Gut Microbiota-Derived Short-Chain Fatty Acids: Impact on Cancer Treatment Response and Toxicities

Cancer Therapy-Induced Cardiotoxicity—A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy

(2022) Anurag Choksey et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages

(2022) Yaxin Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction

(2022) Xi Yue et al.   BMC IMMUNOLOGY

Comparison of synbiotics combined with enteral nutrition and prophylactic antibiotics as supportive care in patients with esophageal cancer undergoing neoadjuvant chemotherapy: A multicenter randomized study

(2022) Masaaki Motoori et al.   CLINICAL NUTRITION

Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

(2022) Nazli Dizman et al.   NATURE MEDICINE

Dual contribution of the gut microbiome to immunotherapy efficacy and toxicity: supportive care implications and recommendations

(2022) Hannah R. Wardill et al.   SUPPORTIVE CARE IN CANCER

Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors

(2022) Yusuke Tomita et al.   OncoImmunology

Metagenomic Analyses Reveal Distinct Gut Microbiota Signature for Predicting the Neoadjuvant Chemotherapy Responsiveness in Breast Cancer Patients

(2022) Yuanyuan Li et al.   Frontiers in Oncology

Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models

(2022) Concetta Panebianco et al.   BIOMEDICINE & PHARMACOTHERAPY

Cancer immunotherapy resistance: The impact of microbiome-derived short-chain fatty acids and other emerging metabolites

(2022) Fatema Hersi et al.   LIFE SCIENCES

Microbial short-chain fatty acids: a strategy to tune adoptive T cell therapy

(2022) Priya Rangan et al.   Journal for ImmunoTherapy of Cancer

Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction

(2022) C. Cristiano et al.   BIOMEDICINE & PHARMACOTHERAPY

Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation

(2021) Kaiting Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay

(2021) Li Wu et al.   Nutrients

Microbial Regulation of Host Physiology by Short-chain Fatty Acids

(2021) Bart van der Hee et al.   TRENDS IN MICROBIOLOGY

Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis

(2021) Stephanie Trend et al.   Scientific Reports

Probiotics in Cancer

(2021) Ke Lu et al.   Frontiers in Oncology

Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation

(2021) Travis T. Sims et al.   Communications Biology

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

(2021) Yao He et al.   Cell Metabolism

Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

(2021) Sara Deleu et al.   EBioMedicine

Butyrate Suppresses Glucose Metabolism of Colorectal Cancer Cells via GPR109a-AKT Signaling Pathway and Enhances Chemotherapy

(2021) Hong-Wei Geng et al.   Frontiers in Molecular Biosciences

Role of microbiota-derived short-chain fatty acids in cancer development and prevention

(2021) Rasoul Mirzaei et al.   BIOMEDICINE & PHARMACOTHERAPY

The gut microbiome: what the oncologist ought to know

(2021) K. A. Lee et al.   BRITISH JOURNAL OF CANCER

Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis

(2021) Muthu Thiruvengadam et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Relationships of Gut Microbiota Composition, Short-Chain Fatty Acids and Polyamines with the Pathological Response to Neoadjuvant Radiochemotherapy in Colorectal Cancer Patients

(2021) Lidia Sánchez-Alcoholado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Pelvic Radiation Therapy for Prostate Cancer on Global Metabolic Profiles and Microbiota-Driven Gastrointestinal Late Side Effects: A Longitudinal Observational Study

(2021) Miguel R. Ferreira et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Fecal Short-Chain Fatty Acid Ratios as Related to Gastrointestinal and Depressive Symptoms in Young Adults

(2021) Bettina Müller et al.   PSYCHOSOMATIC MEDICINE

Microbial metabolites: novel therapeutic tools for boosting cancer therapies

(2021) Maik Luu et al.   TRENDS IN CELL BIOLOGY

Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

(2021) Maik Luu et al.   Nature Communications

Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury

(2021) Yangyang Li et al.   Frontiers in Cellular and Infection Microbiology

Combining Sodium Butyrate With Cisplatin Increases the Apoptosis of Gastric Cancer In Vivo and In Vitro via the Mitochondrial Apoptosis Pathway

(2021) Yangbo Li et al.   Frontiers in Pharmacology

Ultrafine Jujube Powder Enhances the Infiltration of Immune Cells during Anti-PD-L1 Treatment against Murine Colon Adenocarcinoma

(2021) Nan Jing et al.   Cancers

Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

(2021) Kai Han et al.   Nature Biomedical Engineering

Adverse Effects of Total Body Irradiation: A Two-Decade, Single Institution Analysis

(2021) Richard Pearlman et al.   Advances in Radiation Oncology

Gut Microbiota-Derived l-Histidine/Imidazole Propionate Axis Fights against the Radiation-Induced Cardiopulmonary Injury

(2021) Zhiyuan Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

(2021) Christine N. Spencer et al.   SCIENCE

Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer’s Disease Transgenic Mouse Model at an Early Disease Stage

(2020) W.M.A.D. Binosha Fernando et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment

(2020) Andrea Botticelli et al.   Journal of Translational Medicine

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

(2020) Ygor Parladore Silva et al.   Frontiers in Endocrinology

Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro

(2020) Woan Ting Tay et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

(2020) Clélia Coutzac et al.   Nature Communications

The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

(2020) Kate A. Markey et al.   BLOOD

Association of Probiotic Clostridium butyricum Therapy with Survival and Response to Immune Checkpoint Blockade in Patients with Lung Cancer

(2020) Yusuke Tomita et al.   Cancer Immunology Research

Comparison of Hematologic Toxicity and Bone Marrow Compensatory Response in Head and Neck vs. Cervical Cancer Patients Undergoing Chemoradiotherapy

(2020) Lucas K. Vitzthum et al.   Frontiers in Oncology

Association of Short-Chain Fatty Acids in the Gut Microbiome With Clinical Response to Treatment With Nivolumab or Pembrolizumab in Patients With Solid Cancer Tumors

(2020) Motoo Nomura et al.   JAMA Network Open

Functional and phylogenetic alterations in gut microbiome are linked to graft-versus-host disease severity

(2020) Mathilde Payen et al.   Blood Advances

Factors associated with sleep quality during chemotherapy: An integrative review

(2020) Regina Claudia da Silva Souza et al.   Nursing Open

Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation

(2020) Chee Kin Then et al.   BMC BIOLOGY

The microbiota-gut-brain axis: An emerging therapeutic target in chemotherapy-induced cognitive impairment

(2020) Courtney B. Subramaniam et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Sodium Butyrate Combined with Docetaxel for the Treatment of Lung Adenocarcinoma A549 Cells by Targeting Gli1

(2020) Maojian Chen et al.   OncoTargets and Therapy

Effects of dietary fibre intake in chemotherapy-induced mucositis in murine model

(2020) B. Gallotti et al.   BRITISH JOURNAL OF NUTRITION

Gut Microbiome Components Predict Response to Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Prospective, Longitudinal Study

(2020) Yuxi Yi et al.   CLINICAL CANCER RESEARCH

Delivery of Acetate to the Peripheral Blood after Consumption of Foods High in Short‐Chain Fatty Acids

(2020) Paul A. Gill et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Glabridin Prevents Doxorubicin-Induced Cardiotoxicity Through Gut Microbiota Modulation and Colonic Macrophage Polarization in Mice

(2019) Keqing Huang et al.   Frontiers in Pharmacology

The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity

(2019) Michele Russo et al.   EUROPEAN JOURNAL OF HEART FAILURE

Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivors

(2019) Ryo Okubo et al.   BRAIN BEHAVIOR AND IMMUNITY

Adjunctive fecal microbiota transplantation in supportive oncology: Emerging indications and considerations in immunocompromised patients

(2019) H.R. Wardill et al.   EBioMedicine

Fecal Microbiome, Metabolites, and Stem Cell Transplant Outcomes: A Single-Center Pilot Study

(2019) Jessica R Galloway-Peña et al.   Open Forum Infectious Diseases

Review of Graft-Versus-Host Disease

(2019) Vignesh Ramachandran et al.   DERMATOLOGIC CLINICS

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

Cardiotoxicity with immune system targeting drugs: a meta-analysis of anti-PD/PD-L1 immunotherapy randomized clinical trials

(2019) Mohamed Rahouma et al.   Immunotherapy

The pathogenesis of mucositis: updated perspectives and emerging targets

(2019) J. Bowen et al.   SUPPORTIVE CARE IN CANCER

Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines

(2019) Joanne M. Bowen et al.   SUPPORTIVE CARE IN CANCER

Effects of hippocampal histone acetylation and HDAC inhibition on spatial learning and memory in the Morris water maze in rats

(2019) Ruhan Deniz Topuz et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response

(2019) Mireia Uribe-Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanotechnology intervention of the microbiome for cancer therapy

(2019) Wantong Song et al.   Nature Nanotechnology

Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

(2018) P. A. Gill et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications.

(2018) Sara Daniela Gomes et al.   CURRENT MEDICINAL CHEMISTRY

Management of Radiation Proctitis

(2018) Lameese Tabaja et al.   DIGESTIVE DISEASES AND SCIENCES

Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells

(2018) João Crispim Encarnação et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Carboxymethyl pachyman (CMP) reduces intestinal mucositis and regulates the intestinal microflora in 5-fluorouracil-treated CT26 tumour-bearing mice

(2018) Canhong Wang et al.   Food & Function

Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy

(2018) Alexandra C. Apple et al.   NeuroImage-Clinical

Neuroimmunology of Behavioral Comorbidities Associated With Cancer and Cancer Treatments

(2018) Jessica C. Santos et al.   Frontiers in Immunology

Antibiotic Exposure and Reduced Short Chain Fatty Acid Production after Hematopoietic Stem Cell Transplant

(2018) Lindsey E. Romick-Rosendale et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Microbial metabolite sensor GPR43 controls severity of experimental GVHD

(2018) Hideaki Fujiwara et al.   Nature Communications

A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells

(2018) Mamiko Kobayashi et al.   Oncotarget

Short-Chain Fatty Acids Inhibit Oxidative Stress and Inflammation in Mesangial Cells Induced by High Glucose and Lipopolysaccharide

(2017) Wei Huang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Reactivity toward Bifidobacterium longum and Enterococcus hirae demonstrate robust CD8 + T cell response and better prognosis in HBV-related hepatocellular carcinoma

(2017) Yihui Rong et al.   EXPERIMENTAL CELL RESEARCH

The relationship between cancer patient's fear of recurrence and chemotherapy: A systematic review and meta-analysis

(2017) Yuan Yang et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Moving beyond microbiome-wide associations to causal microbe identification

(2017) Neeraj K. Surana et al.   NATURE

Gut microbiota modulation of chemotherapy efficacy and toxicity

(2017) James L. Alexander et al.   Nature Reviews Gastroenterology & Hepatology

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiota composition associated with alterations in cardiorespiratory fitness and psychosocial outcomes among breast cancer survivors

(2017) Jesseca A. Paulsen et al.   SUPPORTIVE CARE IN CANCER

Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns

(2017) Alexandra C. Apple et al.   NeuroImage-Clinical

Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients

(2017) Arthur E. Frankel et al.   NEOPLASIA

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

The acute effects of inulin and resistant starch on postprandial serum short-chain fatty acids and second-meal glycemic response in lean and overweight humans

(2016) S Rahat-Rozenbloom et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective

(2016) Peter Schönfeld et al.   JOURNAL OF LIPID RESEARCH

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

(2016) Eef Boets et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

HDACs and HDAC Inhibitors in Cancer Development and Therapy

(2016) Yixuan Li et al.   Cold Spring Harbor Perspectives in Medicine

Gut microbiota trajectory in pediatric patients undergoing hematopoietic SCT

(2015) E Biagi et al.   BONE MARROW TRANSPLANTATION

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Daily Sodium Butyrate Enema for the Prevention of Radiation Proctitis in Prostate Cancer Patients Undergoing Radical Radiation Therapy: Results of a Multicenter Randomized Placebo-Controlled Dose-Finding Phase 2 Study

(2014) Angelo Maggio et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

A Perspective on the Complexity of Dietary Fiber Structures and Their Potential Effect on the Gut Microbiota

(2014) Bruce R. Hamaker et al.   JOURNAL OF MOLECULAR BIOLOGY

Epigenetic Enhancement of Brain-Derived Neurotrophic Factor Signaling Pathway Improves Cognitive Impairments Induced by Isoflurane Exposure in Aged Rats

(2014) MuHuo Ji et al.   MOLECULAR NEUROBIOLOGY

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

(2014) Tomáš Šimůnek et al.   Pharmacological Reports

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Effects of Sodium Butyrate and Its Synthetic Amide Derivative on Liver Inflammation and Glucose Tolerance in an Animal Model of Steatosis Induced by High Fat Diet

(2013) Giuseppina Mattace Raso et al.   PLoS One

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells

(2012) Mary A. Zimmerman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oral Supplementation of Butyrate Reduces Mucositis and Intestinal Permeability Associated with 5-Fluorouracil Administration

(2012) Talita Mayra Ferreira et al.   LIPIDS

Prefrontal Cortex and Executive Function Impairments in Primary Breast Cancer

(2011) Shelli R. Kesler   ARCHIVES OF NEUROLOGY

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Propionate as a health-promoting microbial metabolite in the human gut

(2011) Elham Hosseini et al.   NUTRITION REVIEWS

Effects of a histone deacetylase inhibitor, sodium butyrate, on 53-kDa protein expression and sensitivity to anticancer drugs of pancreatic cancer cells

(2010) Masaki Kitazono et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Regimen-related gastrointestinal toxicities in cancer patients

(2010) Stephen T Sonis   Current Opinion in Supportive and Palliative Care

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Sodium butyrate enemas in the treatment of acute radiation-induced proctitis in patients with prostate cancer and the impact on late proctitis

(2008) Andrea Hille et al.   STRAHLENTHERAPIE UND ONKOLOGIE