Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease

Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in mice

(2022) Eleonora Cremonini et al.   Food & Function

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum]

(2021) Xinxu Zhang et al.   Drug Design Development and Therapy

Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice

(2021) Beihui He et al.   BIOMEDICINE & PHARMACOTHERAPY

Malvidin-3-O-Glucoside from Blueberry Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Transcription Factor EB-Mediated Lysosomal Function and Activating the Nrf2/ARE Signaling Pathway

(2021) Yang Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Non-alcoholic fatty liver disease

(2021) Elizabeth E Powell et al.   LANCET

Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway

(2021) Dongdong Wu et al.   Oxidative Medicine and Cellular Longevity

Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis

(2021) Yan Xing et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats

(2021) Wenlan Zou et al.   Drug Design Development and Therapy

Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota

(2021) Wen-Long Sun et al.   Cell Reports

Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK

(2021) Ying Yang et al.   Frontiers in Pharmacology

Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism

(2021) Songsong Wang et al.   Journal of Advanced Research

Ameliorative Effect of Myricetin on Nonalcoholic Fatty Liver Disease in ob/ob Mice

(2021) Ha-Neul Choi et al.   JOURNAL OF MEDICINAL FOOD

Theaflavin TF3 Relieves Hepatocyte Lipid Deposition through Activating an AMPK Signaling Pathway by targeting Plasma Kallikrein

(2020) Wenji Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cyanidin‐3‐O‐glucoside improves non‐alcoholic fatty liver disease by promoting PINK1‐mediated mitophagy in mice

(2020) Xinwei Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combination of luteolin and lycopene effectively protect against the “two-hit” in NAFLD through Sirt1/AMPK signal pathway

(2020) Yaoxiang Zhu et al.   LIFE SCIENCES

Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes

(2020) Yana Geng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy

(2020) Xinxu Zhang et al.   Drug Design Development and Therapy

Catechin‐Rich Green Tea Extract and the Loss‐of‐TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis

(2020) Geoffrey Y. Sasaki et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effect of Daily Consumption of Orange Juice on the Levels of Blood Glucose, Lipids, and Gut Microbiota Metabolites: Controlled Clinical Trials

(2019) Ana Carolina Delgado Lima et al.   JOURNAL OF MEDICINAL FOOD

Protection against nonalcoholic steatohepatitis through targeting IL-18 and IL-1alpha by luteolin

(2019) Nashwa Abu-Elsaad et al.   Pharmacological Reports

Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet

(2019) Chian-Jiun Liou et al.   Cells

A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway

(2019) Ya-Jing Chen et al.   BRAIN RESEARCH BULLETIN

Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways

(2019) Yanan Lv et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db / db mice

(2019) Hao Yang et al.   PHYTOTHERAPY RESEARCH

Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice

(2019) Bihui Liu et al.   Biomolecules

Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice

(2019) Hongguang Xia et al.   BIOMEDICINE & PHARMACOTHERAPY

Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly

(2019) Xinhong Zhu et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory effects of flavonoids

(2019) Soheila J. Maleki et al.   FOOD CHEMISTRY

Evolution of NAFLD and Its Management

(2019) Manpreet S. Mundi et al.   NUTRITION IN CLINICAL PRACTICE

Kaempferol alleviates acute alcoholic liver injury in mice by regulating intestinal tight junction proteins and butyrate receptors and transporters

(2019) Jing Chen et al.   TOXICOLOGY

Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells

(2018) B. Huang et al.   BIOCHEMISTRY-MOSCOW

Higher serum carotenoids associated with improvement of non-alcoholic fatty liver disease in adults: a prospective study

(2018) Mian-li Xiao et al.   EUROPEAN JOURNAL OF NUTRITION

Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway

(2018) Xinhong Zhu et al.   FOOD AND CHEMICAL TOXICOLOGY

Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway

(2018) Xiaoxue Zhang et al.   FREE RADICAL RESEARCH

Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A2 Pathway

(2018) Wenzhe Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones

(2018) Antonella Lascala et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

(2018) Yan-Lan Fang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Antioxidant and prebiotic activity of five peonidin-based anthocyanins extracted from purple sweet potato (Ipomoea batatas (L.) Lam.)

(2018) Hanju Sun et al.   Scientific Reports

Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state

(2018) Hongming Su et al.   FREE RADICAL BIOLOGY AND MEDICINE

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy

(2018) Li Zhang et al.   Frontiers in Pharmacology

A higher flavonoid intake is associated with less likelihood of nonalcoholic fatty liver disease: results from a multiethnic study

(2018) Mohsen Mazidi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation

(2017) David Porras et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genistein Ameliorates Fat Accumulation Through AMPK Activation in Fatty Acid-Induced BRL Cells

(2017) Huijia Zhong et al.   JOURNAL OF FOOD SCIENCE

Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

(2017) Qian Tang et al.   Cell Death & Disease

Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats

(2017) Hua Fan et al.   MEDICAL SCIENCE MONITOR

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

(2016) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Bead-beating artefacts in the Bacteroidetes to Firmicutes ratio of the human stool metagenome

(2016) Heidi C. Vebø et al.   JOURNAL OF MICROBIOLOGICAL METHODS

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Gut–liver axis, nutrition, and non-alcoholic fatty liver disease

(2015) Irina A. Kirpich et al.   CLINICAL BIOCHEMISTRY

The potential of flavonoids in the treatment of non-alcoholic fatty liver disease

(2015) Bregje Van De Wier et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

(2015) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients

(2015) Guillaume Lassailly et al.   GASTROENTEROLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

The flavonoid, naringenin, decreases adipose tissue mass and attenuates ovariectomy-associated metabolic disturbances in mice

(2015) Jia-Yu Ke et al.   Nutrition & Metabolism

Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease

(2015) Weiwei Jiang et al.   Scientific Reports

Pathological Features of Fatty Liver Disease

(2014) Matthew M. Yeh et al.   GASTROENTEROLOGY

Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents

(2014) Oyekoya T Ayonrinde et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Pediatric non-alcoholic fatty liver disease: an increasing public health issue

(2013) S. Berardis et al.   EUROPEAN JOURNAL OF PEDIATRICS

Simple Noninvasive Systems Predict Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2013) Paul Angulo et al.   GASTROENTEROLOGY

Flavonoids: Their Structure, Biosynthesis and Role in the Rhizosphere, Including Allelopathy

(2013) Leslie A. Weston et al.   JOURNAL OF CHEMICAL ECOLOGY

NAFLD in Asia—as common and important as in the West

(2013) Geoffrey C. Farrell et al.   Nature Reviews Gastroenterology & Hepatology

The cocoa flavanol (−)-epicatechin protects the cortisol response

(2013) Erik J.B. Ruijters et al.   PHARMACOLOGICAL RESEARCH

Theaflavin attenuates ischemia–reperfusion injury in a mouse fatty liver model

(2011) Xiao-Yu Luo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Flavonoids and other Polyphenols on Inflammation

(2011) R. González et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Fruit polyphenols, immunity and inflammation

(2010) Javier González-Gallego et al.   BRITISH JOURNAL OF NUTRITION

Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism

(2010) M-H Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes

(2010) Giovanni Targher et al.   JOURNAL OF HEPATOLOGY

The role of the gut microbiota in nonalcoholic fatty liver disease

(2010) Ahmed Abu-Shanab et al.   Nature Reviews Gastroenterology & Hepatology

Structure-dependent membrane interaction of flavonoids associated with their bioactivity

(2009) Hironori Tsuchiya   FOOD CHEMISTRY

Decreased survival of subjects with elevated liver function tests during a 28-year follow-up

(2009) Cecilia Söderberg et al.   HEPATOLOGY

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance

(2008) M. Bell et al.   DIABETES

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS

Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease

(2008) Janice Jou et al.   SEMINARS IN LIVER DISEASE