OATD-02 Validates the Benefits of Pharmacological Inhibition of Arginase 1 and 2 in Cancer

Microenvironmental influences on T cell immunity in cancer and inflammation

(2022) Darren R. Heintzman et al.   Cellular & Molecular Immunology

Arginase: An emerging and promising therapeutic target for cancer treatment

(2022) Fanglin Niu et al.   BIOMEDICINE & PHARMACOTHERAPY

Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study

(2022) Aung Naing et al.   Journal for ImmunoTherapy of Cancer

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

(2021) Jennifer K. Dowling et al.   Nature Communications

The footprint of kynurenine pathway in every cancer: a new target for chemotherapy

(2021) Moein Ala   EUROPEAN JOURNAL OF PHARMACOLOGY

Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis

(2021) Yanfei Jiang et al.   MOLECULAR BIOLOGY REPORTS

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology

(2021) Min Lu et al.   ACS Medicinal Chemistry Letters

Arginine Signaling and Cancer Metabolism

(2021) Chia-Lin Chen et al.   Cancers

A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment

(2021) Paulina Pilanc et al.   Frontiers in Oncology

The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer

(2021) Alexandra Giatromanolaki et al.   Cancer & Metabolism

Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression

(2021) Andreia Matos et al.   Nutrients

Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells

(2021) Tomasz M. Grzywa et al.   Communications Biology

Amino acids in cancer

(2020) Elizabeth L. Lieu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Phase 1 Study of Epacadostat in Combination With Atezolizumab for Patients With Previously Treated Advanced Non‐Small Cell Lung Cancer

(2020) Matthew D. Hellmann et al.   INTERNATIONAL JOURNAL OF CANCER

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling

(2020) Yi Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors

(2020) Roman Blaszczyk et al.   ACS Medicinal Chemistry Letters

Myeloid Cell-Derived Arginase in Cancer Immune Response

(2020) Tomasz M. Grzywa et al.   Frontiers in Immunology

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

(2020) Alireza Labani-Motlagh et al.   Frontiers in Immunology

Amino Assets: How Amino Acids Support Immunity

(2020) Beth Kelly et al.   Cell Metabolism

Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective

(2020) Gonçalo S. Clemente et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Boronic acid-based arginase inhibitors in cancer immunotherapy

(2020) Bartlomiej Borek et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms, predictive factors, and future perspectives

(2020) Jin-Yu Sun et al.   Biomarker Research

Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase

(2019) Irena Roci et al.   Cell Reports

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

(2019) Malgorzata Czystowska-Kuzmicz et al.   Nature Communications

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

(2019) Georgina V Long et al.   LANCET ONCOLOGY

The arginase inhibitor Nω−hydroxy−nor−arginine (nor−NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target

(2018) King Pan Ng et al.   PLoS One

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

(2018) Christopher Groth et al.   BRITISH JOURNAL OF CANCER

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments

(2018) Jong W. Yu et al.   PLoS One

Critical role for arginase 2 in obesity-associated pancreatic cancer

(2017) Tamara Zaytouni et al.   Nature Communications

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

(2017) Kathrin Renner et al.   Frontiers in Immunology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

Cancer immunotherapy: the beginning of the end of cancer?

(2016) Sofia Farkona et al.   BMC Medicine

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity

(2015) F. Mussai et al.   CANCER RESEARCH

Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment

(2014) Alicja Chrzanowska et al.   CLINICAL BIOCHEMISTRY

Expression of arginase II in prostate cancer

(2014) Shannon Mumenthaler et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Repression of Arginase-2 Expression in Dendritic Cells by MicroRNA-155 Is Critical for Promoting T Cell Proliferation

(2014) Isabelle Dunand-Sauthier et al.   JOURNAL OF IMMUNOLOGY

“Of Mice and Men”: Arginine Metabolism in Macrophages

(2014) Anita C. Thomas et al.   Frontiers in Immunology

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

(2013) Adam Golebiowski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

(2013) F. Mussai et al.   BLOOD

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

(2013) Michael C. Van Zandt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer

(2013) Yoshinori Ino et al.   PLoS One

The Ratios of CD8+ T Cells to CD4+CD25+ FOXP3+ and FOXP3- T Cells Correlate with Poor Clinical Outcome in Human Serous Ovarian Cancer

(2013) Claudia C. Preston et al.   PLoS One

Correction: Proteomic Identification of Mitochondrial Targets of Arginase in Human Breast Cancer

(2013) Rajan Singh et al.   PLoS One

Altered functions of natural killer cells in response to L-Arginine availability

(2012) Bruno Lamas et al.   CELLULAR IMMUNOLOGY

Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma

(2012) Luc Bron et al.   INTERNATIONAL JOURNAL OF CANCER

Arginine metabolism in soft tissue sarcoma

(2011) Xiaofeng Yan et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

(2010) Barbara Delage et al.   INTERNATIONAL JOURNAL OF CANCER

Recent advances in arginine metabolism: roles and regulation of the arginases

(2009) Sidney M Morris Jr   BRITISH JOURNAL OF PHARMACOLOGY

Changes in arginase isoenzymes pattern in human hepatocellular carcinoma

(2008) Alicja Chrzanowska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

(2008) P. Serafini et al.   CANCER RESEARCH

Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma

(2008) David J Tate et al.   Journal of Hematology & Oncology