Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway

Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end

(2021) Clinton K Lau et al.   EMBO JOURNAL

The Dynein Adaptor RILP Controls Neuronal Autophagosome Biogenesis, Transport, and Clearance

(2020) Noopur V. Khobrekar et al.   DEVELOPMENTAL CELL

Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein

(2020) Qingzhou Feng et al.   MOLECULAR BIOLOGY OF THE CELL

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice

(2020) Qiong Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

(2020) Verena Henrichs et al.   Nature Communications

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

(2019) Ricardo Celestino et al.   PLOS BIOLOGY

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2

(2019) Sarah E. Hill et al.   DEVELOPMENTAL CELL

Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin

(2019) Mohamed M. Elshenawy et al.   Nature Chemical Biology

The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C

(2019) Alison E. Twelvetrees et al.   JOURNAL OF CELL SCIENCE

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif

(2019) Fernando Vilela et al.   Scientific Reports

Neuronal autophagy and intercellular regulation of homeostasis in the brain

(2018) Aditi Kulkarni et al.   CURRENT OPINION IN NEUROBIOLOGY

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation

(2018) Rongde Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3

(2018) Joseph J.B. Cockburn et al.   STRUCTURE

DeepCoil – a fast and accurate prediction of coiled-coil domains in protein sequences

(2018) Jan Ludwiczak et al.   BIOINFORMATICS

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

(2018) Mara A. Olenick et al.   JOURNAL OF CELL BIOLOGY

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology

(2017) Swetha Gowrishankar et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation

(2017) Amanda L. Neisch et al.   JOURNAL OF CELL BIOLOGY

UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes

(2017) Bikash Choudhary et al.   PLoS Genetics

Coiled-coils: The long and short of it

(2016) Linda Truebestein et al.   BIOESSAYS

Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors

(2016) Ashley A. George et al.   BIOESSAYS

Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine

(2016) Amanda L. Lumsden et al.   BMC EVOLUTIONARY BIOLOGY

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

(2016) Andrea K.H. Stavoe et al.   DEVELOPMENTAL CELL

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction

(2016) Mara A. Olenick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

Characterization of axonal transport defects in Drosophila Huntingtin mutants

(2016) Kurt R. Weiss et al.   JOURNAL OF NEUROGENETICS

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Mechanism and Regulation of Cytoplasmic Dynein

(2015) Michael A. Cianfrocco et al.   Annual Review of Cell and Developmental Biology

Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization

(2015) Edward R. Ballister et al.   CURRENT BIOLOGY

Autophagosome dynamics in neurodegeneration at a glance

(2015) Y. C. Wong et al.   JOURNAL OF CELL SCIENCE

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes

(2014) Meng-meng Fu et al.   DEVELOPMENTAL CELL

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit

(2014) M. De Luca et al.   JOURNAL OF CELL SCIENCE

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

(2014) Y. C. Wong et al.   JOURNAL OF NEUROSCIENCE

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potential function for the Huntingtin protein as a scaffold for selective autophagy

(2014) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Integrated regulation of motor-driven organelle transport by scaffolding proteins

(2014) Meng-meng Fu et al.   TRENDS IN CELL BIOLOGY

Dynactin functions as both a dynamic tether and brake during dynein-driven motility

(2014) Swathi Ayloo et al.   Nature Communications

Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements

(2014) Max A. Schlager et al.   Cell Reports

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Peroxisomes take shape

(2013) Jennifer J. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes

(2013) Catherine M. Drerup et al.   PLoS Genetics

LOGICOIL—multi-state prediction of coiled-coil oligomeric state

(2012) Thomas L. Vincent et al.   BIOINFORMATICS

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

The Caenorhabditis elegans JIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein

(2011) M. Arimoto et al.   JOURNAL OF NEUROSCIENCE

Multicoil2: Predicting Coiled Coils and Their Oligomerization States from Sequence in the Twilight Zone

(2011) Jason Trigg et al.   PLoS One

Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport

(2011) A. Kunwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

(2010) Lukas C. Kapitein et al.   BIOPHYSICAL JOURNAL

Motor Coordination via a Tug-of-War Mechanism Drives Bidirectional Vesicle Transport

(2010) Adam G. Hendricks et al.   CURRENT BIOLOGY

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells

(2010) R. Gassmann et al.   GENES & DEVELOPMENT

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

(2010) Raúl Pardo et al.   Molecular Brain

Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes

(2009) Nicole Beeler et al.   BRAIN RESEARCH BULLETIN

ARF6 Interacts with JIP4 to Control a Motor Switch Mechanism Regulating Endosome Traffic in Cytokinesis

(2009) Guillaume Montagnac et al.   CURRENT BIOLOGY

A kinesin-13 mutant catalytically depolymerizes microtubules in ADP

(2008) Michael Wagenbach et al.   JOURNAL OF CELL BIOLOGY

Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors

(2008) M. J. I. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA