Lipid nanoparticle-based mRNA vaccines in cancers: Current advances and future prospects

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis

(2022) Lushan Peng et al.   Frontiers in Immunology

Single-cell sequencing: a promising approach for uncovering the mechanisms of tumor metastasis

(2022) Yingying Han et al.   Journal of Hematology & Oncology

Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial

(2021) Cassandra Aldrich et al.   VACCINE

Nanomaterial Delivery Systems for mRNA Vaccines

(2021) Michael D. Buschmann et al.   Vaccines

The role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors

(2021) Yiyang Zheng et al.   Molecular Cancer

mRNA vaccine for cancer immunotherapy

(2021) Lei Miao et al.   Molecular Cancer

Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development

(2021) Xing Huang et al.   Molecular Cancer

Identification of tumor antigens and immune subtypes of cholangiocarcinoma for mRNA vaccine development

(2021) Xing Huang et al.   Molecular Cancer

In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy

(2021) Yue Yin et al.   NANO LETTERS

The Emerging Landscape of Long Non-Coding RNAs in Colorectal Cancer Metastasis

(2021) Zhiming Liao et al.   Frontiers in Oncology

RNA-based therapies: A cog in the wheel of lung cancer defense

(2021) Parvez Khan et al.   Molecular Cancer

Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study

(2021) Jingxin Li et al.   NATURE MEDICINE

An Overview of Nanocarrier-Based Adjuvants for Vaccine Delivery

(2021) Kailash C. Petkar et al.   Pharmaceutics

Linking transport and translation of mRNAs with endosomes and mitochondria

(2021) Kira Müntjes et al.   EMBO REPORTS

Nanomaterials for cancer therapy: current progress and perspectives

(2021) Zhe Cheng et al.   Journal of Hematology & Oncology

Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

(2021) Yao-Xin Lin et al.   Science Translational Medicine

Lipid Nanoparticle–mRNA Formulations for Therapeutic Applications

(2021) Chang Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Sugar-Nanocapsules Imprinted with Microbial Molecular Patterns for mRNA Vaccination

(2020) Sejin Son et al.   NANO LETTERS

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Neuroma

(2020) Michael W. Neumeister et al.   CLINICS IN PLASTIC SURGERY

Nanotechnology for COVID-19: Therapeutics and Vaccine Research

(2020) Gaurav Chauhan et al.   ACS Nano

Recent advances in mRNA vaccine technology

(2020) Norbert Pardi et al.   CURRENT OPINION IN IMMUNOLOGY

Efficient Colorectal Cancer Gene Therapy with IL-15 mRNA Nano-formulation

(2020) Sibei Lei et al.   MOLECULAR PHARMACEUTICS

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo

(2020) Chunxi Zeng et al.   ADVANCED MATERIALS

Recent developments of RNA-based vaccines in cancer immunotherapy

(2020) Elnaz Faghfuri et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells

(2020) Vy Anh Tran et al.   International Journal of Nanomedicine

mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

(2020) Gal Cafri et al.   JOURNAL OF CLINICAL INVESTIGATION

AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response

(2020) Yujia Xia et al.   Molecular Oncology

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

(2020) Mohammad Ariful Islam et al.   BIOMATERIALS

DP7-C-modified liposomes enhance immune responses and the antitumor effect of a neoantigen-based mRNA vaccine

(2020) Rui Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders

(2020) Michal Caspi et al.   ADVANCED DRUG DELIVERY REVIEWS

Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection

(2020) Cole J. Batty et al.   ADVANCED DRUG DELIVERY REVIEWS

Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

(2019) Alexandros Papachristofilou et al.   Journal for ImmunoTherapy of Cancer

Biomaterials and Bioengineering Approaches for Mitochondria and Nuclear Targeting Drug Delivery

(2019) Md Nurunnabi et al.   ACS Biomaterials-Science & Engineering

Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer

(2019) Chengxiang Zhang et al.   Nano Research

pH-Responsive Polymer Nanoparticles for Drug Delivery

(2019) Nayeleh Deirram et al.   MACROMOLECULAR RAPID COMMUNICATIONS

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

(2019) Martin Sebastian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Broadening the Message: A Nanovaccine Co-loaded with Messenger RNA and α-GalCer Induces Antitumor Immunity through Conventional and Natural Killer T Cells

(2019) Rein Verbeke et al.   ACS Nano

Synthesis and investigations of ciprofloxacin loaded engineered selenium lipid nanocarriers for effective drug delivery system for preventing lung infections of interstitial lung disease

(2019) Jingjing Liu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy

(2019) Wesley de Jong et al.   Trials

Topical administration of nanocarrier miRNA‐210 antisense ameliorates imiquimod‐induced psoriasis‐like dermatitis in mice

(2019) Huan Feng et al.   JOURNAL OF DERMATOLOGY

Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy

(2019) Weijing Yang et al.   ACS Nano

Targeting YAP1/LINC00152/FSCN1 Signaling Axis Prevents the Progression of Colorectal Cancer

(2019) Chunlin Ou et al.   Advanced Science

Endogenous albumin-mediated delivery of redox-responsive paclitaxel-loaded micelles for targeted cancer therapy

(2018) Yujie Zhang et al.   BIOMATERIALS

5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes

(2018) Blazej A. Wojtczak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer

(2018) Lina Liu et al.   MOLECULAR THERAPY

Maximizing the translational yield of mRNA therapeutics by minimizing 5'-UTRs

(2018) Zeljka Trepotec et al.   TISSUE ENGINEERING PART A

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

(2018) Kevin Van der Jeught et al.   ACS Nano

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Biomedical applications of mRNA nanomedicine

(2018) Qingqing Xiong et al.   Nano Research

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

(2018) Mohammad Ariful Islam et al.   Nature Biomedical Engineering

Therapeutic targeting strategies using endogenous cells and proteins

(2017) Neha N. Parayath et al.   JOURNAL OF CONTROLLED RELEASE

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Induction of humoural and cellular immunity by immunisation with HCV particle vaccine in a non-human primate model

(2016) Hiroshi Yokokawa et al.   GUT

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations

(2016) Florian Buhr et al.   MOLECULAR CELL

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

(2016) Ans De Beuckelaer et al.   MOLECULAR THERAPY

Immunotherapy for lung cancer

(2016) Antonius Steven et al.   RESPIROLOGY

From the RNA world to the clinic

(2016) B. A. Sullenger et al.   SCIENCE

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

Who discovered messenger RNA?

(2015) Matthew Cobb   CURRENT BIOLOGY

Long-term survival correlates with immunological responses in renal cell carcinoma patients treated with mRNA-based immunotherapy

(2015) Susanne M. Rittig et al.   OncoImmunology

Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013

(2014) D. Papamichael et al.   ANNALS OF ONCOLOGY

A tumour mRNA-triggered nanocarrier for multimodal cancer cell imaging and therapy

(2014) Na Li et al.   CHEMICAL COMMUNICATIONS

A critical analysis of codon optimization in human therapeutics

(2014) Vincent P. Mauro et al.   TRENDS IN MOLECULAR MEDICINE

Prodrug-based nanoparticulate drug delivery strategies for cancer therapy

(2014) Cong Luo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

mRNA vaccine CV9103 and CV9104 for the treatment of prostate cancer

(2014) Steffen Rausch et al.   Human Vaccines & Immunotherapeutics

Application of gold nanoparticles in biomedical and drug delivery

(2014) Hadis Daraee et al.   Artificial Cells Nanomedicine and Biotechnology

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

(2014) Kenneth C McCullough et al.   Molecular Therapy-Nucleic Acids

Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma

(2013) Einar Osland Vik-Mo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Challenges and advances towards the rational design of mRNA vaccines

(2013) Charlotte Pollard et al.   TRENDS IN MOLECULAR MEDICINE

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

(2012) Julian R. Molina et al.   MAYO CLINIC PROCEEDINGS

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

Overcoming HLA restriction in clinical trials

(2012) An M.T. Van Nuffel et al.   OncoImmunology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Drug delivery and nanoparticles: Applications and hazards

(2010) de Jong   International Journal of Nanomedicine

mRNA as gene therapeutic: How to control protein expression

(2010) Geertrui Tavernier et al.   JOURNAL OF CONTROLLED RELEASE

Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR

(2010) Makoto Maemondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanomedicine

(2010) Betty Y.S. Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′,5′ bridge containing methylenebis(phosphonate) modification

(2009) Anna Maria Rydzik et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Coding-Sequence Determinants of Gene Expression in Escherichia coli

(2009) G. Kudla et al.   SCIENCE

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY