Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

Mechanism of NMDA Receptor Inhibition and Activation

(2016) Shujia Zhu et al.   CELL

Human GRIN2B variants in neurodevelopmental disorders

(2016) Chun Hu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structural basis of kainate subtype glutamate receptor desensitization

(2016) Joel R. Meyerson et al.   NATURE

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain

(2016) Annabel Romero-Hernandez et al.   NEURON

Pharmacology of triheteromeric N -Methyl- d -Aspartate Receptors

(2016) John Cheriyan et al.   NEUROSCIENCE LETTERS

Structure and organization of heteromeric AMPA-type glutamate receptors

(2016) Beatriz Herguedas et al.   SCIENCE

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

(2016) Jonathan A. Coleman et al.   Jove-Journal of Visualized Experiments

Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States

(2014) Katharina L. Dürr et al.   CELL

Controlling NMDA Receptor Subunit Composition Using Ectopic Retention Signals

(2014) D. Stroebel et al.   JOURNAL OF NEUROSCIENCE

Structural mechanism of glutamate receptor activation and desensitization

(2014) Joel R. Meyerson et al.   NATURE

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents

(2014) Rashek Kazi et al.   NATURE NEUROSCIENCE

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism

(2014) L. Chen et al.   SCIENCE

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

(2013) Joseph R Moskal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Amino-terminal Domain Tetramer Organization and Structural Effects of Zinc Binding in theN-Methyl-d-aspartate (NMDA) Receptor

(2013) Rita E. Sirrieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triheteromeric NMDA Receptors at Hippocampal Synapses

(2013) K. R. Tovar et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain

(2013) Shujia Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Influence of GluN2 subunit identity on NMDA receptor function

(2013) D.J.A. Wyllie et al.   NEUROPHARMACOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Structure and function of glutamate receptor amino terminal domains

(2011) Hiro Furukawa   JOURNAL OF PHYSIOLOGY-LONDON

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Triheteromeric NR1/NR2A/NR2B Receptors Constitute the MajorN-Methyl-d-aspartate Receptor Population in Adult Hippocampal Synapses

(2010) Claudia Rauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain

(2010) K. B. Hansen et al.   MOLECULAR PHARMACOLOGY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Memantine

(2009) Kate McKeage   CNS DRUGS

Crystal structure and association behaviour of the GluR2 amino-terminal domain

(2009) Rongsheng Jin et al.   EMBO JOURNAL

Molecular dynamics flexible fitting: A practical guide to combine cryo-electron microscopy and X-ray crystallography

(2009) Leonardo G. Trabuco et al.   METHODS

Mechanism of differential control of NMDA receptor activity by NR2 subunits

(2009) Marc Gielen et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE