NAFLD in Asia—as common and important as in the West

Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity

(2013) Yong-Ning Xin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Liver cholesterol: is it playing possum in NASH?

(2012) Geoffrey C. Farrell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls

(2012) Luca Valenti et al.   BMC GASTROENTEROLOGY

The Association between Nonalcoholic Fatty Liver Disease, Metabolic Syndrome and Arterial Stiffness in Nondiabetic, Nonhypertensive Individuals

(2012) Byung Jin Kim et al.   CARDIOLOGY

Independent Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in the US Population

(2012) Maria Stepanova et al.   Clinical Gastroenterology and Hepatology

Combined Influence of Insulin Resistance, Overweight/Obesity, and Fatty Liver as Risk Factors for Type 2 Diabetes

(2012) K.-C. Sung et al.   DIABETES CARE

Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials

(2012) G. Musso et al.   DIABETOLOGIA

Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-α-lowering property

(2012) Hideyuki Hyogo et al.   DIGESTIVE AND LIVER DISEASE

Hepatocellular carcinoma in nonalcoholic fatty liver cirrhosis and alcoholic cirrhosis

(2012) Deepali Jain et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

(2012) Kenneth Cusi   GASTROENTEROLOGY

Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis

(2012) Rohit Loomba et al.   HEPATOLOGY

Diabetes and hepatocellular cancer risk: Not only a matter of hyperglycemia

(2012) Giulio Marchesini et al.   HEPATOLOGY

Nonalcoholic fatty liver disease is associated with coronary artery calcification

(2012) Donghee Kim et al.   HEPATOLOGY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease

(2012) Shamsul Mohd Zain et al.   HUMAN GENETICS

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis

(2012) John Zhong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonalcoholic fatty liver disease in Asia: A story of growth

(2012) Vincent Wai-Sun Wong   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Exercise and diet modification in non-obese non-alcoholic fatty liver disease: Analysis of biopsies of living liver donors

(2012) Young-Joo Jin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

APOC3 and PNPLA3 in non-alcoholic fatty liver disease: Need to clear the air

(2012) Ajay Duseja et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Prevalence and risk factors for non-alcoholic fatty liver disease in Asian people who are not obese

(2012) Chun-Jen Liu   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity

(2012) Leon A Adams et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Potential for statins in the chemoprevention and management of hepatocellular carcinoma

(2012) Amedeo Lonardo et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro

(2012) Carlo Pirazzi et al.   JOURNAL OF HEPATOLOGY

A survey of patterns of practice and perception of NAFLD in a large sample of practicing gastroenterologists in France

(2012) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD)

(2012) Winston Dunn et al.   JOURNAL OF HEPATOLOGY

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insulin resistance at diagnosis in Japanese children with type 2 diabetes mellitus

(2012) Tatsuhiko Urakami et al.   PEDIATRICS INTERNATIONAL

Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

(2012) Takahisa Kawaguchi et al.   PLoS One

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis

(2012) Giovanni Musso et al.   PROGRESS IN LIPID RESEARCH

Protective effect of alcohol consumption for fatty liver but not metabolic syndrome

(2012) Masahide Hamaguchi   WORLD JOURNAL OF GASTROENTEROLOGY

Risk of Hepatocellular Carcinoma in Diabetic Patients and Risk Reduction Associated With Anti-Diabetic Therapy: A Population-Based Cohort Study

(2011) Shih-Wei Lai et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Physical Activity Recommendations, Exercise Intensity, and Histological Severity of Nonalcoholic Fatty Liver Disease

(2011) Kristin D Kistler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Large-Scale Long-Term Follow-Up Study of Japanese Patients With Non-Alcoholic Fatty Liver Disease for the Onset of Hepatocellular Carcinoma

(2011) Yusuke Kawamura et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Relative Etiological Role of Prior Hepatitis B Virus Infection and Nonalcoholic Fatty Liver Disease in the Development of Non-B Non-C Hepatocellular Carcinoma in a Hepatitis B-Endemic Area

(2011) Eun Ju Cho et al.   DIGESTION

Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease

(2011) V. W.-S. Wong et al.   GUT

High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis

(2011) V. W.-S. Wong et al.   GUT

Genetic determinants of alcoholic liver disease

(2011) Felix Stickel et al.   GUT

Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography

(2011) Vincent Wai-Sun Wong et al.   GUT

Sitagliptin as a Novel Treatment Agent for Non-Alcoholic Fatty Liver Disease Patients with Type 2 Diabetes Mellitus

(2011) Tomoyuki Iwasaki et al.   HEPATO-GASTROENTEROLOGY

Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial

(2011) Claudia O. Zein et al.   HEPATOLOGY

Diagnosing steatohepatitis and predicting liver-related mortality in patients with NAFLD: Two distinct concepts

(2011) Paul Angulo   HEPATOLOGY

Metabolic syndrome increases the risk of primary liver cancer in the United States: A study in the SEER-medicare database

(2011) Tania M. Welzel et al.   HEPATOLOGY

The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study

(2011) Neeraj Bhala et al.   HEPATOLOGY

Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality

(2011) Zobair M. Younossi et al.   HEPATOLOGY

Ethnicity and nonalcoholic fatty liver disease

(2011) Kiran Bambha et al.   HEPATOLOGY

Hepatocellular carcinoma in non-alcoholic steatohepatitis: Growing evidence of an epidemic?

(2011) Etsuko Hashimoto et al.   HEPATOLOGY RESEARCH

Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease

(2011) Cynthia D. Guy et al.   HUMAN PATHOLOGY

Histological features of non-alcoholic fatty liver disease: What is important?

(2011) Etsuko Hashimoto et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan

(2011) Takeshi Okanoue et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground

(2011) Shivakumar Chitturi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review

(2011) Christian Thoma et al.   JOURNAL OF HEPATOLOGY

Hepatitis B virus infection and fatty liver in the general population

(2011) Vincent Wai-Sun Wong et al.   JOURNAL OF HEPATOLOGY

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population

(2011) Chih-Wen Wang et al.   LIVER INTERNATIONAL

Metabolic Syndrome as a Risk Factor for Nonalcoholic Fatty Liver Disease

(2011) Chung-Huang Tsai et al.   SOUTHERN MEDICAL JOURNAL

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

(2010) V. W.-S. Wong et al.   GUT

Durability of peginterferon alfa-2b treatment at 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B

(2010) Vincent Wai-Sun Wong et al.   HEPATOLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

Correction: Betaine for nonalcoholic fatty liver disease: Results of a randomized placebo-controlled trial

(2010) Manal F. Abdelmalek et al.   HEPATOLOGY

Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease

(2010) Brent A. Neuschwander-Tetri et al.   HEPATOLOGY

Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease

(2010) Kausik Das et al.   HEPATOLOGY

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

(2010) Mustafa S. Ascha et al.   HEPATOLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Substantially increased risk of cancer in patients with diabetes mellitus

(2010) Hiroshi Noto et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease

(2010) Hyohun Park et al.   JOURNAL OF GASTROENTEROLOGY

A fresh look at NASH pathogenesis. Part 1: The metabolic movers

(2010) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Postprandial insulin secretion pattern is associated with histological severity in non-alcoholic fatty liver disease patients without prior known diabetes mellitus

(2010) Yuki Kimura et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Factors associated with unreliable liver stiffness measurement and its failure with transient elastography in the Chinese population

(2010) Grace L-H Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Postprandial hyperinsulinemia is universal in non-diabetic patients with nonalcoholic fatty liver disease

(2010) Jayani Manchanayake et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life

(2010) Stefano Romeo et al.   JOURNAL OF HEPATOLOGY

A position statement on NAFLD/NASH based on the EASL 2009 special conference

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

(2010) Vasilios G Athyros et al.   LANCET

The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

(2010) Jung Sub Lim et al.   Nature Reviews Gastroenterology & Hepatology

Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease

(2010) Kitt Falk Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk Factors for Liver Steatosis in Obese Children and Adolescents

(2010) Yu-Cheng Lin et al.   Pediatrics and Neonatology

Histopathology of nonalcoholic fatty liver disease

(2010) Elizabeth M Brunt   WORLD JOURNAL OF GASTROENTEROLOGY

Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARγ locus in Han Chinese

(2009) Hsin-Hung Chen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Relationship between uric acid and hepatic steatosis among Koreans

(2009) K. Lee   DIABETES & METABOLISM

Prevalence of non-alcoholic fatty liver disease in urban south Indians in relation to different grades of glucose intolerance and metabolic syndrome

(2009) V. Mohan et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease

(2009) Philippe Mathurin et al.   GASTROENTEROLOGY

Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men

(2009) Y Chang et al.   GUT

Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis

(2009) Kittichai Promrat et al.   HEPATOLOGY

Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the united states population

(2009) George N. Ioannou et al.   HEPATOLOGY

Highly Purified Eicosapentaenoic Acid Treatment Improves Nonalcoholic Steatohepatitis

(2009) Naoki Tanaka et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Clues from the carotids: An appraisal of cardiovascular disease risk in non-alcoholic fatty liver disease

(2009) Shivakumar Chitturi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Elevation of serum aminotransferase activity increases risk of carotid atherosclerosis in patients with non-alcoholic fatty liver disease

(2009) Chia-Chi Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population

(2009) Anuradha S Dassanayake et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup

(2009) Tamaki Yamada et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study

(2009) Youming Li et al.   JOURNAL OF HEPATOLOGY

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

(2009) Curtis K. Argo et al.   JOURNAL OF HEPATOLOGY

AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)

(2009) Hung Huynh et al.   JOURNAL OF HEPATOLOGY

Association of Raised Liver Transaminases With Physical Inactivity, Increased Waist–Hip Ratio, and Other Metabolic Morbidities in Severely Obese Children

(2009) Yung Seng Lee et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Parental history of type 2 diabetes mellitus, metabolic syndrome, and cardiometabolic risk factors in Asian Indian adolescents

(2009) Ranjit Mohan Anjana et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Variant in PNPLA3 is associated with alcoholic liver disease

(2009) Chao Tian et al.   NATURE GENETICS

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

(2008) Xin Yuan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan

(2008) Chi–Ling Chen et al.   GASTROENTEROLOGY

Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B

(2008) G L-H Wong et al.   GUT

Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease

(2008) Winston Dunn et al.   HEPATOLOGY

Prevalence and risk factors of hepatic steatosis and its impact on liver injury in Chinese patients with chronic hepatitis B infection

(2008) Jun-ping Shi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio

(2008) Shaohua Chen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

(2008) Naga Chalasani et al.   JOURNAL OF HEPATOLOGY

Epidemiology of non-alcoholic fatty liver disease in China

(2008) Jian-Gao Fan et al.   JOURNAL OF HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children

(2008) Chun-Lin Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY