NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide N -Methyltransferase: More Than a Vitamin B3 Clearance Enzyme

(2017) Pavlos Pissios   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PP2A as a master regulator of the cell cycle

(2016) Nathan Wlodarchak et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress‐induced autophagy

(2016) Satoru Torii et al.   EMBO REPORTS

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

(2016) Imanol Zubiete-Franco et al.   JOURNAL OF HEPATOLOGY

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

NNMT: A Bad Actor in Fat Makes Good in Liver

(2015) Samuel A.J. Trammell et al.   Cell Metabolism

Autophagy, Metabolism, and Cancer

(2015) E. White et al.   CLINICAL CANCER RESEARCH

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

(2015) Shangyu Hong et al.   NATURE MEDICINE

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Circumventing Cellular Control of PP2A by Methylation Promotes Transformation in an Akt-Dependent Manner

(2015) Jennifer B. Jackson et al.   NEOPLASIA

Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer

(2014) I Cristóbal et al.   BRITISH JOURNAL OF CANCER

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

(2014) Daniel Kraus et al.   NATURE

BNIP3 is degraded by ULK1-dependent autophagy via MTORC1 and AMPK

(2013) Chang Wook Park et al.   Autophagy

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Protein phosphatase 2A: a target for anticancer therapy

(2013) Danilo Perrotti et al.   LANCET ONCOLOGY

Cancer mistunes methylation

(2013) Tomer Shlomi et al.   Nature Chemical Biology

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

(2013) Olesya A Ulanovskaya et al.   Nature Chemical Biology

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

(2012) Hildegard I.D. Mack et al.   Autophagy

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1

(2011) Vitali Stanevich et al.   MOLECULAR CELL

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis

(2009) Jongmin Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Methionine Metabolism and Liver Disease

(2008) José M. Mato et al.   Annual Review of Nutrition

Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A

(2008) Yongna Xing et al.   CELL

Effect of Rifampicin to Inhibit Rapamycin-Induced Autophagy via the Suppression of Protein Phosphatase 2A Activity

(2008) In-Hoo Park et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY