Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy

Phase separation of Axin organizes the β-catenin destruction complex

(2021) Junxiu Nong et al.   JOURNAL OF CELL BIOLOGY

Nuclear Dishevelled targets gene regulatory regions and promotes tumor growth

(2021) Isabel Castro‐Piedras et al.   EMBO REPORTS

Wnts and the hallmarks of cancer

(2020) Zheng Zhong et al.   CANCER AND METASTASIS REVIEWS

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

(2020) Kristina N. Schaefer et al.   MOLECULAR BIOLOGY OF THE CELL

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

(2020) Wei Kan et al.   eLife

Autophagy negative-regulating Wnt signaling enhanced inflammatory osteoclastogenesis from Pre-OCs in vitro

(2020) Lili Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation

(2020) Wenzhe Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation

(2020) Tie-Mei Li et al.   Scientific Reports

Decoding Dishevelled-Mediated Wnt Signaling in Vertebrate Early Development

(2020) De-Li Shi   Frontiers in Cell and Developmental Biology

The involvement of noncanonical Wnt signaling in cancers

(2020) Yongfeng Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism

(2019) Xiawei Cheng et al.   MOLECULAR CELL

Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates

(2019) Kristina N. Schaefer et al.   DEVELOPMENTAL CELL

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1

(2019) Jakub Harnoš et al.   Nature Communications

Myoferlin Regulates Wnt/β-Catenin Signaling-Mediated Skeletal Muscle Development by Stabilizing Dishevelled-2 Against Autophagy

(2019) Shunshun Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancer

(2019) Monica Sharma et al.   Scientific Reports

Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs

(2019) Kateřina Hanáková et al.   Cell Communication and Signaling

Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers

(2018) Mireia Nàger et al.   Autophagy

Dishevelled: A masterful conductor of complex Wnt signals

(2018) Monica Sharma et al.   CELLULAR SIGNALLING

From instruction to output: Wnt/PCP signaling in development and cancer

(2018) Ashley Ceinwen Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

Multiprotein complexes governing Wnt signal transduction

(2018) Melissa Gammons et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt signalling: conquering complexity

(2018) Katrin E. Wiese et al.   DEVELOPMENT

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

PP5 (PPP5C) is a phosphatase of Dvl2

(2018) Jianlei Xie et al.   Scientific Reports

ULK1 negatively regulates Wnt signaling by phosphorylating Dishevelled

(2018) Sun-Hong Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy induction impairs Wnt/β-catenin signalling through β-catenin relocalisation in glioblastoma cells

(2018) Barbara Colella et al.   CELLULAR SIGNALLING

Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy

(2018) Kuo Zhang et al.   Nature Communications

DVL1 and DVL3 differentially localize to CYP19A1 promoters and regulate aromatase mRNA in breast cancer cells

(2018) Isabel Castro-Piedras et al.   Oncotarget

Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways

(2017) Jing Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/β-Catenin Signaling in Mammalian Cells

(2017) Petra Paclíková et al.   MOLECULAR AND CELLULAR BIOLOGY

Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine

(2017) Mira I. Pronobis et al.   MOLECULAR BIOLOGY OF THE CELL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors

(2017) Jiaming Fan et al.   Oncotarget

Identification of small-molecule compounds targeting the dishevelled PDZ domain by virtual screening and binding studies

(2016) Jiwon Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Receptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt Signaling

(2016) Minzhang Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay

(2016) Melissa V. Gammons et al.   JOURNAL OF CELL SCIENCE

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled

(2016) Melissa V. Gammons et al.   MOLECULAR CELL

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins

(2016) Igor Cervenka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of ER stress-induced autophagy by GSK3β-TIP60-ULK1 pathway

(2016) Tiejian Nie et al.   Cell Death & Disease

ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size

(2016) Rotem Kadir et al.   PLoS Genetics

Mutations in DVL1 Cause an Osteosclerotic Form of Robinow Syndrome

(2015) Kieran J. Bunn et al.   AMERICAN JOURNAL OF HUMAN GENETICS

WNT5A Inhibits Hepatocyte Proliferation and Concludes β-Catenin Signaling in Liver Regeneration

(2015) Jing Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus

(2015) Wenqi Wang et al.   DEVELOPMENTAL CELL

The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy

(2015) Benyu Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

(2015) Xiaomo Jiang et al.   MOLECULAR CELL

PTEN regulates cilia through Dishevelled

(2015) Iryna Shnitsar et al.   Nature Communications

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

(2015) Nicolas Aznar et al.   eLife

A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

(2015) Mira I Pronobis et al.   eLife

Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways

(2015) Ho-Jin Lee et al.   eLife

Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation

(2014) Benyu Ma et al.   CELL RESEARCH

Insulin Receptor Substrate 1/2 (IRS1/2) Regulates Wnt/β-Catenin Signaling through Blocking Autophagic Degradation of Dishevelled2

(2014) Yongtao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1ϵ and Frizzled5

(2014) Ondřej Bernatík et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex

(2014) Ezgi Kunttas-Tatli et al.   MOLECULAR BIOLOGY OF THE CELL

Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway

(2014) R. E. A. de Groot et al.   Science Signaling

Signalosome assembly by domains undergoing dynamic head-to-tail polymerization

(2014) Mariann Bienz   TRENDS IN BIOCHEMICAL SCIENCES

Hipk2 and PP1c Cooperate to Maintain Dvl Protein Levels Required for Wnt Signal Transduction

(2014) Nobuyuki Shimizu et al.   Cell Reports

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

(2013) Katy J Petherick et al.   EMBO JOURNAL

HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation

(2013) Yi Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling

(2013) José M. González-Sancho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

(2013) H Jung et al.   Oncogenesis

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Delicate Analysis of Post-Translational Modifications on Dishevelled 3

(2012) Chaochao Wu et al.   JOURNAL OF PROTEOME RESEARCH

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

Wnt/ -catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

(2012) D. V. F. Tauriello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility

(2012) Maki Ishida-Takagishi et al.   Nature Communications

Dishevelled C-terminus: prolyl and histidinyl motifs

(2011) H.-Y. Wang et al.   Acta Physiologica

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway

(2011) Yanquan Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sequential Activation and Inactivation of Dishevelled in the Wnt/β-Catenin Pathway by Casein Kinases

(2011) Ondrej Bernatik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

(2011) Marc Fiedler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

(2011) C. Mendoza-Topaz et al.   Open Biology

PDZ domains and their binding partners: structure, specificity, and modification

(2010) Ho-Jin Lee et al.   Cell Communication and Signaling

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2

(2010) Florian Witte et al.   FASEB JOURNAL

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

(2010) K. R. Holloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases

(2009) Masahiro Narimatsu et al.   CELL

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled

(2009) David Grandy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ciliary polarity by the APC/C

(2009) A. Ganner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural and functional determinants of the Axin and Dishevelled DIX domains

(2009) Matthias T Ehebauer et al.   BMC STRUCTURAL BIOLOGY

Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction

(2008) Xiao-qing Gan et al.   JOURNAL OF CELL BIOLOGY

Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development

(2008) S. Leah Etheridge et al.   PLoS Genetics

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

(2007) Yi-Nan Lee et al.   CELLULAR SIGNALLING