The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus

CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice

(2015) Beth Lucas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

(2015) Tomoyoshi Yamano et al.   IMMUNITY

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection

(2015) Amine Boudil et al.   NATURE IMMUNOLOGY

Population and single-cell genomics reveal theAiredependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

(2014) Stephen N. Sansom et al.   GENOME RESEARCH

Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus

(2014) Justin S.A. Perry et al.   IMMUNITY

Thymic CCL2 influences induction of T-cell tolerance

(2014) O. Cédile et al.   JOURNAL OF AUTOIMMUNITY

Alterations of the Medullary Epithelial Compartment in the Aire-Deficient Thymus: Implications for Programs of Thymic Epithelial Differentiation

(2014) J. Dooley et al.   JOURNAL OF IMMUNOLOGY

Thymocyte-Dendritic Cell Interactions near Sources of CCR7 Ligands in the Thymic Cortex

(2014) E. Ladi et al.   JOURNAL OF IMMUNOLOGY

Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive   T Cells in the Adult Thymus

(2014) J. E. Cowan et al.   JOURNAL OF IMMUNOLOGY

An Overview of the Intrathymic Intricacies of T Cell Development

(2014) D. K. Shah et al.   JOURNAL OF IMMUNOLOGY

Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns

(2014) J. O. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Transcriptional Profiling Reveals Distinct Functions of Thymic Stromal Subsets and Age-Related Changes during Thymic Involution

(2014) Sanghee Ki et al.   Cell Reports

From pre-DP, post-DP, SP4, and SP8 Thymocyte Cell Counts to a Dynamical Model of Cortical and Medullary Selection

(2014) Maria Sawicka et al.   Frontiers in Immunology

Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes

(2013) Yana Wang et al.   Integrative Biology

Medullary thymic epithelial cell depletion leads to autoimmune hepatitis

(2013) Anthony J. Bonito et al.   JOURNAL OF CLINICAL INVESTIGATION

Opposing chemokine gradients control human thymocyte migration in situ

(2013) Joanna Halkias et al.   JOURNAL OF CLINICAL INVESTIGATION

Helios marks strongly autoreactive CD4+T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB

(2013) Stephen R. Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

(2013) Martin Aichinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphotoxin   Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells

(2013) E. Lkhagvasuren et al.   JOURNAL OF IMMUNOLOGY

Dynamic control of  1 integrin adhesion by the plexinD1-sema3E axis

(2013) Y. I. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development

(2013) S. R. Jenkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine thymic selection quantified using a unique method to capture deleted T cells

(2013) G. L. Stritesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection

(2013) J. Perera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lineage Tracing and Cell Ablation Identify a Post-Aire-Expressing Thymic Epithelial Cell Population

(2013) Todd C. Metzger et al.   Cell Reports

Plxnd1 Expression in Thymocytes Regulates Their Intrathymic Migration While That in Thymic Endothelium Impacts Medullary Topology

(2013) Young I. Choi et al.   Frontiers in Immunology

CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity

(2012) M. D. Bunting et al.   BLOOD

β5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells

(2012) Yousuke Takahama et al.   CURRENT OPINION IN IMMUNOLOGY

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

Plasmacytoid Dendritic Cells Transport Peripheral Antigens to the Thymus to Promote Central Tolerance

(2012) Husein Hadeiba et al.   IMMUNITY

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus

(2012) Yoshihiro Ueda et al.   Nature Communications

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

(2011) F.-X. Hubert et al.   BLOOD

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

(2011) Yu Lei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell Lineage Commitment: Identity and Renunciation

(2011) E. V. Rothenberg   JOURNAL OF IMMUNOLOGY

Functions of Notch Signaling in the Immune System: Consensus and Controversies

(2010) Julie S. Yuan et al.   Annual Review of Immunology

In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors

(2010) L. I. Richie Ehrlich et al.   BLOOD

Fate Mapping Reveals Separate Origins of T Cells and Myeloid Lineages in the Thymus

(2010) Susan M. Schlenner et al.   IMMUNITY

Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

(2010) Yumiko Nishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of thymocyte positive selection and motility by GIT2

(2010) Hyewon Phee et al.   NATURE IMMUNOLOGY

Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

(2010) Maria Hinterberger et al.   NATURE IMMUNOLOGY

B Cells Participate in Thymic Negative Selection of Murine Auto-reactive CD4+ T Cells

(2010) Friederike Frommer et al.   PLoS One

CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

(2009) D. A. Zlotoff et al.   BLOOD

CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus

(2009) A. Krueger et al.   BLOOD

Differential Contribution of Chemotaxis and Substrate Restriction to Segregation of Immature and Mature Thymocytes

(2009) Lauren I. Richie Ehrlich et al.   IMMUNITY

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

(2009) Christian Koble et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

(2009) JiChu Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial Contribution of Thymic Sirp + Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner

(2009) T. Baba et al.   JOURNAL OF IMMUNOLOGY

CXCR4 acts as a costimulator during thymic β-selection

(2009) Paul C Trampont et al.   NATURE IMMUNOLOGY

The impact of negative selection on thymocyte migration in the medulla

(2009) Marie Le Borgne et al.   NATURE IMMUNOLOGY

CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens

(2009) T. Nitta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis

(2008) T. Serwold et al.   BLOOD

Intercellular MHC transfer between thymic epithelial and dendritic cells

(2008) Virginie Millet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome

(2008) Tal Birnberg et al.   IMMUNITY

PlexinD1 Glycoprotein Controls Migration of Positively Selected Thymocytes into the Medulla

(2008) Young I. Choi et al.   IMMUNITY

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

(2008) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

(2008) Masashi Yano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity

(2008) A. S. Koh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

(2008) J. Derbinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA