Pathophysiological involvement of host mitochondria in SARS-CoV-2 infection that causes COVID-19: a comprehensive evidential insight

Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV-2

(2022) Artem Pliss et al.   ACS Chemical Neuroscience

SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment

(2022) Chao Shang et al.   Frontiers in Microbiology

SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection

(2022) Xiaolin Zhang et al.   Autophagy

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

(2022) Elena Garreta et al.   Cell Metabolism

SARS-CoV-2 infects human cardiac myocytes promoted by inflammation and oxidative stress

(2022) Melina Tangos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Glycolytic inhibitor 2-deoxy-d-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions

(2022) Anant Narayan Bhatt et al.   LIFE SCIENCES

Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial

(2022) Alan Cash et al.   Journal of Translational Medicine

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding

(2021) Chun-Shik Shin et al.   Nature Communications

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

(2021) Brendan Miller et al.   Scientific Reports

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

(2021) Xin Yin et al.   Cell Reports

STING, the Endoplasmic Reticulum, and Mitochondria: Is Three a Crowd or a Conversation?

(2021) Judith A. Smith   Frontiers in Immunology

Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

(2021) Davide Scozzi et al.   JCI Insight

Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis

(2021) Roberta Nardacci et al.   Cell Death & Disease

SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

(2021) Jing Wu et al.   Cell Reports

Metabolic Alterations in SARS-CoV-2 Infection and Its Implication in Kidney Dysfunction

(2021) Magaiver Andrade Silva et al.   Frontiers in Physiology

Role of Mitochondria in Viral Infections

(2021) Srikanth Elesela et al.   Life-Basel

SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling pathways

(2021) Lulu Han et al.   JOURNAL OF MEDICAL VIROLOGY

Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions

(2021) Xiaopan Gao et al.   Nature Communications

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

(2021) Peter J. Mullen et al.   Nature Communications

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

(2021) Komudi Singh et al.   Frontiers in Genetics

Distinct Mitochondria-Mediated T-Cell Apoptosis Responses in Children and Adults With Coronavirus Disease 2019

(2021) Yang Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Host metabolic reprogramming in response to SARS-CoV-2 infection: A systems biology approach

(2021) S.T.R. Moolamalla et al.   MICROBIAL PATHOGENESIS

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs

(2021) David M. Kern et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

(2021) Pan Pan et al.   Nature Communications

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

(2021) Nils C. Gassen et al.   Nature Communications

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

(2021) Mahmoud AbuEid et al.   iScience

The effect of low serum calcium level on the severity and mortality of Covid patients: A systematic review and meta‐analysis

(2021) Effat Alemzadeh et al.   Immunity Inflammation and Disease

Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage

(2021) Tiago J. Costa et al.   VASCULAR PHARMACOLOGY

Peripheral Blood Mitochondrial DNA Levels Were Modulated by SARS-CoV-2 Infection Severity and Its Lessening Was Associated With Mortality Among Hospitalized Patients With COVID-19

(2021) José J. Valdés-Aguayo et al.   Frontiers in Cellular and Infection Microbiology

Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection

(2021) Chiara Mandò et al.   Antioxidants

Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and dynamics simulations

(2021) Seshu Vardhan et al.   Journal of Traditional and Complementary Medicine

Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway

(2020) Jie-qiong Song et al.   ACTA PHARMACOLOGICA SINICA

Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay

(2020) Xiujuan Wei et al.   JOURNAL OF HUMAN GENETICS

Mitochondrial Interactome: A Focus on Antiviral Signaling Pathways

(2020) Giulia Refolo et al.   Frontiers in Cell and Developmental Biology

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

COVID-19 and Multiorgan Response

(2020) Sevim Zaim et al.   CURRENT PROBLEMS IN CARDIOLOGY

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

(2020) Denisa Bojkova et al.   NATURE

Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

(2020) Yan Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical characteristics of older and younger patients infected with SARS-CoV-2

(2020) Zhiguo Zhou et al.   Aging-US

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

(2020) Keshav K. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

(2020) He-wei Jiang et al.   Cellular & Molecular Immunology

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

(2020) Víctor J. Costela-Ruiz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Is Antioxidant Therapy a Useful Complementary Measure for Covid-19 Treatment? An Algorithm for Its Application

(2020) María Elena Soto et al.   Medicina-Lithuania

Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York

(2020) Leonidas Palaiodimos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Double-Membrane Vesicles as Platforms for Viral Replication

(2020) Georg Wolff et al.   TRENDS IN MICROBIOLOGY

RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus

(2020) Kevin E. Wu et al.   Cell Systems

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies

(2020) Praveen Mathews Varghese et al.   IMMUNOBIOLOGY

Susceptibility to COVID‐19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants

(2020) Yunyi Yao et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

COVID‐19 infection induces readily detectable morphologic and inflammation‐related phenotypic changes in peripheral blood monocytes

(2020) Dan Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The COVID-19 Effect on the Immune System and Mitochondrial Dynamics in Diabetes, Obesity, and Dementia

(2020) Katherine Holder et al.   NEUROSCIENTIST

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

Mitochondria Targeted Viral Replication and Survival Strategies—Prospective on SARS-CoV-2

(2020) Priya Gatti et al.   Frontiers in Pharmacology

Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2

(2020) Nancy Ashary et al.   Frontiers in Cell and Developmental Biology

Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity

(2020) Johannes Burtscher et al.   iScience

Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19

(2020) Saima Ajaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response

(2020) Philippe Icard et al.   BIOCHIMIE

Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical

(2020) Xi Zhou et al.   BIOSCIENCE REPORTS

Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies

(2020) Mirko Cortese et al.   Cell Host & Microbe

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

(2020) Daniel J. Moreno Fernández-Ayala et al.   EXPERIMENTAL GERONTOLOGY

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

(2020) Peng Wang et al.   Cell Death & Disease

Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies

(2020) Jonathan P. Davies et al.   ACS Infectious Diseases

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity

(2020) Shen Li et al.   JCI Insight

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

Lipid droplet–membrane contact sites – from protein binding to function

(2019) Abdou Rachid Thiam et al.   JOURNAL OF CELL SCIENCE

Mitochondria in the biology, pathogenesis, and treatment of hepatitis virus infections

(2019) Changbo Qu et al.   REVIEWS IN MEDICAL VIROLOGY

Inhibitors of the mitochondrial calcium uniporter for the treatment of disease

(2019) Joshua J. Woods et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

G1P3 (IFI6), a mitochondrial localised antiapoptotic protein, promotes metastatic potential of breast cancer cells through mtROS

(2018) Venugopalan Cheriyath et al.   BRITISH JOURNAL OF CANCER

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy

(2018) Isaac Tamargo-Gómez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74–NF-κB signaling

(2018) Rudranil De et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute mental stress induces mitochondrial bioenergetic crisis and hyper-fission along with aberrant mitophagy in the gut mucosa in rodent model of stress-related mucosal disease

(2017) Rudranil De et al.   FREE RADICAL BIOLOGY AND MEDICINE

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

(2017) Masahiro Morita et al.   MOLECULAR CELL

Mitochondrial function, ornamentation, and immunocompetence

(2016) Rebecca E. Koch et al.   BIOLOGICAL REVIEWS

Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia

(2016) MASAAKI SHIDA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin

(2016) Huayqui Volt et al.   JOURNAL OF PINEAL RESEARCH

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

(2015) Masahiro Morita et al.   CELL CYCLE

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

(2015) Wei-ke Ji et al.   eLife

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

(2014) S. Bhattacharya et al.   EMBO Molecular Medicine

Mitochondrial hyperfusion promotes NF-κB activation via the mitochondrial E3 ligase MULAN

(2014) Naima Zemirli et al.   FEBS Journal

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Nonalcoholic Fatty Liver Disease, Diabetes Mellitus and Cardiovascular Disease: Newer Data

(2013) A. N. Mavrogiannaki et al.   International Journal of Endocrinology

Mitochondrial-mediated antiviral immunity

(2012) Takumi Koshiba   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus Pathogenesis

(2012) Ruth McBride et al.   Viruses-Basel

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation

(2011) Justine P. Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stomatin-Like Protein 2 Binds Cardiolipin and Regulates Mitochondrial Biogenesis and Function

(2011) D. A. Christie et al.   MOLECULAR AND CELLULAR BIOLOGY

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

(2010) Xin-Yi Liu et al.   CELL RESEARCH

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

(2009) Rinki Minakshi et al.   PLoS One

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL