YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines

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USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis

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Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study

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High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes

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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

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A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

(2019) Wen-Hsuan Yang et al.   MOLECULAR CANCER RESEARCH

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

(2019) Fengyuan Tang et al.   Nature Communications

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

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YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

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ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization

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HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models

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Hepatocellular carcinoma

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma

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Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition

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Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

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STAR: ultrafast universal RNA-seq aligner

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Cutoff Finder: A Comprehensive and Straightforward Web Application Enabling Rapid Biomarker Cutoff Optimization

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Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis

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Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of rapamycin (mTOR)-dependent survivin expression

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Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

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The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Sorafenib in Advanced Hepatocellular Carcinoma

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