Review
Endocrinology & Metabolism
Annalisa Roberti, Agustin F. Fernandez, Mario F. Fraga
Summary: NNMT acts as a key link between cellular metabolism and epigenetic gene regulation, playing a central role in various pathologies. Targeting NNMT pathways represents a current pharmaceutical challenge for treating a range of metabolic-related diseases and cancers.
MOLECULAR METABOLISM
(2021)
Article
Plant Sciences
Enhui Yao, Xiazhen Yang, Xuefeng Huang, Yuchen Mi, Xiaoqian Wu, Meijuan Fang, Jinhua Huang, Yan Qiu, Xiaoting Hong, Lu Peng, Jie Ren, Rui Huang, Caixia Chen, Lichao Yang, Yu Zhou, Rengong Zhuo, Xin Jin, Yun Zhao
Summary: WDL reduces fat mass, suppresses body weight gain, and improves obesity-related metabolic disorders in DIO mice. WDL promotes adipose browning and enhances energy expenditure. WDL reverses obesity through inhibiting NNMT and activating the SIRT1/AMPK/PPAR alpha pathway.
Article
Biotechnology & Applied Microbiology
Wanfeng Xu, Ling Hou, Ping Li, Ling Li
Summary: The interference of NNMT expression was found to reduce lipid accumulation and triglyceride content, as well as decrease the expression of certain genes and proteins related to lipid metabolism. This suggests that NNMT plays an important role in the function and metabolism of adipocytes.
Article
Biochemistry & Molecular Biology
Aimo Kannt, Sridharan Rajagopal, Mahanandeesha S. Hallur, Indu Swamy, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Joerg Czech, Gernot Zech, Herman Schreuder, Sven Ruf
Summary: Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). Its expression in various tissues has been linked to metabolic diseases, and potent small molecule inhibitors with different binding modes have been identified through X-ray crystallographic studies.
Article
Biochemistry & Molecular Biology
Roberto Campagna, Lukasz Mateuszuk, Kamila Wojnar-Lason, Patrycja Kaczara, Anna Tworzydlo, Agnieszka Kij, Robert Bujok, Jacek Mlynarski, Yu Wang, Davide Sartini, Monica Emanuelli, Stefan Chlopicki
Summary: Nicotinamide N-methyltransferase (NNMT) plays an important role in endothelial cells by regulating cell viability, possibly through the modulation of SIRT1 expression levels under oxidative stress insult.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Oksana Stepinska, Dorota Dymkowska, Lukasz Mateuszuk, Krzysztof Zablocki
Summary: This study aimed to investigate the potential role of nicotinamide N-methyltransferase in the metabolic response of human aortic endothelial cells. The findings suggest that this enzyme may affect NAD(+) synthesis and epigenetic modifications of chromatin by regulating intracellular nicotinamide and S-adenosylmethionine levels. The specific metabolic role of nicotinamide N-methyltransferase in vascular endothelium is still unclear and further research is needed.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Helena Deris, Petra Tominac, Frano Vuckovic, Arne Astrup, Ellen E. Blaak, Gordan Lauc, Ivan Gudelj
Summary: The aberrant plasma protein glycosylation associated with various diseases was studied by analyzing glycomes from participants of the Diogenes study. Significant alterations in glycan structures were observed 8 weeks after the low-calorie diet, but these effects were nullified during the weight-maintenance diets period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Simone Perna, Zahra Ilyas, Attilio Giacosa, Clara Gasparri, Gabriella Peroni, Milena Anna Faliva, Chiara Rigon, Maurizio Naso, Antonella Riva, Giovanna Petrangolini, Ali A. Redha, Mariangela Rondanelli
Summary: This meta-analysis study found that probiotic supplementation can significantly reduce BMI, waist circumference, and hip circumference in overweight and obese patients, but the effect on body weight is not significant. Although there is a positive trend, further research is needed before recommending probiotics as a therapeutic strategy for these patients.
Article
Health Care Sciences & Services
Scott Hagan, Karin Nelson
Summary: There is significant controversy surrounding the clinical benefits and risks of weight loss interventions for individuals with obesity. Traditional weight-centric approaches may increase weight stigma and cycling without sufficient evidence to support their purported clinical benefits. However, metabolic surgery and pharmacotherapy show clear benefits in certain cases.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Oncology
Jun Yang, Qingchao Tong, Ying Zhang, Shijin Yuan, Yuzhen Gao, Ke Deng, Yanzhong Wang, Jie Lu, Xinyou Xie, Zhe Zhang, Jun Zhang
Summary: This study investigated the distribution of NNMT expression in CRC and found that its overexpression was associated with unfavorable clinical characteristics and survival outcomes. Particularly, high NNMT expression in tumor stroma cells was strongly correlated with metastasis and poor survival in CRC patients. Functional experiments demonstrated that stromal cells with high NNMT expression secreted 1-MAN to promote migration and invasion of CRC cells. Overall, NNMT may serve as a potential prognostic indicator in CRC patients.
Article
Food Science & Technology
Aimei Liu, Mingyue Guo, Lixuan He, Maria-Aranzazu Martinez, Marta Martinez, Bernardo Lopez-Torres, Maria-Rosa Martinez-Larranaga, Xu Wang, Arturo Anadon, Irma Ares
Summary: Deoxynivalenol (DON) is a common contaminant in cereals for infants and can cause growth retardation and inflammation in children. The present research reveals that nicotinamide N-methyltransferase (NNMT) acts as a self-protective factor in DON-exposed cells, alleviating cell growth inhibition by reducing the production of pro-inflammatory cytokines.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Renata Novak Kujundzic, Marin Prpic, Nikola Dakovic, Nina Dabelic, Marko Tomljanovic, Anamarija Mojzes, Ana Frobe, Koraljka Gall Troselj
Summary: Overexpression and activity of NNMT in cancer can disrupt NAD(+) homeostasis and reduce cellular methylation potential. The inhibitory effect of 2-PY on PARP-1 activity, which cancels out NNMT's positive effect on cellular NAD(+) flux, is often overlooked.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Sofus C. Larsen, Jake Turicchi, Gitte L. Christensen, Charlotte S. Larsen, Niklas R. Jorgensen, Marie-Louise K. Mikkelsen, Graham Horgan, Ruairi O'Driscoll, Joanna Michalowska, Cristiana Duarte, Sarah E. Scott, Ines Santos, Jorge Encantado, Antonio L. Palmeira, R. James Stubbs, Berit L. Heitmann
Summary: Several cross-sectional studies have shown an association between hair cortisol concentration and adiposity, but the relationship with longitudinal changes in measures of adiposity remains largely unknown. In this study of 786 adults who achieved successful weight loss, increased hair cortisol concentration during a 12-month weight loss maintenance period was associated with slightly higher body weight variability in the subsequent 6 months.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Nathalie Kliemann, Vivian Viallon, Neil Murphy, Rebecca J. Beeken, Joseph A. Rothwell, Sabina Rinaldi, Nada Assi, Eline H. van Roekel, Julie A. Schmidt, Kristin Benjaminsen Borch, Claudia Agnoli, Ann H. Rosendahl, Hanna Sartor, Jose Maria Huerta, Anne Tjonneland, Jytte Halkjaer, Bas Bueno-de-Mesquita, Audrey Gicquiau, David Achaintre, Krasimira Aleksandrova, Matthias B. Schulze, Alicia K. Heath, Konstantinos K. Tsilidis, Giovanna Masala, Salvatore Panico, Rudolf Kaaks, Renee T. Fortner, Bethany Van Guelpen, Laure Dossus, Augustin Scalbert, Hector C. Keun, Ruth C. Travis, Mazda Jenab, Mattias Johansson, Pietro Ferrari, Marc J. Gunter
Summary: Obesity is associated with specific changes in levels of amino acids and lipids, which are positively correlated with the risk of colorectal and endometrial cancer and may be reversible following weight loss.
Article
Nutrition & Dietetics
Katarzyna Ilowiecka, Pawel Glibowski, Michal Skrzypek, Wojciech Styk
Summary: The study suggests that post-therapeutic support after weight loss can increase the chances of long-term weight maintenance in obesity treatment, and may be influenced by certain genotypes.
Article
Chemistry, Medicinal
Harshini Neelakantan, Hua-Yu Wang, Virginia Vance, Jonathan D. Hommel, Stanton F. McHardy, Stanley J. Watowich
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Neurosciences
Elizabeth J. Crofton, Miroslav N. Nenov, Yafang Zhang, Federico Scala, Sean A. Page, David L. McCue, Dingge Li, Jonathan D. Hommel, Fernanda Laezza, Thomas A. Green
Editorial Material
Developmental Biology
Jonathan D. Hommel
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2018)
Review
Developmental Biology
J. M. Kasper, A. J. Milton, A. E. Smith, F. Laezza, G. Taglialatela, J. D. Hommel, N. Abate
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2018)
Article
Neurosciences
C. R. Benzon, S. B. Johnson, D. L. McCue, D. Li, T. A. Green, J. D. Hommel
Article
Pharmacology & Pharmacy
Amanda E. Price, Noelle C. Anastasio, Sonja J. Stutz, Jonathan D. Hommel, Kathryn A. Cunningham
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Nutrition & Dietetics
Ashley E. Smith, James M. Kasper, Noelle C. Anastasio, Jonathan D. Hommel
Article
Neurosciences
Erica L. McGrath, Caitlin R. Schlagal, Ibdanelo Cortez, Tiffany J. Dunn, Junling Gao, Robert G. Fox, Sonja J. Stutz, Yong-Fang Kuo, Jonathan D. Hommel, Kelly T. Dineley, Kathryn A. Cunningham, Bhupendra S. Kaphalia, Ping Wu
Article
Multidisciplinary Sciences
Catherine M. Sampson, Andrea L. Dimet, Harshini Neelakantan, Kehinde O. Ogunseye, Heather L. Stevenson, Jonathan D. Hommel, Stanley J. Watowich
Summary: The study demonstrated that nicotinamide N-methyltransferase inhibitor (NNMTi) treatment combined with a lean diet substitution can accelerate weight loss, improve body weight and fat reduction, and have a significant impact on the whole-body lean mass to body weight ratio and liver fat accumulation. Additionally, NNMTi treatment can also improve body composition and liver fat accumulation parameters.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Neurosciences
Ashley E. Smith, Jonathan D. Hommel
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
James M. Kasper, Ashley E. Smith, Sierra N. Miller, Ara, William K. Russell, Kathryn A. Cunningham, Jonathan D. Hommel
Summary: The neurotransmitter neuromedin U (NMU) and its receptor were found to regulate motivation for cocaine, affecting GABA release and c-Fos expression, leading to reduced breakpoints for cocaine. Using viral transsynaptic studies, it was discovered that NMU impacts the GABAergic pathway from the dorsal raphe nucleus to the nucleus accumbens shell to the ventral pallidum. These findings advance understanding of the neurochemical regulation of pathways specific to cocaine self-administration.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biology
Gabriella Born-Evers, Ashley L. Orr, Elizabeth Q. Hulsey, Maria E. Squire, Julia M. Hum, Lilian Plotkin, Catherine Sampson, Jonathan Hommel, Jonathan W. Lowery
Summary: Knocking down Nmu expression in the hypothalamus of male rats did not result in significant changes in bone mass, suggesting that hypothalamus-derived NMU does not directly regulate bone remodeling in the postnatal skeleton. Further studies are needed to determine the direct versus indirect effects of NMU on bone remodeling.
Article
Medicine, Research & Experimental
Celia Chao, Kevin Wooten, Heidi Spratt, Huda Sarraj, Judith Aronson, Jonathan Hommel, Ross Ungerleider, Jamie D. Ungerleider, Mark R. Hellmich
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2018)
Article
Neurosciences
Jonathan D. Hommel, Richard Trinko, Robert M. Sears, Dan Georgescu, Zong-Wu Liu, Xiao-Bing Gao, Jeremy J. Thurmon, Michela Marinelli, Ralph J. DiLeone
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)