ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste

(2022) Janie F. Shelton et al.   NATURE GENETICS

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

(2022) Jennifer E. Huffman et al.   NATURE GENETICS

Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches

(2022) Verena Zuber et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

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Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies

(2021) Bart G Pijls et al.   BMJ Open

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

(2021) Sirui Zhou et al.   NATURE MEDICINE

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

(2021) Christoph Muus et al.   NATURE MEDICINE

A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

(2021) Christopher N. Foley et al.   Nature Communications

Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity

(2021) João Fadista et al.   EBioMedicine

A neutrophil activation signature predicts critical illness and mortality in COVID-19

(2021) Matthew L. Meizlish et al.   Blood Advances

A molecular single-cell lung atlas of lethal COVID-19

(2021) Johannes C. Melms et al.   NATURE

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

(2021) Toni M. Delorey et al.   NATURE

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

(2021) Liam Gaziano et al.   NATURE MEDICINE

The story behind COVID-19 vaccines

(2021) Anthony S. Fauci   SCIENCE

Untangling introductions and persistence in COVID-19 resurgence in Europe

(2021) Philippe Lemey et al.   NATURE

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

(2021) Delphine Planas et al.   NATURE

Virus-induced senescence is driver and therapeutic target in COVID-19

(2021) Soyoung Lee et al.   NATURE

Mapping the human genetic architecture of COVID-19

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Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

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Vaccine nationalism and the dynamics and control of SARS-CoV-2

(2021) Caroline E. Wagner et al.   SCIENCE

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization

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SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

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A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

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Circulating Cytokines and Coronavirus Disease: A Bi-Directional Mendelian Randomization Study

(2021) Mengyu Li et al.   Frontiers in Genetics

A Multicenter Analysis of the Outcome of Cancer Patients with Neutropenia and COVID-19 Optionally Treated with Granulocyte-Colony Stimulating Factor (G-CSF): A Comparative Analysis

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SARS-CoV-2 infection in the mouse olfactory system

(2021) Qing Ye et al.   Cell Discovery

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

(2021) Mona Khan et al.   CELL

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

(2021) Damien J. Downes et al.   NATURE GENETICS

Mapping the proteo-genomic convergence of human diseases

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A prenylated dsRNA sensor protects against severe COVID-19

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Synergistic insights into human health from aptamer- and antibody-based proteomic profiling

(2021) Maik Pietzner et al.   Nature Communications

Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

(2020) Michael A. Durante et al.   NATURE NEUROSCIENCE

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

(2020) Soeren Lukassen et al.   EMBO JOURNAL

Real-time tracking of self-reported symptoms to predict potential COVID-19

(2020) Cristina Menni et al.   NATURE MEDICINE

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

(2020) Bertrand Bryche et al.   BRAIN BEHAVIOR AND IMMUNITY

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy

(2020) Giacomo Grasselli et al.   JAMA Internal Medicine

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

(2020) David H. Brann et al.   Science Advances

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Effect of Recombinant Human Granulocyte Colony–Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and Lymphopenia

(2020) Lin-ling Cheng et al.   JAMA Internal Medicine

Large-Scale Multi-omic Analysis of COVID-19 Severity

(2020) Katherine A. Overmyer et al.   Cell Systems

Risk factors for severe and critically ill COVID‐19 patients: A review

(2020) Ya‐dong Gao et al.   ALLERGY

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Genetic mechanisms of critical illness in Covid-19

(2020) Erola Pairo-Castineira et al.   NATURE

Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19

(2020) Saskia Trump et al.   NATURE BIOTECHNOLOGY

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

(2020) Jenny Meinhardt et al.   NATURE NEUROSCIENCE

Open Targets Platform: supporting systematic drug–target identification and prioritisation

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SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data

(2020) Matthew D Young et al.   GigaScience

SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain

(2020) Leon Fodoulian et al.   iScience

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

(2019) Nick Shrine et al.   NATURE GENETICS

A new Elf5 Cre ERT 2‐ GFP BAC transgenic mouse model for tracing Elf5 cell lineages in adult tissues

(2019) Snahlata Singh et al.   FEBS LETTERS

Comprehensive Integration of Single-Cell Data

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Improving the diagnostic yield of exome- sequencing by predicting gene–phenotype associations using large-scale gene expression analysis

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Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region

(2019) Hannah Swahn et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

FINEMAP: efficient variable selection using summary data from genome-wide association studies

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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

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Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

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A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Type 2 alveolar cells are stem cells in adult lung

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Dedifferentiation of committed epithelial cells into stem cells in vivo

(2013) Purushothama Rao Tata et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer

(2012) Maria Kalyuga et al.   PLOS BIOLOGY

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data

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Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

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Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

(2010) Jeffrey A. Whitsett et al.   Annual Review of Medicine

Contribution of glycosylated recombinant human granulocyte colony-stimulating factor (lenograstim) use in current cancer treatment: review of clinical data

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The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation

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Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

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