Cytokine Storm—Definition, Causes, and Implications

Integrated view of molecular diagnosis and prognosis of dengue viral infection: future prospect of exosomes biomarkers

(2022) Rashmi Rana et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hyperinflammation, apoptosis, and organ damage

(2022) Frans A Kuypers   EXPERIMENTAL BIOLOGY AND MEDICINE

Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures

(2022) Roman A. Lukaszewski et al.   INTENSIVE CARE MEDICINE

Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis

(2022) Xuan Lu et al.   Frontiers in Immunology

Mortality Prediction in Sepsis With an Immune-Related Transcriptomics Signature: A Multi-Cohort Analysis

(2022) Louis Kreitmann et al.   Frontiers in Medicine

Distinguishing bacterial versus non-bacterial causes of febrile illness – A systematic review of host biomarkers

(2021) B. Leticia Fernandez-Carballo et al.   JOURNAL OF INFECTION

Cytokine Drizzle – The Rationale for Abandoning “Cytokine Storm”

(2021) Allan E. Stolarski et al.   SHOCK

Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies

(2021) Miquéias Lopes-Pacheco et al.   Frontiers in Physiology

Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock

(2021) Rainer König et al.   Frontiers in Immunology

Sepsis—Pathophysiology and Therapeutic Concepts

(2021) Dominik Jarczak et al.   Frontiers in Medicine

The Mechanism behind Influenza Virus Cytokine Storm

(2021) Yinuo Gu et al.   Viruses-Basel

Global epidemiology and changing clinical presentations of invasive meningococcal disease: a narrative review

(2021) Ala-Eddine Deghmane et al.   Infectious Diseases

The immunology of sepsis

(2021) Tom van der Poll et al.   IMMUNITY

Overview of Castleman Disease

(2020) Angela Dispenzieri et al.   BLOOD

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

Neutrophil extracellular trap formation and nuclease activity in septic patients

(2020) Linda E. Cox et al.   BMC Anesthesiology

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis

(2020) Chang Hwan Seol et al.   CYTOKINE

Multiorgan and Renal Tropism of SARS-CoV-2

(2020) Victor G. Puelles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia

(2020) Xanthe Brands et al.   Frontiers in Immunology

Severe immunosuppression and not a cytokine storm characterize COVID-19 infections

(2020) Kenneth E. Remy et al.   JCI Insight

SOS1 Gain of Function Variants in Dilated Cardiomyopathy

(2020) Jason R. Cowan et al.   Circulation-Genomic and Precision Medicine

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

(2020) Matthijs Kox et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Single Cell RNA-SEQ of Human Myeloid Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets with Unique Transcriptional Responses

(2020) Dijoia B. Darden et al.   SHOCK

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

(2020) Daniel E Leisman et al.   Lancet Respiratory Medicine

Cytokine “storm”, cytokine “breeze”, or both in COVID-19?

(2020) Giuseppe Lippi et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation

(2019) Toshiaki Iba et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Post-splenectomy sepsis: preventative strategies, challenges, and solutions

(2019) Sarah Luu et al.   Infection and Drug Resistance

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

(2019) Arsun Bektas et al.   Aging-US

Activation of immunosuppressive network in the aging process

(2019) Antero Salminen   AGEING RESEARCH REVIEWS

The earlier the better: timely mitigation of CRS

(2019) Rayne H. Rouce   BLOOD

Calprotectin is superior to procalcitonin as a sepsis marker and predictor of 30-day mortality in intensive care patients

(2019) Anders Larsson et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

The utility of presepsin in diagnosis and risk stratification for the emergency patients with sepsis

(2018) Bin Lu et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Tissue Factor

(2018) Steven P. Grover et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multicentric Standardized Flow Cytometry Routine Assessment of Patients With Sepsis to Predict Clinical Worsening

(2018) Thomas Daix et al.   CHEST

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases

(2018) J. Rello et al.   CLINICAL MICROBIOLOGY AND INFECTION

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters

(2018) Timothy E. Sweeney et al.   CRITICAL CARE MEDICINE

Inflammation and neutrophil immunosenescence in health and disease: Targeted treatments to improve clinical outcomes in the elderly

(2018) William Drew et al.   EXPERIMENTAL GERONTOLOGY

Compartment diversity in innate immune reprogramming

(2018) Orhan Rasid et al.   MICROBES AND INFECTION

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Procalcitonin and MR-Proadrenomedullin Combination with SOFA and qSOFA Scores for Sepsis Diagnosis and Prognosis

(2018) Silvia Spoto et al.   SHOCK

A rare case of septic shock due to Neisseria meningitidis serogroup B infection despite prior vaccination in a young adult with paroxysmal nocturnal haemoglobinuria receiving eculizumab

(2018) Dominik Reher et al.   VACCINE

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Interaction of the Human Contact System with Pathogens—An Update

(2018) Sonja Oehmcke-Hecht et al.   Frontiers in Immunology

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

The molecular details of cytokine signalling via the JAK/STAT pathway

(2018) Rhiannon Morris et al.   PROTEIN SCIENCE

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial

(2018) David B Antcliffe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ASBMT Consensus Grading for Cytokine Release Syndrome and Neurological Toxicity Associated with Immune Effector Cells

(2018) Daniel W Lee et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study

(2018) Manu Shankar-Hari et al.   INTENSIVE CARE MEDICINE

Interferon-Stimulated Genes as Enhancers of Antiviral Innate Immune Signaling

(2017) Keaton M. Crosse et al.   Journal of Innate Immunity

Advances in the understanding and treatment of sepsis-induced immunosuppression

(2017) Fabienne Venet et al.   Nature Reviews Nephrology

Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation

(2017) S. Denk et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

A Four-Biomarker Blood Signature Discriminates Systemic Inflammation Due to Viral Infection Versus Other Etiologies

(2017) D. L. Sampson et al.   Scientific Reports

Peripheral blood vessels are a niche for blood-borne meningococci

(2017) Elena Capel et al.   Virulence

Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity

(2017) David Andaluz-Ojeda et al.   Annals of Intensive Care

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

(2017) Brendon P Scicluna et al.   Lancet Respiratory Medicine

Chimeric antigen-receptor T-cell therapy for hematological malignancies and solid tumors: Clinical data to date, current limitations and perspectives

(2017) J. Gauthier et al.   Current Research in Translational Medicine

Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study

(2016) Thorsten Brenner et al.   BIOMARKERS

The Roles of Type I Interferon in Bacterial Infection

(2016) Gayle M. Boxx et al.   Cell Host & Microbe

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

(2016) Bita Shakoory et al.   CRITICAL CARE MEDICINE

The immune system's role in sepsis progression, resolution, and long-term outcome

(2016) Matthew J. Delano et al.   IMMUNOLOGICAL REVIEWS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A HeterozygousRAB27AMutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis

(2016) Mingce Zhang et al.   JOURNAL OF IMMUNOLOGY

Defining immunological dysfunction in sepsis: A requisite tool for precision medicine

(2016) Jesús F. Bermejo-Martin et al.   JOURNAL OF INFECTION

The Early Expression of HLA-DR and CD64 Myeloid Markers Is Specifically Compartmentalized in the Blood and Lungs of Patients with Septic Shock

(2016) Tomasz Skirecki et al.   MEDIATORS OF INFLAMMATION

Inflammatory markers following resuscitation from out-of-hospital cardiac arrest—A prospective multicenter observational study

(2016) Mary Ann Peberdy et al.   RESUSCITATION

Endothelial activation/injury and associations with severity of post-cardiac arrest syndrome and mortality after out-of-hospital cardiac arrest

(2016) John Bro-Jeppesen et al.   RESUSCITATION

Robust classification of bacterial and viral infections via integrated host gene expression diagnostics

(2016) Timothy E. Sweeney et al.   Science Translational Medicine

The Endothelium in Sepsis

(2016) Can Ince et al.   SHOCK

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Type I Interferons in Bacterial Infections: A Balancing Act

(2016) Pavel Kovarik et al.   Frontiers in Immunology

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

A review of the equine age-related changes in the immune system: Comparisons between human and equine aging, with focus on lung-specific immune-aging

(2015) S. Hansen et al.   AGEING RESEARCH REVIEWS

Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

(2015) Hector R. Wong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Usefulness of suPAR in the risk stratification of patients with sepsis admitted to the emergency department

(2015) Ivo Casagranda et al.   Internal and Emergency Medicine

Global incidence of serogroup B invasive meningococcal disease: a systematic review

(2015) Shruti Sridhar et al.   LANCET INFECTIOUS DISEASES

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

(2015) David L. Porter et al.   Science Translational Medicine

Low Titers of Serum Antibodies Inhibiting Hemagglutination Predict Fatal Fulminant Influenza A(H1N1) 2009 Infection

(2014) Amélie Guihot et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

(2014) M. V. Maus et al.   BLOOD

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

Effect of age and CMV on NK cell subpopulations

(2014) Carmen Campos et al.   EXPERIMENTAL GERONTOLOGY

Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs

(2014) Cecilia A. Hinojosa et al.   EXPERIMENTAL GERONTOLOGY

Sepsis: Current Dogma and New Perspectives

(2014) Clifford S. Deutschman et al.   IMMUNITY

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

(2014) Lijuan Xiong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Usefulness of presepsin (sCD14 subtype) measurements as a new marker for the diagnosis and prediction of disease severity of sepsis in the Korean population

(2014) Oh Joo Kweon et al.   JOURNAL OF CRITICAL CARE

The systemic immune response to trauma: an overview of pathophysiology and treatment

(2014) Janet M Lord et al.   LANCET

Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization

(2014) Sandra C Bernard et al.   NATURE MEDICINE

Reactivation of Multiple Viruses in Patients with Sepsis

(2014) Andrew H. Walton et al.   PLoS One

Invasive meningococcal disease: a disease of the endothelial cells

(2014) Mathieu Coureuil et al.   TRENDS IN MOLECULAR MEDICINE

An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation

(2014) Olga M. Pena et al.   EBioMedicine

Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8+ T cells and dendritic cells

(2013) C. E. Terrell et al.   BLOOD

An extended leukocyte differential count (16 types of circulating leukocytes) using the cytodiff flow cytometric system can provide informations for the discrimination of sepsis severity and prediction of outcome in sepsis patients

(2013) Sang Hyuk Park et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Interferon induction and function at the mucosal surface

(2013) Russell K. Durbin et al.   IMMUNOLOGICAL REVIEWS

Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer

(2013) Chris P. Verschoor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding

(2013) Kendra N. Iskander et al.   PHYSIOLOGICAL REVIEWS

Gene expression profiles in febrile children with defined viral and bacterial infection

(2013) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Procalcitonin after cardiac arrest – An indicator of severity of illness, ischemia-reperfusion injury and outcome

(2013) Martin Annborn et al.   RESUSCITATION

Pathogenesis of Meningococcemia

(2013) M. Coureuil et al.   Cold Spring Harbor Perspectives in Medicine

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity

(2012) Jon Hazeldine et al.   AGING CELL

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Host Cytokine Storm Is Associated With Disease Severity of Severe Fever With Thrombocytopenia Syndrome

(2012) Y. Sun et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Sialyl Residues Modulate LPS-Mediated Signaling through the Toll-Like Receptor 4 Complex

(2012) Chiguang Feng et al.   PLoS One

Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition

(2012) Ravi S. Keshari et al.   PLoS One

A NET Outcome

(2012) Thea Lu et al.   Frontiers in Immunology

The Pathogenesis of Sepsis

(2011) Deborah J. Stearns-Kurosawa et al.   Annual Review of Pathology-Mechanisms of Disease

Perforin is a critical physiologic regulator of T-cell activation

(2011) J. E. Lykens et al.   BLOOD

Review of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen: Prepared on behalf of the British Committee for Standards in Haematology by a Working Party of the Haemato-Oncology Task Force

(2011) John M. Davies et al.   BRITISH JOURNAL OF HAEMATOLOGY

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

Age-related changes in natural killer cell receptors from childhood through old age

(2011) Aline Almeida-Oliveira et al.   HUMAN IMMUNOLOGY

Splenectomy Associated Changes in IgM Memory B Cells in an Adult Spleen Registry Cohort

(2011) Paul U. Cameron et al.   PLoS One

Influenza virus assembly and budding

(2011) Jeremy S. Rossman et al.   VIROLOGY

Evidence That Lipopolisaccharide May Contribute to the Cytokine Storm and Cellular Activation in Patients with Visceral Leishmaniasis

(2011) Joanna R. Santos-Oliveira et al.   PLoS Neglected Tropical Diseases

Human NK cells display major phenotypic and functional changes over the life span

(2010) Magali Le Garff-Tavernier et al.   AGING CELL

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Three fatal cases of pandemic 2009 influenza A virus infection in Shenzhen are associated with cytokine storm

(2010) Xiao-Wen Cheng et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Coagulation and innate immune responses: can we view them separately?

(2009) M. Delvaeye et al.   BLOOD

Biomarkers of sepsis

(2009) John C. Marshall et al.   CRITICAL CARE MEDICINE

Sepsis, complement and the dysregulated inflammatory response

(2009) Peter A. Ward et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cardiac Function and the Proinflammatory Cytokine Response After Recovery From Cardiac Arrest in Swine

(2009) James T. Niemann et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Regional Variation in Out-of-Hospital Cardiac Arrest Incidence and Outcome

(2008) Graham Nichol   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of a Bacteriophage with Meningococcal Disease in Young Adults

(2008) Emmanuelle Bille et al.   PLoS One

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

(2008) M. Rosas-Ballina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication

(2008) Jerry P. Nolan et al.   RESUSCITATION