Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet

Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer

(2019) Wen-Chung Huang et al.   Cells

Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A

(2019) Hongming Lv et al.   Cell Death & Disease

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer

(2019) Junfang Lyu et al.   Cells

Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated Sirt1/AMPK signaling pathway

(2018) Yi-Hsien Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity

(2018) Hongming Lv et al.   Frontiers in Pharmacology

Cholesterol biosensors: A review

(2018) Vinay Narwal et al.   STEROIDS

Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice

(2017) Xue Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Saponins from stems and leaves of Panax ginseng prevent obesity via regulating thermogenesis, lipogenesis and lipolysis in high-fat diet-induced obese C57BL/6 mice

(2017) Guilin Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Rutin exhibits hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease by reducing hepatic lipid levels and mitigating lipid-induced oxidative injuries

(2017) Qingsheng Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation

(2017) Rejina Afrin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroprotective effect of licochalcone A against oxygen-glucose deprivation/reperfusion in rat primary cortical neurons by attenuating oxidative stress injury and inflammatory response via the SIRT1/Nrf2 pathway

(2017) Xiaohong Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Water extract of Helminthostachys zeylanica attenuates LPS-induced acute lung injury in mice by modulating NF-κB and MAPK pathways

(2017) Chian-Jiun Liou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Treatment of NAFLD with diet, physical activity and exercise

(2017) Manuel Romero-Gómez et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease: A sign of systemic disease

(2017) Isabella Reccia et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice

(2017) You-Jin Choi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of Lipid Metabolism

(2017) Veronika Tillander et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments

(2017) Hironori Kitade et al.   Nutrients

Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a NAFLD/NASH mouse model

(2017) Alessandra Tessitore et al.   Oncotarget

Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma

(2017) Ranran Tang et al.   Oncotarget

Casticin inhibits interleukin-1β–induced ICAM-1 and MUC5AC expression by blocking NF-κB, PI3K-Akt, and MAPK signaling in human lung epithelial cells

(2017) Chian-Jiun Liou et al.   Oncotarget

Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver

(2017) Ahyoung Yoo et al.   Scientific Reports

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet

(2017) Angela Woods et al.   Cell Reports

Psoralea corylifolia L. Attenuates Nonalcoholic Steatohepatitis in Juvenile Mouse

(2017) Lishan Zhou et al.   Frontiers in Pharmacology

Acacetin from Traditionally Used Saussurea involucrata Kar. et Kir. Suppressed Adipogenesis in 3T3-L1 Adipocytes and Attenuated Lipid Accumulation in Obese Mice

(2017) Chian-Jiun Liou et al.   Frontiers in Pharmacology

Phloretin Attenuates Allergic Airway Inflammation and Oxidative Stress in Asthmatic Mice

(2017) Wen-Chung Huang et al.   Frontiers in Immunology

Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

(2017) Yinliang Zhang et al.   Molecular Metabolism

The role of adiponectin in obesity-associated female-specific carcinogenesis

(2016) Ganji Purnachandra Nagaraju et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver

(2016) Yueli Tian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet

(2016) Jinhui Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Silymarin Ameliorates Metabolic Dysfunction Associated with Diet-Induced Obesity via Activation of Farnesyl X Receptor

(2016) Ming Gu et al.   Frontiers in Pharmacology

Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity

(2015) Weichun Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease

(2015) Jae-Chul Jung et al.   BMC Complementary and Alternative Medicine

Resveratrol treatment rescues hyperleptinemia and improves hypothalamic leptin signaling programmed by maternal high-fat diet in rats

(2015) J. G. Franco et al.   EUROPEAN JOURNAL OF NUTRITION

Endocrine disruptors and obesity

(2015) Jerrold J. Heindel et al.   Nature Reviews Endocrinology

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells

(2015) Jen-Pi Tsai et al.   Oncotarget

Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levels

(2015) Jinfeng Liu et al.   Scientific Reports

Identification of Glycyrrhiza as the rikkunshito constituent with the highest antagonistic potential on heterologously expressed 5-HT3A receptors due to the action of flavonoids

(2015) Robin Herbrechter et al.   Frontiers in Pharmacology

Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue

(2015) Ivana Zagotta et al.   Frontiers in Pharmacology

AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1

(2014) Hee Yun et al.   FEBS Journal

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice

(2014) Irene Locatelli et al.   HEPATOLOGY

Curcumin and obesity

(2013) Peter G. Bradford   BIOFACTORS

Licochalcone A regulates hepatic lipid metabolism through activation of AMP-activated protein kinase

(2013) Hai Yan Quan et al.   FITOTERAPIA

Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation

(2013) Shumin Yang et al.   MEDIATORS OF INFLAMMATION

Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures

(2013) Wen-Chung Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases

(2013) Morihiro Matsuda et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets

(2012) Giulio R. Romeo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Licochalcone A Prevents Adipocyte Differentiation and Lipogenesis via Suppression of Peroxisome Proliferator-Activated Receptor γ and Sterol Regulatory Element-Binding Protein Pathways

(2012) Hai-Yan Quan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Bilirubin in Diabetes, Metabolic Syndrome, and Cardiovascular Diseases

(2012) Libor Vítek   Frontiers in Pharmacology

5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-Stimulated Hepatic Expression of Cyp4a10, Cyp4a14, Cyp4a31, and Other Peroxisome Proliferator-Activated Receptor  -Responsive Mouse Genes Is AICAR 5'-Monophosphate-Dependent and AMP-Activated Protein Kinase-Independent

(2011) N. N. Bumpus et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint

(2010) Francis I Achike et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

An energetic tale of AMPK-independent effects of metformin

(2010) Russell A. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK: a metabolic gauge regulating whole-body energy homeostasis

(2008) Ricardo Lage et al.   TRENDS IN MOLECULAR MEDICINE