Identification of FMR1-regulated molecular networks in human neurodevelopment

Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders

(2019) Jocelynn R. Pearl et al.   Cell Systems

Impaired Ribosomal Biogenesis by Non-Canonical Degradation of β-catenin during Hyperammonemia

(2019) Gangarao Davuluri et al.   MOLECULAR AND CELLULAR BIOLOGY

Inferring Regulatory Programs Governing Region Specificity of Neuroepithelial Stem Cells during Early Hindbrain and Spinal Cord Development

(2019) Deborah Chasman et al.   Cell Systems

The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling

(2019) Sotaro Ichinose et al.   Cell Reports

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

(2019) Kirsty Sawicka et al.   eLife

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis

(2018) Carla G. Silva et al.   CELL

The COPII cargo adapter SEC24C is essential for neuronal homeostasis

(2018) Bo Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

(2018) Jeanne E. Savage et al.   NATURE GENETICS

HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein

(2018) Thomas Maurin et al.   NUCLEIC ACIDS RESEARCH

Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome

(2018) Yue Li et al.   Nature Communications

Downregulation of ribosome biogenesis during early forebrain development

(2018) Kevin F Chau et al.   eLife

Ribosomal biogenesis as an emerging target of neurodevelopmental pathologies

(2018) Michal Hetman et al.   JOURNAL OF NEUROCHEMISTRY

Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins

(2018) Ethan J. Greenblatt et al.   SCIENCE

Human Models Are Needed for Studying Human Neurodevelopmental Disorders

(2018) Xinyu Zhao et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Widespread RNA editing dysregulation in brains from autistic individuals

(2018) Stephen S. Tran et al.   NATURE NEUROSCIENCE

CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins

(2017) Eric L. Van Nostrand et al.   METHODS

Autism Spectrum Disorder in Fragile X Syndrome: Cooccurring Conditions and Current Treatment

(2017) Walter E. Kaufmann et al.   PEDIATRICS

Advances and challenges in the detection of transcriptome-wide protein-RNA interactions

(2017) Emily C. Wheeler et al.   Wiley Interdisciplinary Reviews-RNA

Elongator controls cortical interneuron migration by regulating actomyosin dynamics

(2016) Sylvia Tielens et al.   CELL RESEARCH

Network-based approaches for analysis of complex biological systems

(2016) Deborah Chasman et al.   CURRENT OPINION IN BIOTECHNOLOGY

Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics

(2016) Adam E. Handel et al.   HUMAN MOLECULAR GENETICS

irCLIP platform for efficient characterization of protein–RNA interactions

(2016) Brian J Zarnegar et al.   NATURE METHODS

Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

(2016) Eric L Van Nostrand et al.   NATURE METHODS

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons

(2016) Ricardos Tabet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria

(2016) J. U. Guo et al.   SCIENCE

Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation

(2016) Ping Lu et al.   Science China-Life Sciences

Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials

(2016) Elizabeth Berry-Kravis et al.   Science Translational Medicine

Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis

(2016) Olfa Khalfallah et al.   STEM CELLS

Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells

(2016) Meng Li et al.   STEM CELLS

Integrating Transcriptomic and Proteomic Data Using Predictive Regulatory Network Models of Host Response to Pathogens

(2016) Deborah Chasman et al.   PLoS Computational Biology

Delayedin vitrodevelopment of Up states but normal network plasticity in Fragile X circuits

(2015) Helen Motanis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mavoglurant in adolescents with fragile X syndrome: analysis of Clinical Global Impression-Improvement source data from a double-blind therapeutic study followed by an open-label, long-term extension study

(2015) Donald B. Bailey et al.   Journal of Neurodevelopmental Disorders

Dysregulation and restoration of translational homeostasis in fragile X syndrome

(2015) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

Molecular Mechanisms Regulating Impaired Neurogenesis of Fragile X Syndrome Human Embryonic Stem Cells

(2015) Michael Telias et al.   STEM CELLS AND DEVELOPMENT

Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis

(2015) Jean-Marc Taymans et al.   TRENDS IN MOLECULAR MEDICINE

Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells

(2015) Tomer Halevy et al.   Stem Cell Reports

Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity

(2014) Stewart Anderson et al.   CURRENT OPINION IN NEUROBIOLOGY

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

(2014) Mark D M Leiserson et al.   NATURE GENETICS

iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in Initial Neurite Outgrowth

(2014) Matthew E. Doers et al.   STEM CELLS AND DEVELOPMENT

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

(2014) Dae-Sung Kim et al.   Frontiers in Cellular Neuroscience

The emerging roles of ribosome biogenesis in craniofacial development

(2014) Adam P. Ross et al.   Frontiers in Physiology

FMR1 Epigenetic Silencing Commonly Occurs in Undifferentiated Fragile X-Affected Embryonic Stem Cells

(2014) Michal Avitzour et al.   Stem Cell Reports

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

(2013) Asif M. Maroof et al.   Cell Stem Cell

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling

(2013) Shao-shan Carol Huang et al.   PLoS Computational Biology

SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)

(2013) Brett S Abrahams et al.   Molecular Autism

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Species-Dependent Posttranscriptional Regulation of NOS1 by FMRP in the Developing Cerebral Cortex

(2012) Kenneth Y. Kwan et al.   CELL

Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis

(2012) Michael Telias et al.   DEVELOPMENTAL BIOLOGY

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

An experimental investigation of kernels on graphs for collaborative recommendation and semisupervised classification

(2012) François Fouss et al.   NEURAL NETWORKS

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Algorithms for Detecting Significantly Mutated Pathways in Cancer

(2011) Fabio Vandin et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

(2011) Steven D. Sheridan et al.   PLoS One

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

(2010) C. Gross et al.   JOURNAL OF NEUROSCIENCE

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

(2009) X.-J. Li et al.   DEVELOPMENT

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

(2009) Esti Yeger-Lotem et al.   NATURE GENETICS

The State of Synapses in Fragile X Syndrome

(2009) Brad E. Pfeiffer et al.   NEUROSCIENTIST

Walking the Interactome for Prioritization of Candidate Disease Genes

(2008) Sebastian Köhler et al.   AMERICAN JOURNAL OF HUMAN GENETICS