The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Targeting the TLR signalosome with TIR domain-derived cell-permeable decoy peptides: the current state and perspectives

(2020) Vladimir Y Toshchakov et al.   Innate Immunity

Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model

(2019) Juliana Tiyaki Ito et al.   PLoS One

Effect of Bufei Yishen Granules Combined with Electroacupuncture in Rats with Chronic Obstructive Pulmonary Disease via the Regulation of TLR-4/NF-κB Signaling

(2019) Jindi Ma et al.   Evidence-based Complementary and Alternative Medicine

The monocyte-dependent immune response to bacteria is suppressed in smoking-induced COPD

(2019) Jürgen Knobloch et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tolerogenic signalling of alveolar macrophages induces lung adaptation to oxidative injury

(2019) Benoit Allard et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of Toll-Like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on TLR4 Signaling

(2019) Shofiul Azam et al.   Frontiers in Immunology

Th1/17-Biased Inflammatory Environment Associated with COPD Alters the Response of Airway Epithelial Cells to Viral and Bacterial Stimuli

(2019) Yifan Chen et al.   MEDIATORS OF INFLAMMATION

Toll-Like Receptors and Relevant Emerging Therapeutics with Reference to Delivery Methods

(2019) Javaid et al.   Pharmaceutics

Functional variations of the TLR4 gene in association with chronic obstructive pulmonary disease and pulmonary tuberculosis

(2019) Zhongqi Li et al.   BMC Pulmonary Medicine

FOXO3a regulates rhinovirus-induced innate immune responses in airway epithelial cells

(2019) Joao Gimenes-Junior et al.   Scientific Reports

MyD88 as a therapeutic target for inflammatory lung diseases

(2018) Franco Di Padova et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cyclodextrins: structure, physicochemical properties and pharmaceutical applications

(2018) Phatsawee Jansook et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ulinastatin protects the lungs of COPD rats through the HMGB1/TLR4 signaling pathway

(2018) Wei Liu et al.   Oncology Letters

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

(2018) Simon Lea et al.   International Journal of Chronic Obstructive Pulmonary Disease

The immune system as a victim and aggressor in chronic obstructive pulmonary disease

(2018) Joshua J. C. McGrath et al.   Journal of Thoracic Disease

Pro-inflammatory effects of extracellular Hsp70 and cigarette smoke in primary airway epithelial cells from COPD patients

(2018) Andrea Hulina-Tomašković et al.   BIOCHIMIE

Recent clinical trends in Toll-like receptor targeting therapeutics

(2018) Muhammad Ayaz Anwar et al.   MEDICINAL RESEARCH REVIEWS

Toll-like receptors in COPD

(2017) Philip M. Hansbro et al.   EUROPEAN RESPIRATORY JOURNAL

Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression

(2017) Antonino Di Stefano et al.   EUROPEAN RESPIRATORY JOURNAL

Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke

(2017) Gimano D. Amatngalim et al.   Journal of Innate Immunity

Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics

(2017) Wei Gao et al.   Frontiers in Physiology

TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver Failure

(2017) Chunli Xu et al.   Frontiers in Immunology

A systemic defect in Toll-like receptor 4 signaling increases lipopolysaccharide-induced suppression of IL-2-dependent T-cell proliferation in COPD

(2016) Jürgen Knobloch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sulforaphane Suppressed LPS and Pam3CSK4 Mediated Inflammation in COPD Through MyD88-Dependent Toll-Like Receptors Pathway

(2016) Xiaoli Zeng et al.   CHEST

Th17 regulating lower airway disease

(2016) Lorenzo Cosmi et al.   Current Opinion in Allergy and Clinical Immunology

Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes

(2016) Amanda Croasdell et al.   FASEB JOURNAL

Association between TLR2/TLR4 gene polymorphisms and COPD phenotype in a Greek cohort

(2016) A. Apostolou et al.   HERZ

Biomass smoke as a risk factor for chronic obstructive pulmonary disease: effects on innate immunity

(2016) Jordi Olloquequi et al.   Innate Immunity

Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways

(2016) Anjali Roy et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bacterial–viral load and the immune response in stable and exacerbated COPD: significance and therapeutic prospects

(2016) Silvestro D'Anna et al.   International Journal of Chronic Obstructive Pulmonary Disease

Effects of budesonide on toll-like receptor expression in alveolar macrophages from smokers with and without COPD

(2016) Jie Ji et al.   International Journal of Chronic Obstructive Pulmonary Disease

COPD disease severity and innate immune response to pathogen-associated molecular patterns

(2016) Vincent Fan et al.   International Journal of Chronic Obstructive Pulmonary Disease

Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants

(2016) Anna Pomerenke et al.   International Journal of Chronic Obstructive Pulmonary Disease

Disruption of Th17/Treg Balance in the Sputum of Patients With Chronic Obstructive Pulmonary Disease

(2015) Haijun Li et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Synthetic Nanoparticles for Vaccines and Immunotherapy

(2015) Darrell J. Irvine et al.   CHEMICAL REVIEWS

Toll-like receptors: Activation, signalling and transcriptional modulation

(2015) Dominic De Nardo   CYTOKINE

TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis

(2015) Mukanthu H. Nyirenda et al.   JOURNAL OF IMMUNOLOGY

Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain

(2015) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Budesonide increases TLR4 and TLR2 expression in Treg lymphocytes of allergic asthmatics

(2015) Elisabetta Pace et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Molecular Regulation of Toll-like Receptors in Asthma and COPD

(2015) Li Zuo et al.   Frontiers in Physiology

Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages

(2014) H. J. Metcalfe et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease

(2014) Huaying Wang et al.   Clinical Respiratory Journal

Impaired innate immune alveolar macrophage response and the predilection for COPD exacerbations

(2014) Charles S Berenson et al.   THORAX

Source of Biomass Cooking Fuel Determines Pulmonary Response to Household Air Pollution

(2013) Thomas E. Sussan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TLR4 Up-regulation and Reduced Foxp3 Expression in Mechanically Ventilated Smokers with Obstructive Chronic Bronchitis

(2013) Elisabetta Pace et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

(2013) Kurt Lucas et al.   MOLECULAR NEUROBIOLOGY

Dendrimer as nanocarrier for drug delivery

(2013) Prashant Kesharwani et al.   PROGRESS IN POLYMER SCIENCE

Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

(2013) Christine M Freeman et al.   RESPIRATORY RESEARCH

Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals

(2013) Alexandra Zanin-Zhorov et al.   Frontiers in Immunology

Magnetic Hydrogels and Their Potential Biomedical Applications

(2012) Yuhui Li et al.   ADVANCED FUNCTIONAL MATERIALS

TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema

(2012) Chang Hyeok An et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IFN-γ synergistically enhances LPS signalling in alveolar macrophages from COPD patients and controls by corticosteroid-resistant STAT1 activation

(2012) T Southworth et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Effects of TLR Activation on T-Cell Development and Differentiation

(2012) Bo Jin et al.   Clinical & Developmental Immunology

Toll-Like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease

(2012) Simona E. Budulac et al.   PLoS One

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

(2012) J. M. Reynolds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The association of down-regulated toll-like receptor 4 expression with airflow limitation and emphysema in smokers

(2012) Sei Won Lee et al.   RESPIRATORY RESEARCH

Resveratrol Impairs the Release of Steroid-resistant Cytokines from Bacterial Endotoxin-Exposed Alveolar Macrophages in Chronic Obstructive Pulmonary Disease

(2011) Jürgen Knobloch et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Fully reversible pulmonary arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia

(2011) D. Dumitrescu et al.   EUROPEAN RESPIRATORY JOURNAL

Liposomal vaccine delivery systems

(2011) Malou Henriksen-Lacey et al.   Expert Opinion on Drug Delivery

Effects of air pollutants on innate immunity: The role of Toll-like receptors and nucleotide-binding oligomerization domain–like receptors

(2011) Rebecca N. Bauer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR2 Stimulation Drives Human Naive and Effector Regulatory T Cells into a Th17-Like Phenotype with Reduced Suppressive Function

(2011) M. H. Nyirenda et al.   JOURNAL OF IMMUNOLOGY

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Innate Immune Responses Are Increased in Chronic Obstructive Pulmonary Disease

(2011) Katherine Joanne Baines et al.   PLoS One

Toll-like receptor expression in smokers with and without COPD

(2011) Ida von Scheele et al.   RESPIRATORY MEDICINE

The T-Helper Cell Type 1 Immune Response to Gram-Negative Bacterial Infections Is Impaired in COPD

(2010) Jürgen Knobloch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

(2010) Joseph M. Reynolds et al.   IMMUNITY

Budesonide enhances Toll-like receptor 2 expression in activated bronchial epithelial cells

(2010) Ida von Scheele et al.   INHALATION TOXICOLOGY

Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor

(2009) E. Mortaz et al.   EUROPEAN RESPIRATORY JOURNAL

The contribution of direct TLR signaling to T cell responses

(2009) Adeeb H. Rahman et al.   IMMUNOLOGIC RESEARCH

Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter

(2009) Joanna Shoenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells

(2008) Elisabetta Pace et al.   IMMUNOLOGY