Recent insight into the role and therapeutic potential of YAP/TAZ in gastrointestinal cancers

YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

(2022) Miju Kim et al.   DEVELOPMENTAL CELL

TAZ promotes vasculogenic mimicry in gastric cancer through the upregulation of TEAD4

(2022) Yanhui Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction

(2022) Yuhan Chang et al.   Cell Reports

Identification of Small-molecule YAP-TEAD inhibitors by High-throughput docking for the Treatment of colorectal cancer

(2022) Lijun Li et al.   BIOORGANIC CHEMISTRY

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

(2022) Maria C. Heinz et al.   CANCER RESEARCH

USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer

(2022) Zhen Liu et al.   ONCOGENE

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

YAP promotes the proliferation and migration of colorectal cancer cells through the Glut3/AMPK signaling pathway

(2021) Linhua Jiang et al.   Oncology Letters

YAP promotes sorafenib resistance in hepatocellular carcinoma by upregulating survivin

(2021) Ting Sun et al.   CELLULAR ONCOLOGY

Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma

(2021) Tracy T. Tang et al.   MOLECULAR CANCER THERAPEUTICS

VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal squamous cell carcinoma cancer phenotype

(2021) McKayla Mickle et al.   MOLECULAR CARCINOGENESIS

YAP inhibits autophagy and promotes progression of colorectal cancer via upregulating Bcl-2 expression

(2021) Lan Jin et al.   Cell Death & Disease

YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior

(2021) Youngsic Jeon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

YAP/TAZ Suppress Drug Penetration Into Hepatocellular Carcinoma Through Stromal Activation

(2021) Kyungjoo Cho et al.   HEPATOLOGY

Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma

(2021) Li Liu et al.   MEDICINE

Radiation-induced YAP activation confers glioma radioresistance via promoting FGF2 transcription and DNA damage repair

(2021) Yu Zhang et al.   ONCOGENE

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53

(2021) Julian Heuberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of YAP1 by N6-methyladenosine-modified CircCPSF6 Drives Malignancy in Hepatocellular Carcinoma

(2021) Yunhao Chen et al.   CANCER RESEARCH

YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

(2021) Ruize Gao et al.   EMBO Molecular Medicine

CAF promotes chemoresistance through NRP2 in gastric cancer

(2021) Yanpeng Yang et al.   Gastric Cancer

TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis

(2021) Xiaobo Wang et al.   JOURNAL OF HEPATOLOGY

The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer

(2021) Mengjie Li et al.   ONCOGENE

STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis

(2021) Ying Shen et al.   Science Signaling

Hippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop

(2021) Yan Ding et al.   Cell Death & Disease

ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation

(2021) Yan Gu et al.   Nature Communications

Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis

(2021) Yuchen Liu et al.   JOURNAL OF HEPATOLOGY

Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis

(2020) Dandan Zhao et al.   Cancer Cell International

Gli1 interacts with YAP1 to promote tumorigenesis in esophageal squamous cell carcinoma

(2020) Chongchong Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation

(2020) Handong Ma et al.   Cell Reports

USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ

(2020) Hong Zhu et al.   CANCER RESEARCH

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

(2020) Qi Li et al.   Cell Stem Cell

YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

(2020) Jaffer A Ajani et al.   GUT

CDK5 activates Hippo signaling to confer resistance to radiotherapy via upregulating TAZ in lung cancer

(2020) Yulan Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway

(2020) Liwei An et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

(2020) Shumei Song et al.   Molecular Oncology

TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ

(2020) Sha Zhou et al.   ONCOGENE

Sitagliptin affects gastric cancer cells proliferation by suppressing Melanoma-associated antigen-A3 expression through Yes-associated protein inactivation

(2020) Qi Wang et al.   Cancer Medicine

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer

(2020) Yang Tang et al.   CANCER CELL

Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

(2020) Priscilla Cheung et al.   Cell Stem Cell

Cisplatin promotes the expression level of PD-L1 in the microenvironment of hepatocellular carcinoma through YAP1

(2020) Shenghao Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

(2020) Jeffrey K. Holden et al.   Cell Reports

YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice

(2020) Jaeoh Park et al.   CANCER RESEARCH

Thymine DNA glycosylase‐regulated TAZ promotes radioresistance by targeting nonhomologous end joining and tumor progression in esophageal cancer

(2020) Wei Zhou et al.   CANCER SCIENCE

Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway

(2020) Jian Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase

(2020) Qing Li et al.   GASTROENTEROLOGY

Knockdown of TAZ decrease the cancer stem properties of ESCC cell line YM-1 by modulation of Nanog, OCT-4 and SOX2

(2020) Ayyoob Khosravi et al.   GENE

Porphyromonas gingivalis promotes progression of esophageal squamous cell cancer via TGFβ-dependent Smad/YAP/TAZ signaling

(2020) Yi-Jun Qi et al.   PLOS BIOLOGY

SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1

(2020) Cong Tian et al.   Cancer Cell International

Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma

(2020) Xiaobing Miao et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2

(2020) Xia Chen et al.   Oxidative Medicine and Cellular Longevity

Obesity Potentiates Esophageal Squamous Cell Carcinoma Growth and Invasion by AMPK-YAP Pathway

(2020) Jia-Huang Liu et al.   Journal of Immunology Research

Anti-proliferative and anti-migratory effects of a novel YAP-TEAD interaction inhibitor identified using in silico molecular docking

(2019) Sarah Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

(2019) Nicola Ferrari et al.   Nature Communications

Yes-associated protein promotes cell migration via activating Wiskott-Aldrich syndrome protein family member 1 in oral squamous cell carcinoma

(2019) Lei Qi et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Gluconeogenesis in cancer cells – Repurposing of a starvation-induced metabolic pathway?

(2019) Gabriele Grasmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway

(2019) Yuan Zhou et al.   Cancer Cell International

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells

(2019) Paul Dent et al.   ONCOGENE

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice

(2019) Fang Hao et al.   PLoS One

A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma

(2019) Jun Liu et al.   Cell Death & Disease

FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway

(2019) Yeo et al.   Cancers

EphA2‐to‐YAP pathway drives gastric cancer growth and therapy resistance

(2019) Changhao Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Verteporfin targeting YAP1/TAZ‐TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells

(2019) Julie Giraud et al.   INTERNATIONAL JOURNAL OF CANCER

Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness

(2019) Lirong Zhang et al.   Cell Death & Disease

The YAP1–NMU Axis Is Associated with Pancreatic Cancer Progression and Poor Outcome: Identification of a Novel Diagnostic Biomarker and Therapeutic Target

(2019) Yoo et al.   Cancers

A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

(2019) Shigekazu Murakami et al.   DEVELOPMENTAL CELL

The YAP1 signaling inhibitors, verteporfin and CA3, suppress the mesothelioma cancer stem cell phenotype

(2019) Sivaveera Kandasamy et al.   MOLECULAR CANCER RESEARCH

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

(2019) Iván M. Moya et al.   SCIENCE

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

(2019) Haisheng Zhang et al.   Cancer Discovery

LINC01413/hnRNP-K/ZEB1 axis accelerates cell proliferation and epithelial-mesenchymal transition in colorectal cancer via inducing YAP1/TAZ1 translocation

(2019) Ling Ji et al.   Molecular Therapy-Nucleic Acids

lncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP

(2019) Nan Li et al.   CLINICAL CANCER RESEARCH

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors

(2019) Wenchao Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SHARPIN Inhibits Esophageal Squamous Cell Carcinoma Progression by Modulating Hippo Signaling

(2019) Aijia Zhang et al.   NEOPLASIA

Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans

(2018) Shanshan Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity

(2018) Xuesong Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

Yes-associated protein enhances proliferation and attenuates sensitivity to cisplatin in human gastric cancer cells

(2018) Ting Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

YAP/TAZ initiates gastric tumorigenesis via upregulation of MYC

(2018) Wonyoung Choi et al.   CANCER RESEARCH

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

(2018) Helena J. Janse van Rensburg et al.   CANCER RESEARCH

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial CellsNovelty and Significance

(2018) Jinlong He et al.   CIRCULATION RESEARCH

Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells

(2018) Chih‐Sheng Yang et al.   EMBO REPORTS

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions

(2018) Zhengdong Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma

(2018) Jingya Sun et al.   Theranostics

YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma

(2018) Min Hwan Kim et al.   Cancer Immunology Research

YAP/TAZ Activation as a Target for Treating Metastatic Cancer

(2018) Janine Warren et al.   Cancers

Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells

(2018) Fengbo Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

(2018) Sebastian Mueller et al.   NATURE

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors

(2018) Thijs J. Hagenbeek et al.   Science Signaling

miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression

(2018) Minjiang Chen et al.   EBioMedicine

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling

(2018) Noboru Ideno et al.   GASTROENTEROLOGY

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis

(2018) John M. Lamar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unbalanced YAP–SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma

(2018) Lianghai Wang et al.   ONCOGENE

FOXC2 positively regulates YAP signaling and promotes the glycolysis of nasopharyngeal carcinoma

(2017) Lijuan Song et al.   EXPERIMENTAL CELL RESEARCH

Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice

(2017) Han-Byul Kim et al.   GASTROENTEROLOGY

Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma

(2017) Wantae Kim et al.   GUT

YAP suppresses gluconeogenic gene expression through PGC1α

(2017) Yue Hu et al.   HEPATOLOGY

TAZ overexpression is associated with epithelial-mesenchymal transition in cisplatin-resistant gastric cancer cells

(2017) Liang Ge et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression

(2017) Zhaoji Pan et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Expression of a hepatitis B virus pre-S2 deletion mutant in the liver results in hepatomegaly and hepatocellular carcinoma in mice

(2017) Yuan-Chi Teng et al.   JOURNAL OF PATHOLOGY

A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma

(2017) Shumei Song et al.   MOLECULAR CANCER THERAPEUTICS

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

(2017) J Feng et al.   ONCOGENE

YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis

(2017) Koji Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual roles of yes-associated protein (YAP) in colorectal cancer

(2017) Chunlin Ou et al.   Oncotarget

YAP regulates PD-L1 expression in human NSCLC cells

(2017) Jinbai Miao et al.   Oncotarget

TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration

(2017) Y Gao et al.   Oncogenesis

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

(2016) Ralph Gruber et al.   GASTROENTEROLOGY

Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma

(2016) Takaaki Higashi et al.   MEDICAL ONCOLOGY

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

(2016) Andrew G. Cox et al.   NATURE CELL BIOLOGY

Combine and conquer: challenges for targeted therapy combinations in early phase trials

(2016) Juanita S. Lopez et al.   Nature Reviews Clinical Oncology

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma

(2016) S Murakami et al.   ONCOGENE

Metformin mediates resensitivity to 5-fluorouracil in hepatocellular carcinoma via the suppression of YAP

(2016) Yu Tian et al.   Oncotarget

An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression

(2015) H. Hayashi et al.   CANCER RESEARCH

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

(2015) S. Song et al.   CLINICAL CANCER RESEARCH

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

(2015) Yun-Yong Park et al.   HEPATOLOGY

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells

(2015) YANLI YUAN et al.   Molecular Medicine Reports

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

RUNX3 is a novel negative regulator of oncogenic TEAD–YAP complex in gastric cancer

(2015) Y Qiao et al.   ONCOGENE

YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage

(2015) E Ciamporcero et al.   ONCOGENE

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

(2015) Ajaybabu V. Pobbati et al.   STRUCTURE

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

(2015) Tackhoon Kim et al.   Nature Communications

Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells

(2015) Upal Basu-Roy et al.   Nature Communications

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

(2015) G. Wang et al.   Cancer Discovery

Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression

(2015) Dacheng Xie et al.   Oncotarget

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells

(2015) Cristian Taccioli et al.   Oncotarget

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

(2015) Shuping Yang et al.   Oncotarget

Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

(2015) Yusuke Oku et al.   FEBS Open Bio

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties

(2014) S. Song et al.   CANCER RESEARCH

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

(2014) Avnish Kapoor et al.   CELL

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

(2014) Francesca Cottini et al.   NATURE MEDICINE

Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration

(2014) W Mi et al.   ONCOGENE

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

(2014) M Bartucci et al.   ONCOGENE

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

(2014) W. Zhang et al.   Science Signaling

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

(2014) Zhisen Zhang et al.   ACS Medicinal Chemistry Letters

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

A novel panel of biomarkers predicts radioresistance in patients with squamous cell carcinoma of the head and neck

(2013) Jan Akervall et al.   EUROPEAN JOURNAL OF CANCER

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Simvastatin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer

(2013) Volker Fendrich et al.   PANCREATOLOGY

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Hepatitis B virus X protein modulates oncogene yes-associated protein by CREB to promote growth of hepatoma cells

(2012) Tao Zhang et al.   HEPATOLOGY

Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice

(2012) Altaf Mohammed et al.   INTERNATIONAL JOURNAL OF CANCER

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Hippo signaling inDrosophila: Recent advances and insights

(2011) Binnaz Kucuk Staley et al.   DEVELOPMENTAL DYNAMICS

Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation

(2011) A Fernandez-L et al.   ONCOGENE

Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP

(2010) A. M. Vigneron et al.   GENES & DEVELOPMENT

YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets

(2010) R Ehsanian et al.   ONCOGENE

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Yes-associated protein (YAP) functions as a tumor suppressor in breast

(2008) M Yuan et al.   CELL DEATH AND DIFFERENTIATION

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL