Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model

Expression of fragile X mental retardation protein in neurons and glia of the developing and adult mouse brain

(2015) Shervin Gholizadeh et al.   BRAIN RESEARCH

Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins:in vitroandin vivostudies

(2014) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROCHEMISTRY

Common and rare variants of the THBS1 gene associated with the risk for autism

(2014) Lina Lu et al.   PSYCHIATRIC GENETICS

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

(2014) Giulia E. Tyzack et al.   Nature Communications

Fluorescent labeling of dendritic spines in cell cultures with the carbocyanine dye “DiI”

(2014) Connie Cheng et al.   Frontiers in Neuroanatomy

Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease

(2014) Emma V. Jones et al.   NEURAL PLASTICITY

Fragile X syndrome: From protein function to therapy

(2013) Claudia Bagni et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse

(2013) Haruki Higashimori et al.   HUMAN MOLECULAR GENETICS

Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome

(2012) Sally M. Till et al.   HUMAN MOLECULAR GENETICS

Astrocyte-Derived Thrombospondins Mediate the Development of Hippocampal Presynaptic Plasticity In Vitro

(2012) D. C. Crawford et al.   JOURNAL OF NEUROSCIENCE

Thrombospondins as key regulators of synaptogenesis in the central nervous system

(2012) W. Christopher Risher et al.   MATRIX BIOLOGY

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant

(2012) Andreea S. Pop et al.   PSYCHOPHARMACOLOGY

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

What Can We Learn about Autism from Studying Fragile X Syndrome?

(2011) Dejan B. Budimirovic et al.   DEVELOPMENTAL NEUROSCIENCE

A new indirect co-culture set up of mouse hippocampal neurons and cortical astrocytes on microelectrode arrays

(2011) Maren Geissler et al.   JOURNAL OF NEUROSCIENCE METHODS

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

(2011) Josien Levenga et al.   NEUROBIOLOGY OF DISEASE

Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice

(2011) Cara J. Westmark et al.   PLoS One

The Thrombospondins

(2011) J. C. Adams et al.   Cold Spring Harbor Perspectives in Biology

Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression

(2010) Shelley Jacobs et al.   BMC NEUROSCIENCE

Secreted factors as synaptic organizers

(2010) Erin M. Johnson-Venkatesh et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Morphine Modulation of Thrombospondin Levels in Astrocytes and Its Implications for Neurite Outgrowth and Synapse Formation

(2010) Hiroko Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes Prevent Abnormal Neuronal Development in the Fragile X Mouse

(2010) S. Jacobs et al.   JOURNAL OF NEUROSCIENCE

Delayed Stabilization of Dendritic Spines in Fragile X Mice

(2010) A. Cruz-Martin et al.   JOURNAL OF NEUROSCIENCE

The Evolution of Thrombospondins and Their Ligand-Binding Activities

(2010) A. A. Bentley et al.   MOLECULAR BIOLOGY AND EVOLUTION

Critical Period Plasticity Is Disrupted in the Barrel Cortex of Fmr1 Knockout Mice

(2010) Emily G. Harlow et al.   NEURON

A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

(2010) Octavio Garcia et al.   PLoS One

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

(2010) Feng Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

(2010) Randi Hagerman et al.   Molecular Autism

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

Identification of Astrocyte Secreted Proteins with a Combination of Shotgun Proteomics and Bioinformatics

(2009) James A. Dowell et al.   JOURNAL OF PROTEOME RESEARCH

Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport

(2009) M. A. Carmona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of astrocyte-secreted matricellular proteins in central nervous system development and function

(2009) Cagla Eroglu   Journal of Cell Communication and Signaling

Thrombospondins 1 and 2 are Necessary for Synaptic Plasticity and Functional Recovery after Stroke

(2008) Jason Liauw et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice

(2008) I. Bureau et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

(2008) Femke M.S. de Vrij et al.   NEUROBIOLOGY OF DISEASE

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON