Variant-specific and reciprocal Hsp40 functions in Hsp104-mediated prion elimination

Curing of [PSI+] by Hsp104 Overexpression: Clues to solving the puzzle

(2018) Lois E. Greene et al.   Prion

Chaperone functional specificity promotes yeast prion diversity

(2018) Andrea N. Killian et al.   PLoS Pathogens

Heat shock protein 104 (Hsp104)-mediated curing of [PSI+] yeast prions depends on both [PSI+] conformation and the properties of the Hsp104 homologs

(2017) Xiaohong Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

To CURe or not to CURe? Differential effects of the chaperone sorting factor Cur1 on yeast prions are mediated by the chaperone Sis1

(2017) Yury A. Barbitoff et al.   MOLECULAR MICROBIOLOGY

Over-expression of the molecular chaperone Hsp104 inSaccharomyces cerevisiaeresults in the malpartition of [PSI+] propagons

(2017) Frederique Ness et al.   MOLECULAR MICROBIOLOGY

Prion-specific Hsp40 function: The role of the auxilin homolog Swa2

(2017) Emily E. Oliver et al.   Prion

Hsp104 disaggregase at normal levels cures many [PSI+] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p

(2017) Anton Gorkovskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Do J-Proteins Get Hsp70 to Do So Many Different Things?

(2017) Elizabeth A. Craig et al.   TRENDS IN BIOCHEMICAL SCIENCES

Broadening the functionality of a J-protein/Hsp70 molecular chaperone system

(2017) Brenda A. Schilke et al.   PLoS Genetics

Swa2, the yeast homolog of mammalian auxilin, is specifically required for the propagation of the prion variant [URE3-1]

(2015) Elizabeth M. Troisi et al.   MOLECULAR MICROBIOLOGY

Hsp40 function in yeast prion propagation: Amyloid diversity necessitates chaperone functional complexity

(2015) Zachary A Sporn et al.   Prion

Hsp90-Associated Immunophilin Homolog Cpr7 Is Required for the Mitotic Stability of [URE3] Prion in Saccharomyces cerevisiae

(2015) Navinder Kumar et al.   PLoS Genetics

Distinct Prion Strains Are Defined by Amyloid Core Structure and Chaperone Binding Site Dynamics

(2014) Kendra K. Frederick et al.   CHEMISTRY & BIOLOGY

Hsp104 Overexpression Cures Saccharomyces cerevisiae [ PSI + ] by Causing Dissolution of the Prion Seeds

(2014) Yang-Nim Park et al.   EUKARYOTIC CELL

Functional Diversification of Hsp40: Distinct J-Protein Functional Requirements for Two Prions Allow for Chaperone-Dependent Prion Selection

(2014) Julia M. Harris et al.   PLoS Genetics

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines

(2014) Michael Reidy et al.   PLoS Genetics

Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic Regions

(2014) Kevin C. Stein et al.   PLoS Genetics

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

Heritable Remodeling of Yeast Multicellularity by an Environmentally Responsive Prion

(2013) Daniel L. Holmes et al.   CELL

Sequential Duplications of an Ancient Member of the DnaJ-Family Expanded the Functional Chaperone Network in the Eukaryotic Cytosol

(2013) Chandan Sahi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Heterologous Gln/Asn-Rich Proteins Impede the Propagation of Yeast Prions by Altering Chaperone Availability

(2013) Zi Yang et al.   PLoS Genetics

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

Regulation of Chaperone Effects on a Yeast Prion by Cochaperone Sgt2

(2012) D. A. Kiktev et al.   MOLECULAR AND CELLULAR BIOLOGY

Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones

(2012) Anne T. Gillies et al.   Molecular BioSystems

Differences in the Curing of [PSI+] Prion by Various Methods of Hsp104 Inactivation

(2012) Yang-Nim Park et al.   PLoS One

Influence of prion variant and yeast strain variation on prion-molecular chaperone requirements

(2012) Justin K. Hines et al.   Prion

A new perspective on Hsp104-mediated propagation and curing of the yeast prion [PSI+]

(2012) Christopher W. Helsen et al.   Prion

Molecular Chaperone Hsp104 Can Promote Yeast Prion Generation

(2011) Dmitry S. Kryndushkin et al.   GENETICS

Functions of Yeast Hsp40 Chaperone Sis1p Dispensable for Prion Propagation but Important for Prion Curing and Protection From Prion Toxicity

(2011) P. Aaron Kirkland et al.   GENETICS

Insight into Molecular Basis of Curing of [PSI+] Prion by Overexpression of 104-kDa Heat Shock Protein (Hsp104)

(2011) Christopher W. Helsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Destabilization and Recovery of a Yeast Prion after Mild Heat Shock

(2011) Gary P. Newnam et al.   JOURNAL OF MOLECULAR BIOLOGY

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

The sensitive [SWI+] prion

(2011) Justin K. Hines et al.   Prion

[SWI+], the Prion Formed by the Chromatin Remodeling Factor Swi1, Is Highly Sensitive to Alterations in Hsp70 Chaperone System Activity

(2011) Justin K. Hines et al.   PLoS Genetics

Applying Hsp104 to protein-misfolding disordersThis paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.

(2010) Shilpa Vashist et al.   Biochemistry and Cell Biology

[NSI +]: a novel non-Mendelian nonsense suppressor determinant in Saccharomyces cerevisiae

(2010) Alsu F. Saifitdinova et al.   CURRENT GENETICS

Sti1 Regulation of Hsp70 and Hsp90 Is Critical for Curing of Saccharomyces cerevisiae [PSI+] Prions by Hsp104

(2010) M. Reidy et al.   MOLECULAR AND CELLULAR BIOLOGY

SUMOylation of the GTPase Rac1 is required for optimal cell migration

(2010) Sonia Castillo-Lluva et al.   NATURE CELL BIOLOGY

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Yeast AAA+ Chaperone Hsp104 Is Part of a Network That Links the Actin Cytoskeleton with the Inheritance of Damaged Proteins

(2009) P. Tessarz et al.   MOLECULAR AND CELLULAR BIOLOGY

The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

(2009) Basant K. Patel et al.   NATURE CELL BIOLOGY

Curing of Yeast [URE3] Prion by the Hsp40 Cochaperone Ydj1p Is Mediated by Hsp70

(2008) D. Sharma et al.   GENETICS

Variant-specific [PSI+] Infection Is Transmitted by Sup35 Polymers within [PSI+] Aggregates with Heterogeneous Protein Composition

(2008) Sviatoslav N. Bagriantsev et al.   MOLECULAR BIOLOGY OF THE CELL

In Vivo Monitoring of the Prion Replication Cycle Reveals a Critical Role for Sis1 in Delivering Substrates to Hsp104

(2008) Kimberly A. Tipton et al.   MOLECULAR CELL

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae

(2008) Zhiqiang Du et al.   NATURE GENETICS

Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments

(2008) Tobias Haslberger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Specificity of the J-protein Sis1 in the propagation of 3 yeast prions

(2008) T. Higurashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA