- Home
- Publications
- Publication Search
- Publication Details
Title
Thymus Functionality Needs More Than a Few TECs
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-06-10
DOI
10.3389/fimmu.2022.864777
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations
- (2021) Giuliana Giardino et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
- (2021) Jhoanne L. Bautista et al. Nature Communications
- Evolution of thymopoietic microenvironments
- (2021) Ryo Morimoto et al. Open Biology
- Current and Future Therapeutic Approaches for Thymic Stromal Cell Defects
- (2021) Alexandra Y. Kreins et al. Frontiers in Immunology
- EBMT/ESID inborn errors working party guidelines for hematopoietic stem cell transplantation for inborn errors of immunity
- (2021) A. C. Lankester et al. BONE MARROW TRANSPLANTATION
- The fibroblast: An emerging key player in thymic T cell selection
- (2021) Takeshi Nitta et al. IMMUNOLOGICAL REVIEWS
- DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
- (2021) Ashton C. Trotman-Grant et al. Nature Communications
- Early Thymectomy Is Associated With Long-Term Impairment of the Immune System: A Systematic Review
- (2021) Nara Vasconcelos Cavalcanti et al. Frontiers in Immunology
- V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation
- (2020) Xiying Chi et al. IMMUNOLOGY
- A cell atlas of human thymic development defines T cell repertoire formation
- (2020) Jong-Eun Park et al. SCIENCE
- Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice
- (2020) Ken-ichi Hirano et al. eLife
- The Genetics and Epigenetics of 22q11.2 Deletion Syndrome
- (2020) Qiumei Du et al. Frontiers in Genetics
- PAX1 is essential for development and function of the human thymus
- (2020) Yasuhiro Yamazaki et al. Science Immunology
- Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development
- (2020) Dong Liu et al. DEVELOPMENT
- NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development
- (2020) Jie Li et al. DEVELOPMENT
- Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
- (2020) Qiang Cheng et al. Nature Nanotechnology
- Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models
- (2020) Pratibha Bhalla et al. Frontiers in Immunology
- Generation and Regeneration of Thymic Epithelial Cells
- (2020) Abdullah S. Alawam et al. Frontiers in Immunology
- Structural cells are key regulators of organ-specific immune responses
- (2020) Thomas Krausgruber et al. NATURE
- When the Damage Is Done: Injury and Repair in Thymus Function
- (2020) Sinéad Kinsella et al. Frontiers in Immunology
- Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblast (FREF) to counteract age-related inflammation
- (2020) Jiyoung Oh et al. JCI Insight
- Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency
- (2020) Panojot Bifsha et al. Blood Advances
- Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia
- (2020) Marita Bosticardo et al. Blood Advances
- Fibroblasts as a source of self-antigens for central immune tolerance
- (2020) Takeshi Nitta et al. NATURE IMMUNOLOGY
- Spectrum of Fibrotic Lung Diseases
- (2020) Marlies Wijsenbeek et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ageing compromises mouse thymus function and remodels epithelial cell differentiation
- (2020) Jeanette Baran-Gale et al. eLife
- Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
- (2020) Sara Campinoti et al. Nature Communications
- Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells
- (2020) Kristen L Wells et al. eLife
- Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells
- (2019) Brian M. Larsen et al. JOURNAL OF IMMUNOLOGY
- Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis
- (2019) Marita Bosticardo et al. AMERICAN JOURNAL OF HUMAN GENETICS
- FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans
- (2019) Qiumei Du et al. JOURNAL OF CLINICAL INVESTIGATION
- Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos
- (2019) Yang Zeng et al. IMMUNITY
- Comment on “Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells”
- (2019) Adam E. Handel et al. JOURNAL OF IMMUNOLOGY
- Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
- (2019) Jennifer E. Cowan et al. Nature Communications
- Long-term clinical effects of early thymectomy: Associations with autoimmune diseases, cancer, infections, and atopic diseases
- (2018) Judith Gudmundsdottir et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Thymic tolerance as a key brake on autoimmunity
- (2018) Mickie Cheng et al. NATURE IMMUNOLOGY
- Mechanisms of Tolerance Induction by Dendritic Cells In Vivo
- (2018) Hitoshi Hasegawa et al. Frontiers in Immunology
- Twenty Years of AIRE
- (2018) Roberto Perniola Frontiers in Immunology
- Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells
- (2018) Chamutal Bornstein et al. NATURE
- Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development
- (2018) Corey N. Miller et al. NATURE
- Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho
- (2018) Yan Xing et al. JOURNAL OF IMMUNOLOGY
- FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche
- (2017) Kirsten M. Williams et al. EXPERIMENTAL HEMATOLOGY
- Update on Aire and thymic negative selection
- (2017) Geraldo A. Passos et al. IMMUNOLOGY
- Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype
- (2017) Min Su et al. IMMUNOLOGY AND CELL BIOLOGY
- The Importance of Dendritic Cells in Maintaining Immune Tolerance
- (2017) Cindy Audiger et al. JOURNAL OF IMMUNOLOGY
- Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids
- (2017) Christopher S Seet et al. NATURE METHODS
- Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
- (2017) Muhammad Myn Uddin et al. Nature Communications
- Modeling Development and Disease with Organoids
- (2016) Hans Clevers CELL
- FOXN1 recombinant protein enhances T-cell regeneration after hematopoietic stem cell transplantation in mice
- (2016) Yinhong Song et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- FOXN1 in thymus organogenesis and development
- (2016) Harsh Jayesh Vaidya et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Sonic Hedgehog regulates thymic epithelial cell differentiation
- (2016) José Ignacio Saldaña et al. JOURNAL OF AUTOIMMUNITY
- MicroRNA-205 Maintains T Cell Development following Stress by RegulatingForkhead Box N1and Selected Chemokines
- (2016) Ashley R. Hoover et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Randomized Trial of Thymectomy in Myasthenia Gravis
- (2016) Gil I. Wolfe et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
- (2016) Yun-Hee Youm et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration
- (2016) Yaoyao Shi et al. Nature Communications
- Context-Dependent Development of Lymphoid Stroma from Adult CD34+ Adventitial Progenitors
- (2016) Katarzyna M. Sitnik et al. Cell Reports
- Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus
- (2016) Svetlana Ulyanchenko et al. Cell Reports
- Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells
- (2016) Rumi Satoh et al. PLoS Genetics
- Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers
- (2015) N Anandasabapathy et al. BONE MARROW TRANSPLANTATION
- Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
- (2015) Mi-Jeong Kim et al. JOURNAL OF IMMUNOLOGY
- Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts
- (2015) Yong Fan et al. MOLECULAR THERAPY
- A draft network of ligand–receptor-mediated multicellular signalling in human
- (2015) Jordan A. Ramilowski et al. Nature Communications
- The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus
- (2015) Zicheng Hu et al. Frontiers in Immunology
- Regeneration of the aged thymus by a single transcription factor
- (2014) N. Bredenkamp et al. DEVELOPMENT
- Neural Crest Origin of Perivascular Mesenchyme in the Adult Thymus
- (2014) S. M. Muller et al. JOURNAL OF IMMUNOLOGY
- Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus
- (2014) K. Foster et al. JOURNAL OF IMMUNOLOGY
- An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts
- (2014) Nicholas Bredenkamp et al. NATURE CELL BIOLOGY
- Engineering the Human Thymic Microenvironment to Support Thymopoiesis In Vivo
- (2014) Brile Chung et al. STEM CELLS
- Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice
- (2014) L Ruan et al. Cell Death & Disease
- Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult Thymus
- (2014) Kahlia Wong et al. Cell Reports
- Routine thymectomy in congenital cardiac surgery changes adaptive immunity without clinical relevance
- (2014) Jorg Roosen et al. Interactive Cardiovascular and Thoracic Surgery
- Novel mutations in the geneHOXC13underlying pure hair and nail ectodermal dysplasia in consanguineous families
- (2013) R.H. Ali et al. BRITISH JOURNAL OF DERMATOLOGY
- Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+and FoxP3−T cells in complete DiGeorge anomaly
- (2013) I. K. Chinn et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Damage control: Rorγt+ innate lymphoid cells in tissue regeneration
- (2013) Monica Romera-Hernandez et al. CURRENT OPINION IN IMMUNOLOGY
- Dynamics of thymus organogenesis and colonization in early human development
- (2013) A. M. Farley et al. DEVELOPMENT
- Generation of both cortical and Aire+medullary thymic epithelial compartments from CD205+progenitors
- (2013) Song Baik et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development
- (2013) Jennifer E. Cowan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Thymocyte Selection Regulates the Homeostasis of IL-7-Expressing Thymic Cortical Epithelial Cells In Vivo
- (2013) A. R. Ribeiro et al. JOURNAL OF IMMUNOLOGY
- Lymphotoxin Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells
- (2013) E. Lkhagvasuren et al. JOURNAL OF IMMUNOLOGY
- IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCR + Intraepithelial Lymphocytes
- (2013) S. Shitara et al. JOURNAL OF IMMUNOLOGY
- Cell-Autonomous Defects in Thymic Epithelial Cells Disrupt Endothelial-Perivascular Cell Interactions in the Mouse Thymus
- (2013) Jerrod L. Bryson et al. PLoS One
- Aire-expressing thymic medullary epithelial cells originate from 5t-expressing progenitor cells
- (2013) I. Ohigashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging
- (2013) P Burnley et al. Cell Death & Disease
- Immunodeficiency in DiGeorge Syndrome and Options for Treating Cases with Complete Athymia
- (2013) E. Graham Davies Frontiers in Immunology
- The Effect of Age on Thymic Function
- (2013) Donald B. Palmer Frontiers in Immunology
- FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program
- (2013) Rosa Romano et al. Frontiers in Immunology
- Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis
- (2012) J. R. Gardiner et al. DEVELOPMENT
- Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation
- (2012) R.-A. Romano et al. DEVELOPMENT
- Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium
- (2012) Natalie A. Roberts et al. IMMUNITY
- Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development
- (2012) Konstantina Alexandropoulos et al. IMMUNOLOGIC RESEARCH
- Mesenchymal Cells Regulate Retinoic Acid Receptor-Dependent Cortical Thymic Epithelial Cell Homeostasis
- (2012) K. M. Sitnik et al. JOURNAL OF IMMUNOLOGY
- Interleukin-22 Drives Endogenous Thymic Regeneration in Mice
- (2012) J. A. Dudakov et al. SCIENCE
- Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells
- (2011) E. C. Zook et al. BLOOD
- Mechanisms of thymus organogenesis and morphogenesis
- (2011) J. Gordon et al. DEVELOPMENT
- FOXN1 mutation abrogates prenatal T-cell development in humans
- (2011) I. Vigliano et al. JOURNAL OF MEDICAL GENETICS
- The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor
- (2011) Aikaterini S Papadopoulou et al. NATURE IMMUNOLOGY
- Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
- (2011) M. Giraud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus
- (2011) L. Calderon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution
- (2010) Liguang Sun et al. AGING CELL
- First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases
- (2010) M. L. Markert et al. BLOOD
- Thymic fatness and approaches to enhance thymopoietic fitness in aging
- (2010) Vishwa Deep Dixit CURRENT OPINION IN IMMUNOLOGY
- Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis
- (2010) Julie Gordon et al. DEVELOPMENTAL BIOLOGY
- The role of Aire in clonal selection
- (2010) Ruth T Taniguchi et al. IMMUNOLOGY AND CELL BIOLOGY
- Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells
- (2010) A. J. White et al. JOURNAL OF IMMUNOLOGY
- The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation
- (2010) Christopher S. Potter et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium
- (2010) Jianfei Guo et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- EphB-ephrin-B2 interactions are required for thymus migration during organogenesis
- (2010) K. E. Foster et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Thyroid Cancer Risk 40+ Years after Irradiation for an Enlarged Thymus: An Update of the Hempelmann Cohort
- (2010) (Michael) Jacob Adams et al. RADIATION RESEARCH
- Neural Crest-Derived Pericytes Promote Egress of Mature Thymocytes at the Corticomedullary Junction
- (2010) M. A. Zachariah et al. SCIENCE
- Aire
- (2009) Diane Mathis et al. Annual Review of Immunology
- Foxn1 is essential for vascularization of the murine thymus anlage
- (2009) Kazuya Mori et al. CELLULAR IMMUNOLOGY
- Evidence of premature immune aging in patients thymectomized during early childhood
- (2009) Delphine Sauce et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of Thymic Adipogenesis by Caloric Restriction Is Coupled with Reduction in Age-Related Thymic Involution
- (2009) H. Yang et al. JOURNAL OF IMMUNOLOGY
- Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling
- (2009) Hyunwon Yang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Visualization and Identification of IL-7 Producing Cells in Reporter Mice
- (2009) Renata I. Mazzucchelli et al. PLoS One
- Characterization of the thymic IL-7 niche in vivo
- (2009) N. L. Alves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens
- (2009) T. Nitta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner
- (2008) L. Chen et al. BLOOD
- VEGF-mediated cross-talk within the neonatal murine thymus
- (2008) A. R. Cuddihy et al. BLOOD
- The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator
- (2008) Yu Hikosaka et al. IMMUNITY
- The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance
- (2008) Taishin Akiyama et al. IMMUNITY
- Deficient Ghrelin Receptor-mediated Signaling Compromises Thymic Stromal Cell Microenvironment by Accelerating Thymic Adiposity
- (2008) Yun-Hee Youm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Delta-like 4 is indispensable in thymic environment specific for T cell development
- (2008) Katsuto Hozumi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
- (2008) Ute Koch et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cytokines, leptin, and stress-induced thymic atrophy
- (2008) Amanda L. Gruver et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Age-related changes in the human thymus studied with scanning electron microscopy
- (2008) Carlo Cavallotti et al. MICROSCOPY RESEARCH AND TECHNIQUE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started