Robust classification of bacterial and viral infections via integrated host gene expression diagnostics

Responses to Bacteria, Virus, and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia

(2016) Clarissa Valim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Host gene expression classifiers diagnose acute respiratory illness etiology

(2016) Ephraim L. Tsalik et al.   Science Translational Medicine

Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis

(2016) Timothy E Sweeney et al.   Lancet Respiratory Medicine

A Molecular Biomarker to Diagnose Community-acquired Pneumonia on Intensive Care Unit Admission

(2015) Brendon P. Scicluna et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Comprehensive Validation of theFAIM3:PLAC8Ratio in Time-matched Public Gene Expression Data

(2015) Timothy E. Sweeney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses

(2015) Marta Andres-Terre et al.   IMMUNITY

The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease

(2015) Laura Conejero et al.   JOURNAL OF IMMUNOLOGY

Superiority of Transcriptional Profiling Over Procalcitonin for Distinguishing Bacterial From Viral Lower Respiratory Tract Infections in Hospitalized Adults

(2015) Nicolas M. Suarez et al.   JOURNAL OF INFECTIOUS DISEASES

Olfactomedin 4 Serves as a Marker for Disease Severity in Pediatric Respiratory Syncytial Virus (RSV) Infection

(2015) H. K. Brand et al.   PLoS One

A comprehensive time-course–based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set

(2015) Timothy E. Sweeney et al.   Science Translational Medicine

A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts

(2015) Leo McHugh et al.   PLOS MEDICINE

Time since Onset of Disease and Individual Clinical Markers Associate with Transcriptional Changes in Uncomplicated Dengue

(2015) Cornelia A. M. van de Weg et al.   PLoS Neglected Tropical Diseases

Host Transcriptional Response to Influenza and Other Acute Respiratory Viral Infections – A Prospective Cohort Study

(2015) Yijie Zhai et al.   PLoS Pathogens

A Novel Host-Proteome Signature for Distinguishing between Acute Bacterial and Viral Infections

(2015) Kfir Oved et al.   PLoS One

Dengue Virus Infection Induces Expansion of a CD14+CD16+ Monocyte Population that Stimulates Plasmablast Differentiation

(2014) Marcin Kwissa et al.   Cell Host & Microbe

Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour

(2014) Ricard Ferrer et al.   CRITICAL CARE MEDICINE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

(2014) M. N. Lee et al.   SCIENCE

Identification of a human neonatal immune-metabolic network associated with bacterial infection

(2014) Claire L. Smith et al.   Nature Communications

A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation

(2013) Purvesh Khatri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes

(2013) Jethro A. Herberg et al.   JOURNAL OF INFECTIOUS DISEASES

Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis

(2013) Christina Wacker et al.   LANCET INFECTIOUS DISEASES

Gene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans

(2013) Sun Hee Ahn et al.   PLoS One

Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers

(2013) Chloe I. Bloom et al.   PLoS One

Gene expression profiles in febrile children with defined viral and bacterial infection

(2013) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Host-Based RT-PCR Gene Expression Signature to Identify Acute Respiratory Viral Infection

(2013) A. K. Zaas et al.   Science Translational Medicine

Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection

(2013) Asuncion Mejias et al.   PLOS MEDICINE

Peripheral blood RNA gene expression profiling in patients with bacterial meningitis

(2013) Margit Lill et al.   Frontiers in Neuroscience

PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells

(2012) E. A. Federzoni et al.   BLOOD

Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children

(2012) Adam D Irwin et al.   BMC Medical Genomics

Plasticity and Virus Specificity of the Airway Epithelial Cell Immune Response during Respiratory Virus Infection

(2012) I. Ioannidis et al.   JOURNAL OF VIROLOGY

Transcriptome signature in young children with acute otitis media due to Streptococcus pneumoniae

(2012) Keyi Liu et al.   MICROBES AND INFECTION

The Gene Expression Analysis of Blood Reveals S100A11 and AQP9 as Potential Biomarkers of Infective Endocarditis

(2012) Franck Thuny et al.   PLoS One

Temporal Dynamics of the Transcriptional Response to Dengue Virus Infection in Nicaraguan Children

(2012) Stephen J. Popper et al.   PLoS Neglected Tropical Diseases

Characterization of early host responses in adults with dengue disease

(2011) Thomas Tolfvenstam et al.   BMC INFECTIOUS DISEASES

Procalcitonin as a Biomarker in Respiratory Tract Infection

(2011) David N. Gilbert   CLINICAL INFECTIOUS DISEASES

Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza

(2011) Jan-Erik Berdal et al.   JOURNAL OF INFECTION

Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection – A Meta-Analysis of Genomic Signatures in Circulating Leukocytes

(2011) Grant Parnell et al.   PLoS One

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans

(2009) Aimee K. Zaas et al.   Cell Host & Microbe

Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum*

(2009) Hector R. Wong et al.   CRITICAL CARE MEDICINE

Antibiotic Prescription Rates for Acute Respiratory Tract Infections in US Ambulatory Settings

(2009) Carlos G. Grijalva   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gene Transcript Abundance Profiles Distinguish Kawasaki Disease from Adenovirus Infection

(2009) Stephen J. Popper et al.   JOURNAL OF INFECTIOUS DISEASES

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

(2009) Hiroshi Ashida et al.   NATURE CELL BIOLOGY

Enhanced Monocyte Response and Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections

(2009) Monica I. Ardura et al.   PLoS One

Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis

(2009) Rungnapa Pankla et al.   GENOME BIOLOGY

Validating the genomic signature of pediatric septic shock

(2008) Natalie Cvijanovich et al.   PHYSIOLOGICAL GENOMICS