BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1

Molecular basis of ciliary defects caused by compound heterozygous IFT144/WDR19 mutations found in cranioectodermal dysplasia

(2021) Yamato Ishida et al.   HUMAN MOLECULAR GENETICS

Post-translational modification enzymes as key regulators of ciliary protein trafficking

(2021) Taro Chaya et al.   JOURNAL OF BIOCHEMISTRY

Bardet-Biedl Syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome

(2021) Yan-Xia Liu et al.   eLife

In vivo imaging shows continued association of several IFT-A, IFT-B and dynein complexes while IFT trains U-turn at the tip

(2021) Jenna L. Wingfield et al.   JOURNAL OF CELL SCIENCE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

RNA editing restricts hyperactive ciliary kinases

(2021) Dongdong Li et al.   SCIENCE

ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane

(2021) Sayaka Fujisawa et al.   Biology Open

xbx-4, a homolog of the Joubert syndrome gene FAM149B1, acts via the CCRK and RCK kinase cascade to regulate cilia morphology

(2021) Ashish K. Maurya et al.   CURRENT BIOLOGY

CCRK/CDK20 regulates ciliary retrograde protein trafficking via interacting with BROMI/TBC1D32

(2021) Tatsuro Noguchi et al.   PLoS One

Expanding the Phenotype of the FAM149B1-Related Ciliopathy and Identification of Three Neurogenetic Disorders in a Single Family

(2021) Sandy Siegert et al.   Genes

Loss-of-function variants in TBC1D32 underlie syndromic hypopituitarism

(2020) Johanna Hietamäki et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

(2020) Ahmad Abdelzaher Zaki Khalifa et al.   eLife

Architecture of the IFT ciliary trafficking machinery and interplay between its components

(2020) Kazuhisa Nakayama et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Confirming TBC1D32 ‐related ciliopathy in humans

(2020) Nada Alsahan et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the IFT machinery is required for intraciliary retrograde protein trafficking

(2020) Kentaro Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of the B9-domain protein complex MKS1–B9D2–B9D1 is essential as a diffusion barrier for ciliary membrane proteins

(2020) Misato Okazaki et al.   MOLECULAR BIOLOGY OF THE CELL

Developmental and regenerative paradigms of cilia regulated hedgehog signaling

(2020) Daniel Kopinke et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function

(2020) Casey D. Gailey et al.   DEVELOPMENTAL DYNAMICS

Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import

(2020) Takuya Kobayashi et al.   MOLECULAR BIOLOGY OF THE CELL

A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia

(2019) Tyler Picariello et al.   JOURNAL OF CELL SCIENCE

Cellular signalling by primary cilia in development, organ function and disease

(2019) Zeinab Anvarian et al.   Nature Reviews Nephrology

Regulation of flagellar assembly and length in Chlamydomonas by LF4, a MAPK-related kinase

(2019) Yingrui Wang et al.   FASEB JOURNAL

Bi-allelic Mutations in FAM149B1 Cause Abnormal Primary Cilium and a Range of Ciliopathy Phenotypes in Humans

(2019) Ranad Shaheen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A CCRK and a MAK Kinase Modulate Cilia Branching and Length via Regulation of Axonemal Microtubule Dynamics in Caenorhabditis elegans

(2019) Ashish Kumar Maurya et al.   CURRENT BIOLOGY

Establishing and regulating the composition of cilia for signal transduction

(2019) Maxence V. Nachury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena

(2019) Yu-Yang Jiang et al.   PLoS Genetics

Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis

(2019) Yoon Seon Oh et al.   Cells

Ciliogenesis associated kinase 1: targets and functions in various organ systems

(2019) Zheng Fu et al.   FEBS LETTERS

Structure of the dynein-2 complex and its assembly with intraflagellar transport trains

(2019) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia

(2019) Shohei Nozaki et al.   Biology Open

Structure of the Decorated Ciliary Doublet Microtubule

(2019) Meisheng Ma et al.   CELL

Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse

(2018) Chengbing Wang et al.   DEVELOPMENT

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

(2018) Fan Ye et al.   JOURNAL OF CELL BIOLOGY

Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking

(2018) Yuki Hamada et al.   MOLECULAR BIOLOGY OF THE CELL

BBS1 is involved in retrograde trafficking of ciliary GPCRs in the context of the BBSome complex

(2018) Shohei Nozaki et al.   PLoS One

The Bardet–Biedl syndrome protein complex is an adapter expanding the cargo range of intraflagellar transport trains for ciliary export

(2018) Peiwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The kinases male germ cell-associated kinase and cell cycle-related kinase regulate kinesin-2 motility in Caenorhabditis elegans neuronal cilia

(2018) Peishan Yi et al.   TRAFFIC

TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia

(2018) Sarina Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum

(2018) Eloïse Bertiaux et al.   JOURNAL OF CELL BIOLOGY

The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia

(2018) Mareike A. Jordan et al.   NATURE CELL BIOLOGY

Single-Molecule Turnarounds of Intraflagellar Transport at the C. elegans Ciliary Tip

(2018) Jona Mijalkovic et al.   Cell Reports

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

(2017) Hemant B. Badgandi et al.   JOURNAL OF CELL BIOLOGY

Ick Ciliary Kinase Is Essential for Planar Cell Polarity Formation in Inner Ear Hair Cells and Hearing Function

(2017) Shio Okamoto et al.   JOURNAL OF NEUROSCIENCE

RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly

(2017) Yuya Nishijima et al.   MOLECULAR BIOLOGY OF THE CELL

Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

(2017) Tomoaki Hirano et al.   MOLECULAR BIOLOGY OF THE CELL

Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system

(2017) Yohei Katoh et al.   MOLECULAR BIOLOGY OF THE CELL

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice

(2017) Ashley Snouffer et al.   PLoS Genetics

Dynamics of the IFT machinery at the ciliary tip

(2017) Alexander Chien et al.   eLife

An inactivating mutation in intestinal cell kinase,ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome

(2016) S. Paige Taylor et al.   HUMAN MOLECULAR GENETICS

Microtubule doublets are double-track railways for intraflagellar transport trains

(2016) L. Stepanek et al.   SCIENCE

The Intraflagellar Transport Machinery

(2016) Michael Taschner et al.   Cold Spring Harbor Perspectives in Biology

Ciliopathies

(2016) Daniela A. Braun et al.   Cold Spring Harbor Perspectives in Biology

Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition

(2016) Francesc R. Garcia-Gonzalo et al.   Cold Spring Harbor Perspectives in Biology

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

(2016) Karsten Boldt et al.   Nature Communications

Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins

(2015) Y. Katoh et al.   JOURNAL OF CELL SCIENCE

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

(2015) X. Li et al.   Molecular Systems Biology

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport

(2014) T. Chaya et al.   EMBO JOURNAL

FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas

(2014) Haru-aki Yanagisawa et al.   MOLECULAR BIOLOGY OF THE CELL

Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling

(2014) H. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules

(2014) T. Mendes Maia et al.   Biology Open

CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner

(2013) Ying Yang et al.   EMBO REPORTS

Ciliary GenesTBC1D32/C6orf170andSCLT1are Mutated in Patients with OFD Type IX

(2013) Nouran Adly et al.   HUMAN MUTATION

The conserved ciliary protein Bug22 controls planar beating of Chlamydomonas flagella

(2013) D. Meng et al.   JOURNAL OF CELL SCIENCE

Proteomic Analysis of Mammalian Primary Cilia

(2012) Hiroaki Ishikawa et al.   CURRENT BIOLOGY

Rab11 regulates exocytosis of recycling vesicles at the plasma membrane

(2012) Senye Takahashi et al.   JOURNAL OF CELL SCIENCE

Broad-Minded Links Cell Cycle-Related Kinase to Cilia Assembly and Hedgehog Signal Transduction

(2010) Hyuk Wan Ko et al.   DEVELOPMENTAL CELL

Bug22p, a Conserved Centrosomal/Ciliary Protein Also Present in Higher Plants, Is Required for an Effective Ciliary Stroke in Paramecium

(2010) C. Laligné et al.   EUKARYOTIC CELL

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival

(2010) Y. Omori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Multiplex Human Syndrome Implicates a Key Role for Intestinal Cell Kinase in Development of Central Nervous, Skeletal, and Endocrine Systems

(2009) Piya Lahiry et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Intersectin Regulates Dendritic Spine Development and Somatodendritic Endocytosis but Not Synaptic Vesicle Recycling in Hippocampal Neurons

(2009) Sébastien Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY