Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-06-09
DOI
10.3389/fonc.2022.894744
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Patients with low nicotinamide N-methyltransferase expression benefit significantly from bevacizumab treatment in ovarian cancer
- (2021) Jun Li et al. BMC CANCER
- High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer’s Disease
- (2021) Altin Kocinaj et al. MOLECULAR NEUROBIOLOGY
- 1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer
- (2021) Marisa K. Kilgour et al. Science Advances
- Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders
- (2021) Aimo Kannt et al. MOLECULES
- Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020
- (2021) Wei Cao et al. CHINESE MEDICAL JOURNAL
- Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer
- (2021) Renata Novak Kujundžić et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Nicotinamide N‐Methyltransferase Gene Silencing Enhances Chemosensitivity of Melanoma Cell Lines
- (2021) Roberto Campagna et al. Pigment Cell & Melanoma Research
- TTPAL promotes gastric tumorigenesis by directly targeting NNMT to activate PI3K/AKT signaling
- (2021) Wenxiu Liu et al. ONCOGENE
- Protein-protein interactions involving enzymes of the mammalian methionine and homocysteine metabolism
- (2020) Francisco Portillo et al. BIOCHIMIE
- Crosstalk between autophagy and metabolic regulation of cancer stem cells
- (2020) Mouradi El Hout et al. Molecular Cancer
- High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer
- (2020) Mengmeng Song et al. Cancer Medicine
- Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells
- (2020) Haitao Yu et al. Cancer Cell International
- Epigenetic Attire in Ovarian Cancer: The Emperor's New Clothes
- (2020) Daniela Matei et al. CANCER RESEARCH
- Cancer stem cell enrichment is associated with enhancement of nicotinamide N‐methyltransferase expression
- (2020) Valentina Pozzi et al. IUBMB LIFE
- ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development
- (2020) Qing Song et al. JOURNAL OF HEPATOLOGY
- Nicotinamide N-methyltransferase overexpression may be associated with poor prognosis in ovarian cancer
- (2020) İsmail Harmankaya et al. JOURNAL OF OBSTETRICS AND GYNAECOLOGY
- Nicotinamide N‐methyltransferase decreases 5‐fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect
- (2020) Yanyan Cui et al. MOLECULAR CARCINOGENESIS
- Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient
- (2020) Hye Won Lee et al. Genome Medicine
- The Molecular Link from Diet to Cancer Cell Metabolism
- (2020) Shree Bose et al. MOLECULAR CELL
- Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase
- (2020) Iredia D. Iyamu et al. ANALYTICAL BIOCHEMISTRY
- Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N‐methyltransferase level in endothelial cells
- (2020) Dorota Dymkowska et al. JOURNAL OF APPLIED TOXICOLOGY
- Drug repurposing for cancer treatments: a well-intentioned, but misguided strategy
- (2020) Audrey A Tran et al. LANCET ONCOLOGY
- Accumulation of Nicotinamide N-Methyltransferase (NNMT) in Cancer-associated Fibroblasts: A Potential Prognostic and Predictive Biomarker for Gastric Carcinoma
- (2020) Li Zhang et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Nicotinamide Overcomes Doxorubicin Resistance of Breast Cancer Cells through Deregulating SIRT1/Akt Pathway
- (2019) Yingze Wei et al. Anti-Cancer Agents in Medicinal Chemistry
- Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase
- (2019) Sudeshna Sen et al. ACS Chemical Biology
- Expression and Clinical Significance of Nicotinamide N-Methyltransferase in Cervical Squamous Cell Carcinoma
- (2019) Serra Akar et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
- Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
- (2019) Mark A. Eckert et al. NATURE
- Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity
- (2019) Yongzhi Gao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform
- (2019) Jie Li et al. Molecular Oncology
- Connections between metabolism and epigenetics in cancers
- (2019) Chitra Thakur et al. SEMINARS IN CANCER BIOLOGY
- Nicotinamide N-Methyltransferase and Its Precursor Substrate Methionine Directly and Indirectly Control Malignant Metabolism During Progression of Renal Cell Carcinoma
- (2019) SINA HOLSTEIN et al. ANTICANCER RESEARCH
- The emergence of drug resistance to targeted therapies: Clinical evidence
- (2019) Ana Bela Sarmento-Ribeiro et al. DRUG RESISTANCE UPDATES
- Nicotinamide N‑methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells
- (2019) Young‑Sool Hah et al. ONCOLOGY REPORTS
- BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents
- (2019) Arun Kanakkanthara et al. CANCER RESEARCH
- High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)
- (2019) Rocco L. Policarpo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N-Methyltransferase
- (2019) Dongxing Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
- (2018) Harshini Neelakantan et al. BIOCHEMICAL PHARMACOLOGY
- Covalent inhibitors of nicotinamide N -methyltransferase (NNMT) provide evidence for target engagement challenges in situ
- (2018) Hsin-Yu Lee et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Organoids: An intermediate modeling platform in precision oncology
- (2018) Ming-Zhu Jin et al. CANCER LETTERS
- Functions of autophagy in the tumor microenvironment and cancer metastasis
- (2018) Erin E. Mowers et al. FEBS Journal
- Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)
- (2018) Nicolas Babault et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nicotinamide N-methyltransferase
- (2018) Giulia Ganzetti et al. MELANOMA RESEARCH
- NNMT activation can contribute to the development of fatty liver disease by modulating the NAD+ metabolism
- (2018) Motoaki Komatsu et al. Scientific Reports
- A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
- (2018) Aimo Kannt et al. Scientific Reports
- Targeting Nicotinamide N -Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells
- (2018) Duc-Hiep Bach et al. Molecular Therapy-Nucleic Acids
- Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism
- (2018) Shangyu Hong et al. BIOCHEMISTRY
- NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation
- (2018) Ji Hye Shin et al. Oncogenesis
- Targeting the interplay between metabolism and epigenetics in cancer
- (2018) Emilie Montellier et al. CURRENT OPINION IN ONCOLOGY
- NAD Metabolism in Cancer Therapeutics
- (2018) Keisuke Yaku et al. Frontiers in Oncology
- Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase
- (2017) Harshini Neelakantan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells
- (2017) Catharina Melzer et al. Molecular Cancer
- The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
- (2017) Arnab Ray Chaudhuri et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours
- (2017) G Itoh et al. ONCOGENE
- Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state
- (2017) Matthijs J. van Haren et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Nicotinamide N -Methyltransferase: More Than a Vitamin B3 Clearance Enzyme
- (2017) Pavlos Pissios TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT
- (2017) Justyna Kanska et al. Oncotarget
- A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo
- (2016) Christopher G. Hubert et al. CANCER RESEARCH
- NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability
- (2016) Kamalakannan Palanichamy et al. CLINICAL CANCER RESEARCH
- Proteomics identification of PGAM1 as a potential therapeutic target for urothelial bladder cancer
- (2016) X.C. Peng et al. Journal of Proteomics
- Chemical Proteomic Profiling of Human Methyltransferases
- (2016) Benjamin D. Horning et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Expression profile and prognostic value of NNMT in patients with pancreatic cancer
- (2016) Yong Xu et al. Oncotarget
- Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway
- (2016) Xinyou Xie et al. Oncotarget
- NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
- (2015) Carles Cantó et al. Cell Metabolism
- Effects of Nicotinamide N-Methyltransferase on PANC-1 Cells Proliferation, Metastatic Potential and Survival Under Metabolic Stress
- (2015) Tao Yu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
- (2015) Shangyu Hong et al. NATURE MEDICINE
- Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells
- (2014) Xinyou Xie et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells
- (2014) Wen-jian Lin et al. Autophagy
- Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
- (2014) Daniel Kraus et al. NATURE
- BRCA1 Induces Major Energetic Metabolism Reprogramming in Breast Cancer Cells
- (2014) Maud Privat et al. PLoS One
- Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
- (2013) Y Yu et al. BRITISH JOURNAL OF CANCER
- Nicotinamide N-methyltransferase in Non-small Cell Lung Cancer: Promising Results for Targeted Anti-cancer Therapy
- (2013) Davide Sartini et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status
- (2013) Reiko Nishihara et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
- (2013) Olesya A Ulanovskaya et al. Nature Chemical Biology
- RNA-Mediated Gene Silencing of Nicotinamide N-Methyltransferase Is Associated with Decreased Tumorigenicity in Human Oral Carcinoma Cells
- (2013) Valentina Pozzi et al. PLoS One
- Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease
- (2012) Davide Sartini et al. BIOLOGICAL CHEMISTRY
- The expression of nicotinamideN-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors
- (2011) Richard B. Parsons et al. BIOCHEMICAL JOURNAL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Nicotinamide N -methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells
- (2010) Sai-Wen Tang et al. CARCINOGENESIS
- Nicotinamide N-methyltransferase protein expression in renal cell cancer
- (2010) Jun Zhang et al. Journal of Zhejiang University-SCIENCE B
- Serum levels of nicotinamide N-methyltransferase in patients with lung cancer
- (2009) Mikio Tomida et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis
- (2009) Jongmin Kim et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo
- (2009) Jin-Ping Lai et al. JOURNAL OF HEPATOLOGY
- A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
- (2008) Yi Liu et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More