The translation of translational control by FMRP: therapeutic targets for FXS

Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

(2013) Emily K. Osterweil et al.   NEURON

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

(2012) Asha L. Bhakar et al.   Annual Review of Neuroscience

Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model

(2012) Inge Heulens et al.   BEHAVIOURAL BRAIN RESEARCH

Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model

(2012) S. M. Goebel-Goody et al.   GENES BRAIN AND BEHAVIOR

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

(2012) C. A. Hoeffer et al.   GENES BRAIN AND BEHAVIOR

Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome

(2012) Sally M. Till et al.   HUMAN MOLECULAR GENETICS

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(2012) Christina Gross et al.   MOLECULAR MEDICINE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

(2012) Jennifer A Ronesi et al.   NATURE NEUROSCIENCE

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

(2012) Aubin Michalon et al.   NEURON

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen

(2012) C. Henderson et al.   Science Translational Medicine

Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial

(2012) E. M. Berry-Kravis et al.   Science Translational Medicine

Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain Function

(2012) J. C. Darnell et al.   Cold Spring Harbor Perspectives in Biology

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

(2012) Natalie F. Shanks et al.   Cell Reports

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase

(2011) S. S. Siller et al.   Disease Models & Mechanisms

Inhibition of GSK3  improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome

(2011) W. Guo et al.   HUMAN MOLECULAR GENETICS

Abnormal Presynaptic Short-Term Plasticity and Information Processing in a Mouse Model of Fragile X Syndrome

(2011) P.-Y. Deng et al.   JOURNAL OF NEUROSCIENCE

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

Bidirectional Regulation of Dendritic Voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein

(2011) Hye Young Lee et al.   NEURON

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

(2011) D. D. Krueger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Open-label add-on treatment trial of minocycline in fragile X syndrome

(2010) Carlo Paribello et al.   BMC Neurology

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

(2010) C. Gross et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

Fragile X Mental Retardation Protein Is Required for Rapid Experience-Dependent Regulation of the Potassium Channel Kv3.1b

(2010) J. G. Strumbos et al.   JOURNAL OF NEUROSCIENCE

Delayed Stabilization of Dendritic Spines in Fragile X Mice

(2010) A. Cruz-Martin et al.   JOURNAL OF NEUROSCIENCE

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Critical Period Plasticity Is Disrupted in the Barrel Cortex of Fmr1 Knockout Mice

(2010) Emily G. Harlow et al.   NEURON

Early developmental alterations in GABAergic protein expression in fragile X knockout mice

(2010) Daniel C. Adusei et al.   NEUROPHARMACOLOGY

GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism

(2010) Marjelo A. Mines et al.   PLoS One

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

(2010) Feng Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome

(2010) A. Suvrathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HITS-CLIP: panoramic views of protein-RNA regulation in living cells

(2010) Robert B. Darnell   Wiley Interdisciplinary Reviews-RNA

Making synaptic plasticity and memory last: mechanisms of translational regulation

(2009) J. D. Richter et al.   GENES & DEVELOPMENT

Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities

(2009) Janin Schütt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulation of EIF4E: a novel mechanism for autism

(2009) M Neves-Pereira et al.   JOURNAL OF MEDICAL GENETICS

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome

(2009) E Berry-Kravis et al.   JOURNAL OF MEDICAL GENETICS

Altered Hippocampal Synaptic Plasticity in the Fmr1 Gene Family Knockout Mouse Models

(2009) Jing Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

Requirement for Protein Synthesis at Developing Synapses

(2009) J. Sebeo et al.   JOURNAL OF NEUROSCIENCE

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits

(2009) S. B. Christie et al.   JOURNAL OF NEUROSCIENCE

The Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation

(2009) Cheryl L. Gatto et al.   MOLECULAR NEUROBIOLOGY

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Presynaptic translation: stepping out of the postsynaptic shadow

(2009) Michael Akins   Frontiers in Neural Circuits

A Mouse Model of the Human Fragile X Syndrome I304N Mutation

(2009) Julie B. Zang et al.   PLoS Genetics

Minocycline and neurodegenerative diseases

(2008) Hye-Sun Kim et al.   BEHAVIOURAL BRAIN RESEARCH

The Autistic Neuron: Troubled Translation?

(2008) Raymond J. Kelleher et al.   CELL

The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP

(2008) Ilaria Napoli et al.   CELL

Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome

(2008) Jay R. Gibson et al.   JOURNAL OF NEUROPHYSIOLOGY

Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation

(2008) J. A. Ronesi et al.   JOURNAL OF NEUROSCIENCE

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

(2008) Shuang Chang et al.   Nature Chemical Biology

Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory

(2008) François V Bolduc et al.   NATURE NEUROSCIENCE

Features of 80S mammalian ribosome and its subunits

(2008) T. V. Budkevich et al.   NUCLEIC ACIDS RESEARCH

Altered protein synthesis is a trigger for long-term memory formation

(2007) Eric Klann et al.   NEUROBIOLOGY OF LEARNING AND MEMORY