FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy

CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

(2022) Xinyu Ma et al.   CELL

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

(2022) Shireen A. Sarraf et al.   MOLECULAR CELL

Non-coding RNA suppresses FUS aggregation caused by mechanistic shear stress on pipetting in a sequence-dependent manner

(2021) Nesreen Hamad et al.   Scientific Reports

Reactive astrocytes facilitate vascular repair and remodeling after stroke

(2021) Michael R. Williamson et al.   Cell Reports

Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke

(2021) Qingxue Xu et al.   Journal of Neuroinflammation

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separation

(2021) Stefan Reber et al.   NUCLEIC ACIDS RESEARCH

Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics

(2021) Amir Ajoolabady et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy

(2021) Qiaoni Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Diagnostic and Prognostic Circulating MicroRNA in Acute Stroke: A Systematic and Bioinformatic Analysis of Current Evidence

(2021) Jorin Bejleri et al.   Journal of Stroke

Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy

(2021) Mustafa T Ardah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking

(2021) Iva Stojkovska et al.   NEURON

Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 with MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy

(2020) Jade Pham et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein transmission in neurodegenerative disease

(2020) Chao Peng et al.   Nature Reviews Neurology

Protein Aggregation in the Pathogenesis of Ischemic Stroke

(2020) Shusheng Wu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Stroke

(2020) Bruce C V Campbell et al.   LANCET

Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte

(2020) Min Liu et al.   Journal of Neuroinflammation

ALS Genetics: Gains, Losses, and Implications for Future Therapies

(2020) Garam Kim et al.   NEURON

RNA as the stone guest of protein aggregation

(2020) Alexandra Louka et al.   NUCLEIC ACIDS RESEARCH

The Autophagy–RNA Interplay: Degradation and Beyond

(2020) Marie H. Abildgaard et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke

(2020) Anja Nitzsche et al.   CIRCULATION RESEARCH

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

(2020) Shireen A. Sarraf et al.   MOLECULAR CELL

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis

(2020) Daniel Jutzi et al.   Nature Communications

Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke

(2019) Changbo Lu et al.   NEURAL PLASTICITY

A Metabonomics Investigation into the Therapeutic Effects of BuChang NaoXinTong Capsules on Reversing the Amino Acid-Protein Interaction Network of Cerebral Ischemia

(2019) Jing Xu et al.   Oxidative Medicine and Cellular Longevity

Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage

(2019) Shotaro Michinaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

(2019) Stefano Thellung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS

(2018) Shannon Rhoads et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Variant-specific and reciprocal Hsp40 functions in Hsp104-mediated prion elimination

(2018) Michael T. Astor et al.   MOLECULAR MICROBIOLOGY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Astrocyte activation and reactive gliosis—A new target in stroke?

(2018) Milos Pekny et al.   NEUROSCIENCE LETTERS

Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases

(2018) Mithilesh Kumar Jha et al.   PROGRESS IN NEUROBIOLOGY

Cerebral ischemia induces the aggregation of proteins linked to neurodegenerative diseases

(2018) Anja Kahl et al.   Scientific Reports

Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

(2018) Xiaosong He et al.   Journal of Neuroinflammation

Stroke target identification guided by astrocyte transcriptome analysis

(2018) Cordula Rakers et al.   GLIA

Ischaemic stroke

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Opening a New Time Window for Treatment of Stroke by Targeting HDAC2

(2017) Yu-Hui Lin et al.   JOURNAL OF NEUROSCIENCE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration

(2017) Daisuke Ito et al.   Science Translational Medicine

Combined Intravenous Thrombolysis and Thrombectomy vs Thrombectomy Alone for Acute Ischemic Stroke

(2017) Jonathan M. Coutinho et al.   JAMA Neurology

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

(2016) Minshu Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP

(2015) Yong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMO2/3 is Associated with Ubiquitinated Protein Aggregates in the Mouse Neocortex after Middle Cerebral Artery Occlusion

(2014) Karin Hochrainer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Guidelines for the Primary Prevention of Stroke

(2014) James F. Meschia et al.   STROKE

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

Autophagic cell death exists

(2012) Peter G.H. Clarke et al.   Autophagy

Neuroprotection for Ischaemic Stroke: Translation from the Bench to the Bedside

(2012) Brad A. Sutherland et al.   International Journal of Stroke

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

(2012) Maria Armakola et al.   NATURE GENETICS

Implications of the prion-related Q/N domains in TDP-43 and FUS

(2011) Maria Udan et al.   Prion

Expression of human FUS protein in Drosophila leads to progressive neurodegeneration

(2011) Yanbo Chen et al.   Protein & Cell

Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy

(2011) Kazuo Fushimi et al.   Protein & Cell

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

A new subtype of frontotemporal lobar degeneration with FUS pathology

(2009) M. Neumann et al.   BRAIN

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus

(2009) Min Chen et al.   JOURNAL OF NEUROCHEMISTRY

Plasticity during stroke recovery: from synapse to behaviour

(2009) Timothy H. Murphy et al.   NATURE REVIEWS NEUROSCIENCE

The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases

(2009) Hiroshi Doi et al.   NEUROSCIENCE RESEARCH

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE