Host metabolic reprogramming in response to SARS-CoV-2 infection: A systems biology approach

Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and Influenza virus

(2021) Einat.B. Vitner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 2019‐new coronavirus epidemic: Evidence for virus evolution

(2020) Domenico Benvenuto et al.   JOURNAL OF MEDICAL VIROLOGY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Mitochondrial Interactome: A Focus on Antiviral Signaling Pathways

(2020) Giulia Refolo et al.   Frontiers in Cell and Developmental Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

(2020) Bo Shen et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Cytosine drives evolution of SARS‐CoV‐2

(2020) Antoine Danchin et al.   ENVIRONMENTAL MICROBIOLOGY

Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID-19

(2020) Jahan S. Khalili et al.   JOURNAL OF MEDICAL VIROLOGY

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

(2020) Denisa Bojkova et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

(2020) Alexey Polonikov   ACS Infectious Diseases

Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response

(2020) Zhihua Ren et al.   Frontiers in Immunology

Diverse Functions of Polyamines in Virus Infection

(2020) Mason R. Firpo et al.   Biomolecules

Single-Cell Sequencing of Peripheral Mononuclear Cells Reveals Distinct Immune Response Landscapes of COVID-19 and Influenza Patients

(2020) Linnan Zhu et al.   IMMUNITY

Commentary: Phosphodiesterase 4 inhibitors as potential adjunct treatment targeting the cytokine storm in COVID-19

(2020) Maria Dalamaga et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting Leukotrienes

(2020) Colin D. Funk et al.   Frontiers in Pharmacology

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

(2020) Tiffany Thomas et al.   JCI Insight

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

signatureSearch: environment for gene expression signature searching and functional interpretation

(2020) Yuzhu Duan et al.   NUCLEIC ACIDS RESEARCH

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

(2020) Nicole A. P. Lieberman et al.   PLOS BIOLOGY

FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2

(2020) Alina Renz et al.   BIOINFORMATICS

The potential effectiveness of acetazolamide in the prevention of acute kidney injury in COVID-19: A hypothesis

(2020) Parham Habibzadeh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

(2020) Ruochen Zang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network

(2020) Hadrien Delattre et al.   Life Science Alliance

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

(2019) Bingpeng Yan et al.   Viruses-Basel

Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses

(2019) María Maximina B. Moreno-Altamirano et al.   Frontiers in Cellular and Infection Microbiology

Viral hijacking of cellular metabolism

(2019) Shivani K. Thaker et al.   BMC BIOLOGY

Glucose Metabolism Linked to Antiviral Responses

(2019) Joshua S. Stoolman et al.   CELL

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

(2019) Yuetong Wang et al.   Cell Reports

Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction

(2019) Katharina A. Mayer et al.   Frontiers in Immunology

Ribavirin Induces Polyamine Depletion via Nucleotide Depletion to Limit Virus Replication

(2019) Patrick M. Tate et al.   Cell Reports

Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication

(2019) Chen-Hsuin Lee et al.   mBio

A genome-wide positioning systems network algorithm for in silico drug repurposing

(2019) Feixiong Cheng et al.   Nature Communications

Recon3D enables a three-dimensional view of gene variation in human metabolism

(2018) Elizabeth Brunk et al.   NATURE BIOTECHNOLOGY

Interferons: Reprogramming the Metabolic Network against Viral Infection

(2018) Kavita Raniga et al.   Viruses-Basel

Network-based approach to prediction and population-based validation of in silico drug repurposing

(2018) Feixiong Cheng et al.   Nature Communications

A naturally occurring antiviral ribonucleotide encoded by the human genome

(2018) Anthony S. Gizzi et al.   NATURE

CMPK2 and BCL-G are associated with type 1 interferon–induced HIV restriction in humans

(2018) Ramy El-Diwany et al.   Science Advances

In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes

(2018) Jacqueline M. Ratter et al.   Frontiers in Immunology

Polyamines and Their Role in Virus Infection

(2017) Bryan C. Mounce et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity

(2017) Takuma Yoshizumi et al.   Scientific Reports

Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses

(2016) Bryan C. Mounce et al.   Cell Host & Microbe

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection

(2016) Kaartik Soota et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Lung epithelial NOX/DUOX and respiratory virus infections

(2015) Nathalie Grandvaux et al.   CLINICAL SCIENCE

Viral activation of cellular metabolism

(2015) Erica L. Sanchez et al.   VIROLOGY

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for Middle East Respiratory Syndrome Coronavirus Infection as Identified by Temporal Kinome Analysis

(2014) Jason Kindrachuk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

Impaired T cell function in argininosuccinate synthetase deficiency

(2014) Tatyana N. Tarasenko et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endogenous polyamine function—the RNA perspective

(2014) Helen L. Lightfoot et al.   NUCLEIC ACIDS RESEARCH

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

(2014) K M Dodd et al.   ONCOGENE

An Invertebrate Warburg Effect: A Shrimp Virus Achieves Successful Replication by Altering the Host Metabolome via the PI3K-Akt-mTOR Pathway

(2014) Mei-An Su et al.   PLoS Pathogens

Valine, the branched-chain amino acid, suppresses hepatitis C virus RNA replication but promotes infectious particle formation

(2013) Hisashi Ishida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response

(2013) Karin Fink et al.   CELL RESEARCH

Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20

(2013) Meng Xia et al.   IMMUNITY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection

(2013) S. L. Grady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus

(2013) D. Finkelshtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial-mediated antiviral immunity

(2012) Takumi Koshiba   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

The Battle over mTOR: An Emerging Theatre in Host–Pathogen Immunity

(2012) Sunil Martin et al.   PLoS Pathogens

MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles

(2012) Nicolas Menzel et al.   PLoS Pathogens

Dual Oxidase 2 is Essential for the Toll-Like Receptor 5-Mediated Inflammatory Response in Airway Mucosa

(2011) Jung-Hee Joo et al.   ANTIOXIDANTS & REDOX SIGNALING

Malnutrition Impairs Interferon Signaling Through mTOR and FoxO Pathways in Patients With Chronic Hepatitis C

(2011) Masao Honda et al.   GASTROENTEROLOGY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway

(2010) C. Jackel-Cram et al.   JOURNAL OF GENERAL VIROLOGY