γ-Glutamylcysteine Exerts Neuroprotection Effects against Cerebral Ischemia/Reperfusion Injury through Inhibiting Lipid Peroxidation and Ferroptosis

COX-2/PGE2 Pathway Inhibits the Ferroptosis Induced by Cerebral Ischemia Reperfusion

(2022) Yunfei Xu et al.   MOLECULAR NEUROBIOLOGY

Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy

(2021) Xing Li et al.   Science Advances

Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats

(2021) Huihui Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

Nrf2/Keap1/ARE signaling: Towards specific regulation

(2021) Alexey V. Ulasov et al.   LIFE SCIENCES

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Protective Effects and Mechanisms of Action of Ulinastatin against Cerebral Ischemia–Reperfusion Injury

(2020) Bing Lv et al.   CURRENT PHARMACEUTICAL DESIGN

Protective Effect of Stachydrine Against Cerebral Ischemia-Reperfusion Injury by Reducing Inflammation and Apoptosis Through P65 and JAK2/STAT3 Signaling Pathway

(2020) Li Li et al.   Frontiers in Pharmacology

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

(2020) Yingchuan Li et al.   CELL DEATH AND DIFFERENTIATION

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway

(2020) Jisun Lim et al.   Science Advances

Stroke

(2020) Bruce C V Campbell et al.   LANCET

Neuroprotection of Intermedin Against Cerebral Ischemia/Reperfusion Injury Through Cerebral Microcirculation Improvement and Apoptosis Inhibition

(2020) Xin Guo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury

(2020) Sicheng Tang et al.   Frontiers in Cellular Neuroscience

Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity

(2020) Yu Zheng et al.   NEURAL PLASTICITY

Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway

(2020) Jin Du et al.   Aging-US

Critical Role of Nrf2 in Experimental Ischemic Stroke

(2019) Lei Liu et al.   Frontiers in Pharmacology

Liraglutide and its Neuroprotective Properties—Focus on Possible Biochemical Mechanisms in Alzheimer’s Disease and Cerebral Ischemic Events

(2019) Michał Wiciński et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis and Brain Injury

(2019) Leslie Magtanong et al.   DEVELOPMENTAL NEUROSCIENCE

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Stroke in China: advances and challenges in epidemiology, prevention, and management

(2019) Simiao Wu et al.   LANCET NEUROLOGY

Doenjang, A Korean Traditional Fermented Soybean Paste, Ameliorates Neuroinflammation and Neurodegeneration in Mice Fed a High-Fat Diet

(2019) Je Won Ko et al.   Nutrients

Photothermal-Enhanced Inactivation of Glutathione Peroxidase for Ferroptosis Sensitized by an Autophagy Promotor

(2019) Peijing An et al.   ACS Applied Materials & Interfaces

Functional Characterization of the Grapevine γ-Glutamyl Transferase/Transpeptidase (E.C. 2.3.2.2) Gene Family Reveals a Single Functional Gene Whose Encoded Protein Product Is Not Located in Either the Vacuole or Apoplast

(2019) Joshua G. Philips et al.   Frontiers in Plant Science

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation

(2019) Jin-Hui Liu et al.   EXPERIMENTAL NEUROLOGY

The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury: a literature review

(2019) Zili Feng et al.   MOLECULAR MEDICINE

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

(2018) Ming-Shuo Sun et al.   Oxidative Medicine and Cellular Longevity

Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice

(2018) Pu Hong et al.   NEURAL PLASTICITY

Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats

(2018) Devin W. McBride et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells

(2018) Chuanhong Wu et al.   Scientific Reports

γ-Glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level

(2018) Yang Yang et al.   Redox Biology

Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome

(2017) Elizabeth Nance et al.   Journal of Neuroinflammation

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death

(2016) Yuan Fang et al.   Scientific Reports

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

(2015) Ian F. Kimbrough et al.   BRAIN

Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement

(2015) Ali Alawieh et al.   Journal of Neuroinflammation

Increase in the Protein-Bound Form of Glutathione in Human Blood after the Oral Administration of Glutathione

(2014) Eun Young Park et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fucoxanthin Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes

(2014) Jian Zheng et al.   Marine Drugs

ALDH2 protects against stroke by clearing 4-HNE

(2013) Jin-Min Guo et al.   CELL RESEARCH

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke

(2013) Zhenjun Tan et al.   STROKE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats

(2012) Chao Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion

(2012) Isaac García-Yébenes et al.   NEUROCHEMISTRY INTERNATIONAL

Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research

(2012) C. Kilkenny et al.   OSTEOARTHRITIS AND CARTILAGE

γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor

(2012) Ruben Quintana-Cabrera et al.   Nature Communications

Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers

(2011) Jason Allen et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Rhinacanthus nasutus Protects Cultured Neuronal Cells against Hypoxia Induced Cell Death

(2011) James M. Brimson et al.   MOLECULES

Prodrug Approach for Increasing Cellular Glutathione Levels

(2010) Ivana Cacciatore et al.   MOLECULES

γ-Glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo

(2010) Truc M. Le et al.   NEUROTOXICOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH