Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox

Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression

(2017) Antonino Di Stefano et al.   EUROPEAN RESPIRATORY JOURNAL

The Contribution of Small Airway Obstruction to the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2017) James C. Hogg et al.   PHYSIOLOGICAL REVIEWS

Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD

(2017) Mathew S. Eapen et al.   RESPIROLOGY

Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema

(2016) Rosa Faner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dysregulation of Antiviral Function of CD8+T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1–PD-L1 Axis

(2016) Richard T. McKendry et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-1α: a key player for epithelial-to-mesenchymal signalling in COPD?

(2016) Antoine Froidure et al.   EUROPEAN RESPIRATORY JOURNAL

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD

(2016) Emmanuel T. Osei et al.   EUROPEAN RESPIRATORY JOURNAL

Corticosteroid modulation of immunoglobulin expression and B-cell function in COPD

(2016) Jin Lee et al.   FASEB JOURNAL

Transforming growth factor (TGF) β1 and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis

(2016) Malik Q. Mahmood et al.   RESPIROLOGY

B Cell–Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease

(2015) Francesca Polverino et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disruption of Th17/Treg Balance in the Sputum of Patients With Chronic Obstructive Pulmonary Disease

(2015) Haijun Li et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition

(2015) Sophie T. Gohy et al.   EUROPEAN RESPIRATORY JOURNAL

A Critical Role for Dendritic Cells in the Evolution of IL-1β–Mediated Murine Airway Disease

(2015) Mitsuo Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in COPD and neutrophilic asthma

(2015) Richard Y Kim et al.   THORAX

Molecular Regulation of Toll-like Receptors in Asthma and COPD

(2015) Li Zuo et al.   Frontiers in Physiology

Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction

(2015) Malik Mahmood et al.   International Journal of Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer: Epithelial Mesenchymal Transition (EMT), the Missing Link?

(2015) Sukhwinder Singh Sohal   EBioMedicine

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

(2014) Li Zuo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Airway Basal Cells. The “Smoking Gun” of Chronic Obstructive Pulmonary Disease

(2014) Ronald G. Crystal   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease

(2014) Huaying Wang et al.   Clinical Respiratory Journal

Eosinophilic inflammation in COPD: prevalence and clinical characteristics: Table 1–

(2014) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Overexpression of CD163, CD204 and CD206 on Alveolar Macrophages in the Lungs of Patients with Severe Chronic Obstructive Pulmonary Disease

(2014) Yoichiro Kaku et al.   PLoS One

Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent

(2014) Christine M. Freeman et al.   PLoS One

Human CD56+ Cytotoxic Lung Lymphocytes Kill Autologous Lung Cells in Chronic Obstructive Pulmonary Disease

(2014) Christine M. Freeman et al.   PLoS One

Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD

(2014) Javier Milara et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD

(2014) Antonino Di Stefano et al.   THORAX

A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial–mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study

(2014) Sukhwinder Singh Sohal et al.   International Journal of Chronic Obstructive Pulmonary Disease

Distribution of T-Cell Subsets in BAL Fluid of Patients With Mild to Moderate COPD Depends on Current Smoking Status and Not Airway Obstruction

(2013) Helena Forsslund et al.   CHEST

Respiratory Viral Detection and Small Airway Inflammation in Lung Tissue of Patients with Stable, Mild COPD

(2013) Soraya Utokaparch et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Expression of Interleukin (IL)-10, IL-17A and IL-22 in Serum and Sputum of Stable Chronic Obstructive Pulmonary Disease Patients

(2013) Li Zhang et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

The danger signal plus DNA damage two-hit hypothesis for chronic inflammation in COPD

(2013) Kazutetsu Aoshiba et al.   EUROPEAN RESPIRATORY JOURNAL

Innate Immunity and Chronic Obstructive Pulmonary Disease: A Mini-Review

(2013) Renat Shaykhiev et al.   GERONTOLOGY

Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease: A Retrospective Study

(2013) Ersin Günay et al.   INFLAMMATION

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

(2013) Emma L. Beckett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Changes in Airway Histone Deacetylase2 in Smokers and COPD with Inhaled Corticosteroids: A Randomized Controlled Trial

(2013) Sukhwinder Singh Sohal et al.   PLoS One

Down Regulation of T Cell Receptor Expression in COPD Pulmonary CD8 Cells

(2013) Seamus Grundy et al.   PLoS One

Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

(2013) Christine M Freeman et al.   RESPIRATORY RESEARCH

The role of uPAR in epithelial-mesenchymal transition in small airway epithelium of patients with chronic obstructive pulmonary disease

(2013) Qin Wang et al.   RESPIRATORY RESEARCH

Myofibroblast expression in airways and alveoli is affected by smoking and COPD

(2013) Henna M Karvonen et al.   RESPIRATORY RESEARCH

Imbalance between subpopulations of regulatory T cells in COPD

(2013) Jia Hou et al.   THORAX

Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke

(2013) Javier Milara et al.   THORAX

Differential expression of pro-inflammatory cytokines in intra-epithelial T cells between trachea and bronchi distinguishes severity of COPD

(2012) Greg Hodge et al.   CYTOKINE

Increased intraepithelial (CD103+) CD8+ T cells in the airways of smokers with and without chronic obstructive pulmonary disease

(2012) M. Mikko et al.   IMMUNOBIOLOGY

Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients

(2012) Oskar Hallgren et al.   Journal of Translational Medicine

Distribution of γδ and other T-lymphocyte subsets in patients with chronic obstructive pulmonary disease and asthma

(2012) Daiva Urboniene et al.   RESPIRATORY MEDICINE

The association of down-regulated toll-like receptor 4 expression with airflow limitation and emphysema in smokers

(2012) Sei Won Lee et al.   RESPIRATORY RESEARCH

IL-17 in chronic obstructive pulmonary disease

(2012) Mario Cazzola et al.   Expert Review of Respiratory Medicine

Behavioral and Structural Differences in Migrating Peripheral Neutrophils from Patients with Chronic Obstructive Pulmonary Disease

(2011) Elizabeth Sapey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of increased CD8/CD28null T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease

(2011) G. Hodge et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Airway Clearance of Apoptotic Cells in COPD

(2011) Violet R.S. Mukaro et al.   CURRENT DRUG TARGETS

Mast cells in COPD airways: relationship to bronchodilator responsiveness and angiogenesis

(2011) Amir Soltani et al.   EUROPEAN RESPIRATORY JOURNAL

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

(2011) C.A. Ambarus et al.   JOURNAL OF IMMUNOLOGICAL METHODS

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β1 Is Increased in Chronic Obstructive Pulmonary Disease

(2011) Hoeke A. Baarsma et al.   PLoS One

Patterns of Inflammatory Responses in Large and Small Airways in Smokers with and without Chronic Obstructive Pulmonary Disease

(2011) Sergejs Isajevs et al.   RESPIRATION

Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease

(2011) María Inés Vargas-Rojas et al.   RESPIRATORY MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo

(2010) Renat Shaykhiev et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

COPD Is Associated With a Macrophage Scavenger Receptor-1 Gene Sequence Variation

(2010) Jill A. Ohar et al.   CHEST

Cytotoxic Potential of Lung CD8+ T Cells Increases with Chronic Obstructive Pulmonary Disease Severity and with In Vitro Stimulation by IL-18 or IL-15

(2010) C. M. Freeman et al.   JOURNAL OF IMMUNOLOGY

Differential lymphocyte infiltration in small airways and lung parenchyma in COPD patients

(2010) Jordi Olloquequi et al.   RESPIRATORY MEDICINE

Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease

(2010) Sukhwinder S. SOHAL et al.   RESPIROLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Animal models of cigarette smoke-induced chronic obstructive pulmonary disease

(2010) Joanne L Wright et al.   Expert Review of Respiratory Medicine

Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products

(2009) Mirella Profita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alterations in Lung Mast Cell Populations in Patients with Chronic Obstructive Pulmonary Disease

(2009) Cecilia K. Andersson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Decreased Small Airway and Alveolar CD83+ Dendritic Cells in COPD

(2009) Maria Tsoumakidou et al.   CHEST

T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients

(2009) A. Di Stefano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Decreased Sputum Mature Dendritic Cells in Healthy Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2009) Maria Tsoumakidou et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease

(2009) R. Shaykhiev et al.   JOURNAL OF IMMUNOLOGY

Increased intraepithelial T-cells in stable COPD

(2008) Magnus J. Löfdahl et al.   RESPIRATORY MEDICINE

Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking

(2007) B. Barcelo et al.   EUROPEAN RESPIRATORY JOURNAL