Lipids, lysosomes, and autophagy

Lipid-Induced Endoplasmic Reticulum Stress Impairs Selective Autophagy at the Step of Autophagosome-Lysosome Fusion in Hepatocytes

(2016) Koichiro Miyagawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK

(2015) Jing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of protein tyrosine phosphatase 1B rescues against myocardial anomalies in high fat diet-induced obesity: Role of AMPK-dependent autophagy

(2015) Machender R. Kandadi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ghrelin Attenuated Lipotoxicity via Autophagy Induction and Nuclear Factor-κB Inhibition

(2015) Yuqing Mao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity

(2015) Hedi Soussi et al.   DIABETES

High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice

(2015) Kwan Yi Chu et al.   DIABETOLOGIA

Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis

(2015) T. Shpilka et al.   EMBO JOURNAL

High-fat diet induces cardiomyocyte apoptosis via the inhibition of autophagy

(2015) Hsiu-Ching Hsu et al.   EUROPEAN JOURNAL OF NUTRITION

Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells

(2015) Urosh Vilimanovich et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux

(2015) Lance M. Bollinger et al.   Obesity

Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

(2014) Roy Emanuel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes

(2014) Mako Yasuda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice

(2014) Ying Liu et al.   DIABETES

High-fat feeding does not induce an autophagic or apoptotic phenotype in female rat skeletal muscle

(2014) Troy L Campbell et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death

(2014) Shakeel U. R. Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

(2014) Raquel Fucho et al.   JOURNAL OF HEPATOLOGY

Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity

(2014) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes

(2014) Myra E. Woodworth-Hobbs et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

β-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation

(2013) Analyn Lizaso et al.   Autophagy

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle

(2013) Pierre-Marie Badin et al.   ENDOCRINOLOGY

Biochemistry and pathophysiology of intravascular and intracellular lipolysis

(2013) S. G. Young et al.   GENES & DEVELOPMENT

Defective regulation of adipose tissue autophagy in obesity

(2013) C E Nuñez et al.   INTERNATIONAL JOURNAL OF OBESITY

Regulation of lipid accumulation by AMK-activated kinase in high fat diet–induced kidney injury

(2013) Anne-Emilie Declèves et al.   KIDNEY INTERNATIONAL

Transactivation of Atg4b by C/EBPβ Promotes Autophagy To Facilitate Adipogenesis

(2013) Liang Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

(2013) Larysa V. Yuzefovych et al.   PLoS One

Nox2-Derived Superoxide Contributes to Cerebral Vascular Dysfunction in Diet-Induced Obesity

(2013) Cynthia M. Lynch et al.   STROKE

FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment

(2013) D Lettieri Barbato et al.   Cell Death & Disease

Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

(2013) Sovan Sarkar et al.   Cell Reports

Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation

(2012) Agnieszka Gornicka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transition From Obesity to Metabolic Syndrome Is Associated With Altered Myocardial Autophagy and Apoptosis

(2012) Zi-Lun Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SnapShot: mTORC1 Signaling at the Lysosomal Surface

(2012) Liron Bar-Peled et al.   CELL

Lipids and Lysosomes

(2012) Isabelle Hamer et al.   CURRENT DRUG METABOLISM

Mechanisms of Lipotoxicity in the Cardiovascular System

(2012) Adam R. Wende et al.   CURRENT HYPERTENSION REPORTS

Cathepsin K Knockout Mitigates High-Fat Diet-Induced Cardiac Hypertrophy and Contractile Dysfunction

(2012) Y. Hua et al.   DIABETES

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy Activity Is Up-Regulated in Adipose Tissue of Obese Individuals and Modulates Proinflammatory Cytokine Expression

(2012) H. J. Jansen et al.   ENDOCRINOLOGY

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Autophagy, signaling and obesity

(2012) Vanessa J. Lavallard et al.   PHARMACOLOGICAL RESEARCH

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice

(2012) V. Moresi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation

(2012) Xihui Xu et al.   Journal of Molecular Cell Biology

Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function

(2011) Matthew J. Watt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Biogenesis and Cargo Selectivity of Autophagosomes

(2011) Hilla Weidberg et al.   Annual Review of Biochemistry

Lysosomal Function and Dysfunction: Mechanism and Disease

(2011) Patricia Boya   ANTIOXIDANTS & REDOX SIGNALING

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acids Suppress Autophagic Turnover in β-Cells

(2011) Guy Las et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Systemic upregulation of NADPH oxidase in diet-induced obesity in rats

(2011) Fan Jiang et al.   REDOX REPORT

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Lysosomal Lipid Storage Diseases

(2011) H. Schulze et al.   Cold Spring Harbor Perspectives in Biology

Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications

(2011) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications

(2010) Mark J. Czaja   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation

(2010) Masahiro Shibata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

Recent insights into factors affecting remnant lipoprotein uptake

(2010) Kevin Jon Williams et al.   CURRENT OPINION IN LIPIDOLOGY

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

(2010) Alessandro Fraldi et al.   EMBO JOURNAL

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

Autophagy in skeletal muscle

(2010) Marco Sandri   FEBS LETTERS

Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress

(2010) Yongjun Wang et al.   HEPATOLOGY

Autophagy plays a protective role in free cholesterol overload-induced death of smooth muscle cells

(2010) Kedi Xu et al.   JOURNAL OF LIPID RESEARCH

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Group XV phospholipase A2, a lysosomal phospholipase A2

(2010) James A. Shayman et al.   PROGRESS IN LIPID RESEARCH

Electrophysiology of Reactive Oxygen Production in Signaling Endosomes

(2009) Fred S. Lamb et al.   ANTIOXIDANTS & REDOX SIGNALING

The MAP1-LC3 conjugation system is involved in lipid droplet formation

(2009) Masahiro Shibata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fatty liver and lipotoxicity

(2009) Michael Trauner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lysosomal degradation of membrane lipids

(2009) Thomas Kolter et al.   FEBS LETTERS

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplets at a glance

(2009) Y. Guo et al.   JOURNAL OF CELL SCIENCE

Examination of ‘lipotoxicity’ in skeletal muscle of high-fat fed andob/obmice

(2009) S. M. Turpin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress and Autophagy in the Regulation of Lysosome-Dependent Neuron Death

(2008) Violetta N. Pivtoraiko et al.   ANTIOXIDANTS & REDOX SIGNALING

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Uptake of postprandial lipoproteins into bone in vivo: Impact on osteoblast function

(2008) Andreas Niemeier et al.   BONE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

The role of autophagy in the heart

(2008) K Nishida et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Protective Role of Autophagy in Palmitate-Induced INS-1 β-Cell Death

(2008) Sung-E Choi et al.   ENDOCRINOLOGY

Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells

(2008) Teresa Coll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY