Single cell transcriptomics reveals dysregulated cellular and molecular networks in a fragile X syndrome model

The molecular biology of FMRP: new insights into fragile X syndrome

(2021) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial

(2021) Elizabeth M. Berry-Kravis et al.   NATURE MEDICINE

A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

(2021) Yunhee Kang et al.   NATURE NEUROSCIENCE

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndrome

(2020) Kagistia Hana Utami et al.   BIOLOGICAL PSYCHIATRY

Identification of FMR1-regulated molecular networks in human neurodevelopment

(2020) Meng Li et al.   GENOME RESEARCH

Agonist-induced functional analysis and cell sorting associated with single-cell transcriptomics characterizes cell subtypes in normal and pathological brain

(2020) Sara Castagnola et al.   GENOME RESEARCH

FMRP links optimal codons to mRNA stability in neurons

(2020) Huan Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell transcriptomic analysis of mouse neocortical development

(2019) Lipin Loo et al.   Nature Communications

Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation

(2019) Rong Jia et al.   RNA

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

(2019) Eric Wang et al.   CANCER CELL

Altered cortical Cytoarchitecture in the Fmr1 knockout mouse

(2019) Frankie H. F. Lee et al.   Molecular Brain

The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs

(2019) Phillip J. Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modelling fragile X syndrome in the laboratory setting: A behavioral perspective

(2018) Francesca Melancia et al.   BEHAVIOURAL BRAIN RESEARCH

Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies

(2018) Anwesha Banerjee et al.   BRAIN RESEARCH

OUP accepted manuscript

(2018)   CEREBRAL CORTEX

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

(2018) Laleh Haghverdi et al.   NATURE BIOTECHNOLOGY

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

(2018) Isabella Farhy-Tselnicker et al.   Neural Development

HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein

(2018) Thomas Maurin et al.   NUCLEIC ACIDS RESEARCH

Development of White Matter Circuitry in Infants With Fragile X Syndrome

(2018) Meghan R. Swanson et al.   JAMA Psychiatry

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Regulation of IL-6 Secretion by Astrocytes via TLR4 in the Fragile X Mouse Model

(2018) Victoria Krasovska et al.   Frontiers in Molecular Neuroscience

Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140

(2018) Mateusz C. Ambrozkiewicz et al.   NEURON

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Delayed Maturation of Fast-Spiking Interneurons Is Rectified by Activation of the TrkB Receptor in the Mouse Model of Fragile X Syndrome

(2017) Toshihiro Nomura et al.   JOURNAL OF NEUROSCIENCE

Increased Neuronal Differentiation of Neural Progenitor Cells Derived from Phosphovimentin-Deficient Mice

(2017) Meng Chen et al.   MOLECULAR NEUROBIOLOGY

Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome

(2017) Elizabeth M. Berry-Kravis et al.   NATURE REVIEWS DRUG DISCOVERY

Neuronal cell-type classification: challenges, opportunities and the path forward

(2017) Hongkui Zeng et al.   NATURE REVIEWS NEUROSCIENCE

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

(2017) Sophie R. Thomson et al.   NEURON

A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14

(2017) Lin-Tao Zhou et al.   NEUROSCIENCE

Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse

(2017) Alice Filippini et al.   RNA Biology

Multifarious Functions of the Fragile X Mental Retardation Protein

(2017) Jenna K. Davis et al.   TRENDS IN GENETICS

mTOR-Dependent Cell Proliferation in the Brain

(2017) Larisa Ryskalin et al.   Biomed Research International

Altered Developmental Expression of the Astrocyte-Secreted Factors Hevin and SPARC in the Fragile X Mouse Model

(2017) Jessica Wallingford et al.   Frontiers in Molecular Neuroscience

Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)

(2017) Mark E. Gurney et al.   Scientific Reports

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data

(2016) Alan Derr et al.   GENOME RESEARCH

Cellular distribution of the fragile X mental retardation protein in the mouse brain

(2016) Diego A.R. Zorio et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Developmental experience-dependent plasticity in the first synapse of the Drosophila olfactory circuit

(2016) Randall M. Golovin et al.   JOURNAL OF NEUROPHYSIOLOGY

Role of astrocyte-synapse interactions in CNS disorders

(2016) Elena Blanco-Suárez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

(2016) Eric L Van Nostrand et al.   NATURE METHODS

Single-cell barcoding and sequencing using droplet microfluidics

(2016) Rapolas Zilionis et al.   Nature Protocols

Astrocyte-Secreted Factors Selectively Alter Neural Stem and Progenitor Cell Proliferation in the Fragile X Mouse

(2016) Mary Sourial et al.   Frontiers in Cellular Neuroscience

Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model

(2016) Connie Cheng et al.   Molecular Brain

D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures

(2016) Alan C. Foster et al.   PLoS One

Expression of fragile X mental retardation protein in neurons and glia of the developing and adult mouse brain

(2015) Shervin Gholizadeh et al.   BRAIN RESEARCH

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

Spliceosomes

(2015) Weijun Chen et al.   CURRENT BIOLOGY

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

(2015) K. M. Huber et al.   JOURNAL OF NEUROSCIENCE

Database resources of the National Center for Biotechnology Information

(2015)   NUCLEIC ACIDS RESEARCH

Postsynaptic VAMP/Synaptobrevin Facilitates Differential Vesicle Trafficking of GluA1 and GluA2 AMPA Receptor Subunits

(2015) Suleman Hussain et al.   PLoS One

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor activation regulates sociability by its effect on mTOR signaling activity

(2015) Jessica A. Burket et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish

(2015) Adi Shamay-Ramot et al.   PLoS Genetics

Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells

(2015) Tomer Halevy et al.   Stem Cell Reports

A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response

(2014) Roman Alpatov et al.   CELL

A feed-forward mechanism involving Drosophila fragile X mental retardation protein triggers a replication stress-induced DNA damage response

(2014) W. Zhang et al.   HUMAN MOLECULAR GENETICS

The Developmental Switch in GABA Polarity Is Delayed in Fragile X Mice

(2014) Q. He et al.   JOURNAL OF NEUROSCIENCE

Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model

(2014) H. Sidhu et al.   JOURNAL OF NEUROSCIENCE

Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome

(2014) Eileen Chen et al.   MOLECULAR CELL

FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry

(2014) Giorgio La Fata et al.   NATURE NEUROSCIENCE

Clustering by fast search and find of density peaks

(2014) A. Rodriguez et al.   SCIENCE

SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth

(2013) Anna Corradi et al.   HUMAN MOLECULAR GENETICS

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels

(2013) Pan-Yue Deng et al.   NEURON

FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control

(2013) I. P. Sudhakaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Fragile X Mental Retardation Protein Is localized to Cajal Bodies

(2013) Alain Y. Dury et al.   PLoS Genetics

Lack of lipid phosphate phosphatase-3 in embryonic stem cells compromises neuronal differentiation and neurite outgrowth

(2012) Roberto Sánchez-Sánchez et al.   DEVELOPMENTAL DYNAMICS

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

(2012) C. A. Hoeffer et al.   GENES BRAIN AND BEHAVIOR

Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome

(2012) Sally M. Till et al.   HUMAN MOLECULAR GENETICS

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

Presynaptically Released Cbln1 Induces Dynamic Axonal Structural Changes by Interacting with GluD2 during Cerebellar Synapse Formation

(2012) Aya Ito-Ishida et al.   NEURON

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

The role of Ca2+-stimulated adenylyl cyclases in bidirectional synaptic plasticity and brain function

(2012) Hongbing Wang et al.   REVIEWS IN THE NEUROSCIENCES

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

(2012) Ingrid Chamma et al.   Frontiers in Cellular Neuroscience

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Eph receptors and ephrins in neuron-astrocyte communication at synapses

(2011) Keith K. Murai et al.   GLIA

Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome

(2011) Claudia M Greco et al.   Molecular Autism

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Astrocytes Prevent Abnormal Neuronal Development in the Fragile X Mouse

(2010) S. Jacobs et al.   JOURNAL OF NEUROSCIENCE

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

(2010) Maile R Brown et al.   NATURE NEUROSCIENCE

Critical Period Plasticity Is Disrupted in the Barrel Cortex of Fmr1 Knockout Mice

(2010) Emily G. Harlow et al.   NEURON

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Regulation of Glutamate Transport in Developing Rat Oligodendrocytes

(2009) T. M. DeSilva et al.   JOURNAL OF NEUROSCIENCE

Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability

(2009) Silvia De Rubeis et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

(2009) Gary A. Wayman et al.   NEURON

A Novel Function for Fragile X Mental Retardation Protein in Translational Activation

(2009) Elias G Bechara et al.   PLOS BIOLOGY

Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome

(2008) Gül Dölen et al.   JOURNAL OF PHYSIOLOGY-LONDON