Triggers Proinflammatory Mediator Release

(2015) Irene H. Heijink et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients

(2015) S. D. Pouwels et al.   EUROPEAN RESPIRATORY JOURNAL

Association between HMGB1 and COPD: A Systematic Review

(2015) Sebastiano Gangemi et al.   MEDIATORS OF INFLAMMATION

RAGE-ligands axis: A new ‘driving force’ for cigarette smoke-induced airway inflammation in COPD?

(2015) Min Li et al.   RESPIROLOGY

Molecular Regulation of Toll-like Receptors in Asthma and COPD

(2015) Li Zuo et al.   Frontiers in Physiology

Chronic obstructive pulmonary disease

(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

The Receptor for Advanced Glycation End Products (RAGE) Contributes to the Progression of Emphysema in Mice

(2015) Nisha Sambamurthy et al.   PLoS One

Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene with COPD in the Chinese Population

(2014) You Li et al.   DNA AND CELL BIOLOGY

Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review

(2014) Ben Lu et al.   Expert Review of Clinical Immunology

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

Overexpression of RAGE Contributes to Cigarette Smoke-Induced Nitric Oxide Generation in COPD

(2014) Lei Chen et al.   LUNG

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Epidemiology and clinical impact of major comorbidities in patients with COPD

(2014) Miranda Smith et al.   International Journal of Chronic Obstructive Pulmonary Disease

Role of advanced glycation end products in cellular signaling

(2014) Christiane Ott et al.   Redox Biology

Conditional Overexpression of Receptors for Advanced Glycation End-Products in the Adult Murine Lung Causes Airspace Enlargement and Induces Inflammation

(2013) Megan P. Stogsdill et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival

(2013) A. Lau et al.   AMERICAN JOURNAL OF TRANSPLANTATION

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

(2013) Naoko Kamo et al.   HEPATOLOGY

Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular high-mobility group box 1 in cellular protection

(2013) Hai Huang et al.   HEPATOLOGY

DAMPs activating innate and adaptive immune responses in COPD

(2013) S D Pouwels et al.   Mucosal Immunology

High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers

(2013) Hsin-Kuo Ko et al.   RESPIROLOGY

Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells

(2013) Elisabetta Pace et al.   TOXICOLOGY LETTERS

RAGE signaling by alveolar macrophages influences tobacco smoke-induced inflammation

(2012) Adam B. Robinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis

(2012) Norma Maugeri et al.   AUTOIMMUNITY

RAGE: a new frontier in chronic airways disease

(2012) Maria B Sukkar et al.   BRITISH JOURNAL OF PHARMACOLOGY

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

Effect of NF-κB inhibitor on high-mobility group protein B1 expression in a COPD rat model

(2012) CHANG-MING WANG et al.   Molecular Medicine Reports

Toll-Like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease

(2012) Simona E. Budulac et al.   PLoS One

RAGE and tobacco smoke: insights into modeling chronic obstructive pulmonary disease

(2012) Adam B. Robinson et al.   Frontiers in Physiology

Effect of Five Genetic Variants Associated with Lung Function on the Risk of Chronic Obstructive Lung Disease, and Their Joint Effects on Lung Function

(2011) María Soler Artigas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cilomilast counteracts the effects of cigarette smoke in airway epithelial cells

(2011) Elisabetta Pace et al.   CELLULAR IMMUNOLOGY

Validity of HMGB1 measurement in epithelial lining fluid in patients with COPD

(2011) Hiroshi Kanazawa et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Soluble RAGE is deficient in neutrophilic asthma and COPD

(2011) M. B. Sukkar et al.   EUROPEAN RESPIRATORY JOURNAL

Introduction: HMGB1 in inflammation and innate immunity

(2011) U. Andersson et al.   JOURNAL OF INTERNAL MEDICINE

HMGB1 and Cord Blood: Its Role as Immuno-Adjuvant Factor in Innate Immunity

(2011) Alessandra Ciucci et al.   PLoS One

Long-term exposure to cigarette smoke impairs lung function and increases HMGB-1 expression in mice

(2011) Frank Silva Bezerra et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Delayed Administration of D-Ala2-D-Leu5-Enkephalin, a Delta-Opioid Receptor Agonist, Improves Survival in a Rat Model of Sepsis

(2011) Cheng Wu Tang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease

(2010) Nassima Ferhani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The T-Helper Cell Type 1 Immune Response to Gram-Negative Bacterial Infections Is Impaired in COPD

(2010) Jürgen Knobloch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Receptor for Advanced Glycation End-Products Signals through Ras during Tobacco Smoke–Induced Pulmonary Inflammation

(2010) Paul R. Reynolds et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HMGB1: Roles in base excision repair and related function

(2010) Yuan Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Danger Signaling Protein HMGB1 Induces a Distinct Form of Cell Death Accompanied by Formation of Giant Mitochondria

(2010) G. Gdynia et al.   CANCER RESEARCH

TLR4 upregulation underpins airway neutrophilia in smokers with chronic obstructive pulmonary disease and acute respiratory failure

(2010) Elisabetta Pace et al.   HUMAN IMMUNOLOGY

Association of Polymorphism in the Receptor for Advanced Glycation End Products (RAGE) Gene with Circulating RAGE Levels

(2009) Katrien H. J. Gaens et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells

(2008) Paul R. Reynolds et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY