Catechin‐Rich Green Tea Extract and the Loss‐of‐TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis

Anti-inflammatory Activities of Green Tea Catechins along the Gut-liver Axis in Nonalcoholic Fatty Liver Disease: Lessons Learned from Preclinical and Human Studies

(2020) Joanna K. Hodges et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Epigallocatechin gallate but not catechin prevents nonalcoholic steatohepatitis in mice similar to green tea extract while differentially affecting the gut microbiota

(2020) Priyankar Dey et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green tea extract prevents obesity in male mice by alleviating gut dysbiosis in association with improved intestinal barrier function that limits endotoxin translocation and adipose inflammation

(2019) Priyankar Dey et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia‐TLR4‐NFκB‐Mediated Inflammation

(2019) Geoffrey Y. Sasaki et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Glyoxalase 1 Modulation in Obesity and Diabetes

(2018) Naila Rabbani et al.   ANTIOXIDANTS & REDOX SIGNALING

Green tea extract protects against hepatic NFκB activation along the gut-liver axis in diet-induced obese mice with nonalcoholic steatohepatitis by reducing endotoxin and TLR4/MyD88 signaling

(2018) Jinhui Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet

(2018) Miso Nam et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice

(2018) Jinbao Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Inhibits Obesity, Metabolic Syndrome, and Fatty Liver Disease in High-Fat–Fed Mice

(2018) Mousumi Bose et al.   JOURNAL OF NUTRITION

Green tea extract treatment reduces NFκB activation in mice with diet-induced nonalcoholic steatohepatitis by lowering TNFR1 and TLR4 expression and ligand availability

(2017) Jinhui Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Plasma Metabolomics Reveals Steroidal Alkaloids as Novel Biomarkers of Tomato Intake in Mice

(2017) Morgan J. Cichon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism

(2016) Thibaut Duparc et al.   GUT

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Arginase 2 deficiency results in spontaneous steatohepatitis: A novel link between innate immune activation and hepatic de novo lipogenesis

(2015) Laura A. Navarro et al.   JOURNAL OF HEPATOLOGY

Green tea changes serum and liver metabolomic profiles in mice with high-fat diet-induced obesity

(2015) Lan-Sook Lee et al.   MOLECULAR NUTRITION & FOOD RESEARCH

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

(2014) Amandine Everard et al.   Nature Communications

Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to d-lactate

(2013) Christopher Masterjohn et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice

(2013) Maria Lauda Tomasi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary Fructose Feeding Increases Adipose Methylglyoxal Accumulation in Rats in Association with Low Expression and Activity of Glyoxalase-2

(2013) Christopher Masterjohn et al.   Nutrients

Obesity and Severe Obesity Forecasts Through 2030

(2012) Eric A. Finkelstein et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enhanced store-operated Ca2+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats

(2011) Xiao-Ru Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

(2011) Timea Csak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Green Tea Extract Suppresses NFκB Activation and Inflammatory Responses in Diet-Induced Obese Rats with Nonalcoholic Steatohepatitis

(2011) Hea Jin Park et al.   JOURNAL OF NUTRITION

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes

(2011) Min-Yu Chung et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress

(2011) Natalie Kelsey et al.   NUTRITIONAL NEUROSCIENCE

Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

(2010) Naila Rabbani et al.   AMINO ACIDS

Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

(2010) Hea Jin Park et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice

(2010) Jamil A Haque et al.   LABORATORY INVESTIGATION

Bile acid levels are increased in the liver of patients with steatohepatitis

(2009) Márcia M. Aranha et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY