Interferon beta attenuates recognition memory impairment and improves brain glucose uptake in a rat model of Alzheimer's disease: Involvement of mitochondrial biogenesis and PI3K pathway

Glucose Metabolic Dysfunction in Neurodegenerative Diseases—New Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming

(2021) Rongrong Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial biogenesis: An update

(2020) Lucia‐Doina Popov   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

(2020) Sergio Rius-Pérez et al.   Oxidative Medicine and Cellular Longevity

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

(2020) Fei Xu et al.   Cell and Bioscience

Regional disconnection in Alzheimer dementia and amyloid positive MCI: Association of EEG functional connectivity and brain glucose metabolism

(2020) Una Smailovic et al.   Brain Connectivity

Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

(2020) Zeinab Breijyeh et al.   MOLECULES

Prestimulation of Microglia Through TLR4 Pathway Promotes Interferon Beta Expression in a Rat Model of Alzheimer’s Disease

(2019) Niloufar Yousefi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

(2019) Giuseppa Mudò et al.   Journal of Neuroinflammation

Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying mechanism

(2019) Sara Chavoshinezhad et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Imaging and Spectral Characteristics of Amyloid Plaque Autofluorescence in Brain Slices from the APP/PS1 Mouse Model of Alzheimer’s Disease

(2019) Yunling Gao et al.   Neuroscience Bulletin

Intranasal interferon beta improves memory and modulates inflammatory responses in a mutant APP-overexpressing rat model of Alzheimer’s disease

(2019) Sara Chavoshinezhad et al.   BRAIN RESEARCH BULLETIN

NEMA NU‐4 2008 performance evaluation of Xtrim‐PET: A prototype SiPM‐based preclinical scanner

(2019) Mahsa Amirrashedi et al.   MEDICAL PHYSICS

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

(2019) Sami Gabbouj et al.   Frontiers in Neuroscience

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Triggering microglia through toll-like receptor 2 pathway induced interferon β expression in cell and animal model of Alzheimer’s disease

(2018) Nooshin Heshmati-Fakhr et al.   NEUROREPORT

Non-motor Behavioral Alterations of PGC-1α-Deficient Mice – A Peculiar Phenotype With Slight Male Preponderance and No Apparent Progression

(2018) Levente Szalardy et al.   Frontiers in Behavioral Neuroscience

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

(2018) Karina Sánchez-Alegría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

(2017) Ravi Rajmohan et al.   JOURNAL OF ALZHEIMERS DISEASE

Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta Gene Therapy, Using a Long-Term Expression Plasmid Vector

(2017) Atsushi Hamana et al.   MOLECULAR PHARMACEUTICS

Neuroprotective Effects of Aged Garlic Extract on Cognitive Dysfunction and Neuroinflammation Induced by β-Amyloid in Rats

(2017) Nutchareeporn Nillert et al.   Nutrients

Behavioral Changes and Hippocampus Glucose Metabolism in APP/PS1 Transgenic Mice via Electro-acupuncture at Governor Vessel Acupoints

(2017) Jin Cao et al.   Frontiers in Aging Neuroscience

The innovative development in interferon beta treatments of relapsing-remitting multiple sclerosis

(2017) Claus Madsen   Brain and Behavior

Differential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer’s disease

(2017) Valentine Hamm et al.   Science Advances

IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury

(2017) Victoria E. Thaney et al.   Scientific Reports

Intranasal Administration of Interferon Beta Attenuates Neuronal Apoptosis via the JAK1/STAT3/BCL-2 Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy

(2016) Brandon J. Dixon et al.   ASN Neuro

The Emerging Therapeutic Role of NGF in Alzheimer’s Disease

(2016) Chao-Jin Xu et al.   NEUROCHEMICAL RESEARCH

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

(2016) Line S. Reinert et al.   Nature Communications

Nerve growth factor-induced Akt/mTOR activation protects the ischemic heart via restoring autophagic flux and attenuating ubiquitinated protein accumulation

(2016) Zhou-Guang Wang et al.   Oncotarget

Interferon‐β Modulates Inflammatory Response in Cerebral Ischemia

(2016) Ping‐Chang Kuo et al.   Journal of the American Heart Association

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

(2015) Patrick Ejlerskov et al.   CELL

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

(2015) K Palikaras et al.   CELL DEATH AND DIFFERENTIATION

Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer’s disease

(2015) Ana Knezovic et al.   JOURNAL OF NEURAL TRANSMISSION

Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain

(2015) Cathleen Pfefferkorn et al.   JOURNAL OF VIROLOGY

Interferon beta (IFN-β) treatment exerts potential neuroprotective effects through neurotrophic factors and novel neurotensin/neurotensin high affinity receptor 1 pathway

(2015) Yang Mao-Draayer et al.   Neural Regeneration Research

A novel rat model of Alzheimer’s disease based on lentiviral-mediated expression of mutant APP

(2015) S. Parsi et al.   NEUROSCIENCE

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks

(2014) King-Hwa Ling et al.   BMC GENOMICS

Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenation

(2014) Jaswinder Sharma et al.   BMC NEUROSCIENCE

Nerve Growth Factor (NGF) Regulates Activity of Nuclear Factor of Activated T-cells (NFAT) in Neurons via the Phosphatidylinositol 3-Kinase (PI3K)-Akt-Glycogen Synthase Kinase 3β (GSK3β) Pathway

(2014) Man-Su Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of interferon-beta on neural stem cells and in a mouse model of multiple sclerosis

(2014) Sarah Stahlke et al.   JOURNAL OF NEUROIMMUNOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

PGC-1  Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from Parvalbumin-Positive Interneurons

(2014) E. K. Lucas et al.   JOURNAL OF NEUROSCIENCE

Beta Interferon Regulation of Glucose Metabolism Is PI3K/Akt Dependent and Important for Antiviral Activity against Coxsackievirus B3

(2014) J. D. Burke et al.   JOURNAL OF VIROLOGY

Interferon beta induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice

(2013) Alice Chort et al.   BRAIN

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β

(2013) Derek A. Costello et al.   HIPPOCAMPUS

PD-L1 Expression by Neurons Nearby Tumors Indicates Better Prognosis in Glioblastoma Patients

(2013) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

Subcutaneous Interferon β-1a May Protect against Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: 5-Year Follow-up of the COGIMUS Study

(2013) Francesco Patti et al.   PLoS One

PI3K/Akt Signal Pathway Involved in the Cognitive Impairment Caused by Chronic Cerebral Hypoperfusion in Rats

(2013) Yi Shu et al.   PLoS One

Mitochondria impact brain function and cognition

(2013) M. Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment

(2013) Y. Hara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Relationship between imaging biomarkers, age, progression and symptom severity in Alzheimer's disease

(2013) Juergen Dukart et al.   NeuroImage-Clinical

Interferon-β Delivery via Human Neural Stem Cell Abates Glial Scar Formation in Spinal Cord Injury

(2012) Yusuke Nishimura et al.   CELL TRANSPLANTATION

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Preplaque (‘Preclinical’) Aß-Induced Inflammation and Nerve Growth Factor Deregulation in Transgenic Models of Alzheimer’s Disease-Like Amyloid Pathology

(2012) A.C. Cuello et al.   Neurodegenerative Diseases

Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease

(2012) Li-Wen Chen et al.   NEUROPHARMACOLOGY

NGF, Brain and Behavioral Plasticity

(2012) Alessandra Berry et al.   NEURAL PLASTICITY

Imaging of microglia in patients with neurodegenerative disorders

(2012) Marios Politis   Frontiers in Pharmacology

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Interferon β-1b directly modulates human neural stem/progenitor cell fate

(2011) W. Tristram Arscott et al.   BRAIN RESEARCH

Direct Effects of Type I Interferons on Cells of the Immune System

(2011) S. Hervas-Stubbs et al.   CLINICAL CANCER RESEARCH

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Mitochondria and Neuroplasticity

(2010) Aiwu Cheng et al.   ASN Neuro

CREB: a multifaceted regulator of neuronal plasticity and protection

(2010) Kensuke Sakamoto et al.   JOURNAL OF NEUROCHEMISTRY

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

The effect of interferon-β on mouse neural progenitor cell survival and differentiation

(2009) Marek Hirsch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of neuron mitochondrial biogenesis and relevance to brain health

(2009) Isaac G. Onyango et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Amyloid β-Induced Nerve Growth Factor Dysmetabolism in Alzheimer Disease

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

(2009) Shyeilla V. Dhuria et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial

(2009) Ludwig Kappos et al.   LANCET NEUROLOGY

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Effects of immunomodulatory treatment with subcutaneous interferon beta-1a oncognitive decline in mildly disabled patients with relapsing—remitting multiple sclerosis

(2009) F. Patti et al.   Multiple Sclerosis Journal

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH