RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD

RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke

(2019) Karl A. Sanders et al.   Scientific Reports

The receptor for advanced glycation end products is a critical mediator of type 2 cytokine signaling in the lungs

(2019) Timothy N. Perkins et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Longitudinal changes in airway hyperresponsiveness and COPD mortality

(2019) Andreas A. Teferra et al.   EUROPEAN RESPIRATORY JOURNAL

Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression

(2017) Antonino Di Stefano et al.   EUROPEAN RESPIRATORY JOURNAL

Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling

(2017) Hanbyeol Lee et al.   FASEB JOURNAL

Knockout of RAGE ameliorates mainstream cigarette smoke-induced airway inflammation in mice

(2017) Mei Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

HMGB1 translocation and release mediate cigarette smoke–induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway

(2017) Yao Cheng et al.   MOLECULAR BIOLOGY OF THE CELL

Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke

(2017) Lisa Wolf et al.   PLoS One

Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced inflammation in COPD

(2016) Simon D. Pouwels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

(2016) Simon D. Pouwels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TAK-242 attenuates acute cigarette smoke-induced pulmonary inflammation in mouse via the TLR4/NF-κB signaling pathway

(2016) Dan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome?

(2016) Ruzena Tkacova et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Contrasting roles for the receptor for advanced glycation end-products on structural cells in allergic airway inflammation vs. airway hyperresponsiveness

(2015) Akihiko Taniguchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Biomarker of Emphysema and the RAGE Axis in the Lung

(2015) John G. Yonchuk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Emphysema Requires the Receptor for Advanced Glycation End-Products Triggering on Structural Cells

(2015) Koichi Waseda et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice

(2015) Chantal Donovan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients

(2015) S. D. Pouwels et al.   EUROPEAN RESPIRATORY JOURNAL

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells

(2015) Elizabeth A. Oczypok et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Risk factors and early origins of chronic obstructive pulmonary disease

(2015) Dirkje S Postma et al.   LANCET

The Receptor for Advanced Glycation End Products (RAGE) Contributes to the Progression of Emphysema in Mice

(2015) Nisha Sambamurthy et al.   PLoS One

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

(2014) Jing Xue et al.   BIOCHEMISTRY

Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation

(2014) Md Ashik Ullah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

Conditional Overexpression of Receptors for Advanced Glycation End-Products in the Adult Murine Lung Causes Airspace Enlargement and Induces Inflammation

(2013) Megan P. Stogsdill et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evaluation of the pulmonary effects of short-term nose-only cigarette smoke exposure in mice

(2013) Abderrahim Nemmar et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

(2013) Emma L. Beckett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RAGE and TLRs: Relatives, friends or neighbours?

(2013) Zaridatul Aini Ibrahim et al.   MOLECULAR IMMUNOLOGY

DAMPs activating innate and adaptive immune responses in COPD

(2013) S D Pouwels et al.   Mucosal Immunology

Non-Essential Role for TLR2 and Its Signaling Adaptor Mal/TIRAP in Preserving Normal Lung Architecture in Mice

(2013) Saleela M. Ruwanpura et al.   PLoS One

Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice

(2013) Lisa L. Dupont et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The Receptor for Advanced Glycation End Products Is a Central Mediator of Asthma Pathogenesis

(2012) Pavle S. Milutinovic et al.   AMERICAN JOURNAL OF PATHOLOGY

Embryonic Overexpression of Receptors for Advanced Glycation End-Products by Alveolar Epithelium Induces an Imbalance between Proliferation and Apoptosis

(2012) Jeffrey A. Stogsdill et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Receptor for Advanced Glycation End Products Contributes to Postnatal Pulmonary Development and Adult Lung Maintenance Program in Mice

(2012) Silvia Fineschi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

RAGE: a new frontier in chronic airways disease

(2012) Maria B Sukkar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD

(2012) Maarten van den Berge et al.   EUROPEAN RESPIRATORY JOURNAL

Airway Epithelial Expression of TLR5 Is Downregulated in Healthy Smokers and Smokers with Chronic Obstructive Pulmonary Disease

(2012) R. Wang et al.   JOURNAL OF IMMUNOLOGY

Up-Regulation of Receptors for Advanced Glycation End-Products by Alveolar Epithelium Influences Cytodifferentiation and Causes Severe Lung Hypoplasia

(2011) Paul R. Reynolds et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease

(2011) Patrick Geraghty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced glycation end products enhance reactive oxygen and nitrogen species generation in neutrophils in vitro

(2011) Savita Bansal et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

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(2011) Changchun Hou et al.   MOLECULAR MEDICINE

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

(2011) Masakiyo Sakaguchi et al.   PLoS One

Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease

(2010) Nassima Ferhani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-δ: implications for vascular disease

(2009) Weijing Cai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Toll/IL-1 Signaling Is Critical for House Dust Mite–specific Th1 and Th2 Responses

(2009) Simon Phipps et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

HMGB1 Enhances the Proinflammatory Activity of Lipopolysaccharide by Promoting the Phosphorylation of MAPK p38 through Receptor for Advanced Glycation End Products

(2009) Y.-H. Qin et al.   JOURNAL OF IMMUNOLOGY