The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer

Phase II Study of Arginine Deprivation Therapy with Pegargiminase in Patients with Relapsed Sensitive or Refractory Small Cell Lung Cancer.

(2020) Peter E. Hall et al.   Clinical Lung Cancer

Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent

(2019) Ghenwa Nasreddine et al.   INVESTIGATIONAL NEW DRUGS

Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis

(2019) Alexandra Giatromanolaki et al.   MEDICAL ONCOLOGY

Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation

(2019) Pankaj K. Singh et al.   MOLECULAR CANCER THERAPEUTICS

Expression of enzymes related to glucose metabolism in non-small cell lung cancer and prognosis

(2017) Alexandra Giatromanolaki et al.   EXPERIMENTAL LUNG RESEARCH

Modulation of cancer-specific immune responses by amino acid degrading enzymes

(2017) Elina Timosenko et al.   Immunotherapy

CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis

(2017) Ran Lin et al.   MOLECULAR CELL

Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

(2017) Anke Werner et al.   Frontiers in Immunology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

Targeting arginine metabolism pathway to treat arginine-dependent cancers

(2015) Fuming Qiu et al.   CANCER LETTERS

iNOS Expression in CD4+ T Cells Limits Treg Induction by Repressing TGF 1: Combined iNOS Inhibition and Treg Depletion Unmask Endogenous Antitumor Immunity

(2014) P. Jayaraman et al.   CLINICAL CANCER RESEARCH

The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials

(2014) Anna Synakiewicz et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation

(2013) Jianjun Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

(2010) Barbara Delage et al.   INTERNATIONAL JOURNAL OF CANCER

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC)

(2009) Sam-Mui Tsui et al.   Cancer Cell International

Effect of arginine on angiogenesis induced by human colon cancer: in vitro and in vivo studies

(2009) Chiu-Li Yeh et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression

(2008) Rita Rotondo et al.   INTERNATIONAL JOURNAL OF CANCER